Protein Alignment CngA and Kcnh4

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001074663.1
• Gene: Kcnh4 / 380728
• MGIID: 2156184
• Length: 1018
• Species: Mus musculus
• Alignment Length: 668
• Identity: 169/668 - (25%)
• Similarity: 299/668 - (44%)
• Gaps: 119/668 - (17%)

  Fly   204 KRSKPSALRRTLQALR---QRLT----KRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSS 261
            :|...|.||.|.:..|   .|||    :|.:           |:......:.:..|::.:..::|
Mouse   158 RRGTSSRLRSTKRQNRTVLHRLTGHFGRRGQ-----------SSVKANSNLFEPKPSVPEYKVAS 211

  Fly   262 EIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTL--DYLC 324
             :.||..|....|:...:     |..::.||..|..:.|.....|...:.:.....:||  |...
Mouse   212 -VGGSRCLLLHYSIPKAV-----WDGLILLATFYVAVTVPYNVCFAGDDDTPITSRHTLVSDIAV 270

  Fly   325 DFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHTKGW-YLDVLSMLPTDLAYIWWPPETCSS 387
            :.:::||.:::....::.| |.::.....:..||..|  | ::|:::.||.||.|::  ..|.:|
Mouse   271 EMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLAT--WFFVDLIAALPFDLLYVF--NITVTS 331

  Fly   388 LYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAIL-----VLIHWNACMYFAI 447
            |.    .:::..||||:.||.:..:|....:.         |||.:|     :|.||.||:::.|
Mouse   332 LV----HLLKTVRLLRLLRLLQKLERYSQCSA---------VVLTLLMSVFALLAHWMACVWYVI 383

  Fly   448 S-----------YEIGFSSDSWVYNL---------NGTRNNTLQRQ-YIYSFYWSTLTLTTIGET 491
            .           ::||     |::.|         ||:.....:|. ||.:.|::..:||::|..
Mouse   384 GRREMEANDPLLWDIG-----WLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFG 443

  Fly   492 PTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHEL 555
            ....| |.|.:|.:...|.|.|:.|.:.||:.::|..|...|..:.:||..:|.::...|:...|
Mouse   444 NVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPL 508

  Fly   556 EARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKL 620
            :.|::.:|..||:.:..:|...:|...||:|:|:||:.::.:.| |:.:|.....|.|.||.|.:
Mouse   509 KQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHI 572

  Fly   621 KLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGN- 684
            |....:||:|:.|:||..:..|.|..|.|.|:.|:  .|||.||.|.:.| ..:.|: |...|:
Mouse   573 KTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDN--MVLAILGKGDLIG-ADIPEL-GQEPGSG 633

  Fly   685 -------RRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADS 742
                   :.:|:|::|.|..|..|:.|.|.|.|..|||..:..         :.||..:..|
Mouse   634 AGPSCVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYAAAF---------RAGLPRDLTF--- 686

  Fly   743 QRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRA 807
                 ::..|.|...|...:.:.||::..:: |...:..|...:..|..||       .||.:.:
Mouse   687 -----NLRQGSENNGLGRFSRSPRLSQARSD-TLGSSSDKTLPSITETEGG-------TEPGAGS 738

  Fly   808 RSGR---LYSLQPKRRPR 822
            :..|   |.:|.| .|||
Mouse   739 KPRRPHLLPNLSP-ARPR 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	67/277 (24%)
		CAP_ED	604..717	CDD:237999	42/120 (35%)
		CLZ	720..790	CDD:465160	10/69 (14%)
Kcnh4	NP_001074663.1	PRK13557	41..>134	CDD:237425
		PLN03192	177..>620	CDD:215625	124/484 (26%)
		cNMP_binding	578..667	CDD:459637	31/92 (34%)
		PHA03247	<712..1003	CDD:223021	14/53 (26%)