Protein Alignment CngA and CNGB3

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_061971.3
• Gene: CNGB3 / 54714
• HGNCID: 2153
• Length: 809
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 197/679 - (29%)
• Similarity: 323/679 - (47%)
• Gaps: 113/679 - (16%)

  Fly   196 RKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPD------WFLEKFSNTTNTDKIGKGCPAM 254
            :||::  ...|.|.|..:|.:.......|.:..||.:      ||           |: |..|..
Human   148 KKLVE--GDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWF-----------KV-KKMPLT 198

  Fly   255 EDAALSSEIRGSSVLCNRLSVDPTLQS-----HYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAP 314
            |             ...|:.:..::.|     :..||.:|:||..:|..|:..|.||........
Human   199 E-------------YLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNI 250

  Fly   315 AFWYTLDYLCDFIYLLDTL-VHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYI 378
            .:|...|.:||.|||.|.| :.....|:..|.::.|:..||:||..:..:.|||.|::|.|:.|:
Human   251 HYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYL 315

  Fly   379 WWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACM 443
            ::.       :.|   :.|.||:|:....:|:....|:.......:|:.:....:|.::|.|||:
Human   316 FFG-------FNP---MFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACV 370

  Fly   444 YF-AISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADF 507
            |: |.:|| |..:..|||:..|       .:|:..:||:..||.|||..|.|:...|.:|.:.:|
Human   371 YYWASNYE-GIGTTRWVYDGEG-------NEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNF 427

  Fly   508 LAGVLIFATIVGN----IGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWS 568
            .:||.:|::::|.    ||:..:|.|.    |:..||....||....:...::.||..|:.|||.
Human   428 FSGVFVFSSLIGQMRDVIGAATANQNY----FRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWD 488

  Fly   569 QSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICR 633
            ....|||..:|..||..::..:||.|:...:.:|.:|...:..::..::|:||..::.|||::|:
Human   489 SQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCK 553

  Fly   634 KGDVGKEMYIVKRGKLSVV-GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSD 697
            ||::||||||:|.|::.|: |.||..||.||.|||||||:|:|...|   ||||||||.:.|:::
Human   554 KGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFAN 615

  Fly   698 LFCLAKRDLWETLSDYPEARSTLTQRGCQLL------------RKDGLLDEQIFADSQRVHDSIE 750
            |..|.|:.|.|.|..||::...|.::...||            |||..|......::.::..::.
Human   616 LLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLL 680

  Fly   751 GGIEKLELSVENLNMRLARLLAEYTA---------------SQAKIKQRLAKLEMNGGPGTWRLE 800
            ||..|..|:      ||.:|..|..|               ::.|.|:...|.:.|...|.   |
Human   681 GGTGKASLA------RLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGK---E 736

  Fly   801 CEPQSRARSGRLYSLQPKRRPRSRPDATA 829
            .|.:.:.|       :|:.:|..||:.||
Human   737 NEDKDKGR-------EPEEKPLDRPECTA 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	75/252 (30%)
		CAP_ED	604..717	CDD:237999	53/113 (47%)
		CLZ	720..790	CDD:465160	19/96 (20%)
CNGB3	NP_061971.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..121
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..178		5/24 (21%)
		Ion_trans	231..453	CDD:459842	70/239 (29%)
		Ion conduction pathway. /evidence=ECO:0000305|PubMed:34969976	348..447		33/106 (31%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:34969976	407..410		2/2 (100%)
		C-linker. /evidence=ECO:0000305|PubMed:34969976	450..526		23/79 (29%)
		CAP_ED	524..639	CDD:237999	53/117 (45%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000305|PubMed:34969976, ECO:0000305|PubMed:37463923, ECO:0007744|PDB:8EUC	530..646		53/118 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	698..776		15/71 (21%)