Protein Alignment CngA and CngB

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_611607.2
• Gene: CngB / 37479
• FlyBaseID: FBgn0266346
• Length: 1040
• Species: Drosophila melanogaster
• Alignment Length: 788
• Identity: 235/788 - (29%)
• Similarity: 372/788 - (47%)
• Gaps: 153/788 - (19%)

  Fly   136 EQDEDEE-------EDDDDVDEDDDDEFGASVC-EDNPEEAIARADHDTQQKQHYQPNASDSSYV 192
            |::|:|:       |...|||||:.|   ..:| .::||    ..:.|..::....|:.::|..|
  Fly   279 EEEEEEKSSPLHQVESQPDVDEDEQD---VQICYNESPE----LQNEDRNERTQRTPSINESEIV 336

  Fly   193 ENGRKLIQEPS-------KRSKPSA-----------LRRTLQALRQRLTKR-------------- 225
                 .:.||.       ...|||:           ||..::.|.:|.|.|
  Fly   337 -----AVDEPDTEMNSDVDHRKPSSAGSLDSQGQQFLRDQVRHLVRRFTARANKVKSRIELPPTP 396

  Fly   226 ------NRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRG---------SSV-LCNRL- 273
                  :.|.||.   .|..:.:...|: :..||.:     |..||         |:| ||:.|
  Fly   397 SSSSTVSSPSPPP---TKSLHPSPQHKV-RLVPAGQ-----SPHRGRLFEADTPRSNVWLCSSLC 452

  Fly   274 -------SVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLD 331
                   ::||..:.:..||.:|||:.|||...:..||.|....|.....|...|:..|.|||||
  Fly   453 GANNDERTLDPQGKIYISWLCVVSLSFLYNAWVIPLRASFPFQTKENTNIWLACDFCADIIYLLD 517

  Fly   332 TLVHMHE-GFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAY-------IWWPPETCSSL 388
            .:...|. .:|.:|..|::....|::|.....:.||:|::||.:|.|       :|
  Fly   518 VVFFKHRVMYLFEGFWVKNKNLTRKNYMRKLQFKLDLLALLPLELLYFKLGTQAVW--------- 573

  Fly   389 YLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGF 453
                   :|..|..:|...||.|...:.....|:..|:.|.:..:|.:||..|.:|:|.|...|.
  Fly   574 -------LRFPRFFKIQSFWEVFRLLDRVISSPHFVRVAKTLTYMLYMIHITAALYYAYSDYQGL 631

  Fly   454 SSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIV 518
            ..:.||::..|       ..|:..|.::|.|.|:||:.|.||...||:|:...:|.||.:||.::
  Fly   632 GQNRWVFSGKG-------HPYVRCFAFATKTATSIGKNPKPERQGEYVFMTVAWLMGVFVFALLI 689

  Fly   519 GNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALP 583
            |.|..:||.....:.|::...|...:||....:..|:::||..||.:||.|...|||..:|.|||
  Fly   690 GQIRDIISTATRNKHEYRQLEDETLEYMRRLNLSQEVQSRVKMWFQFTWEQQRTLDESNILDALP 754

  Fly   584 DKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGK 648
            ..||.:|||.||:.||.:|::|.|.|..||..|||||:...|.|||::||||:||:||||||.|:
  Fly   755 INLKTDIAISVHIQTLSKVQLFADCEEALLRDLVLKLRAVTFLPGDFVCRKGEVGREMYIVKLGQ 819

  Fly   649 LSVV-GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSD 712
            :.|: |.....|||||..||||||:|:|.|.|   .:||||:|||.|||:||.|:|.||.|.::.
  Fly   820 VQVMGGPSSDVVLATLTEGSVFGEISLLGING---ADRRTADVRSKGYSNLFVLSKSDLNEVIAY 881

  Fly   713 YPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGI------------EKLELSVENLNM 765
            ||.|::.|.:|..||:||:...:.:  .:.:|...:::..:            :.|:..::.|..
  Fly   882 YPTAQAILKKRARQLMRKNAARERE--EERERARSALQADVVIGNPKTPETAPKLLQTVIQALPF 944

  Fly   766 RLARLLAEYTASQAKIKQRLA---------KLEMNGGPGTWRLECEPQSRARSGR-----LYSLQ 816
            ....::.....|:...::|.:         |:|:.|.     .|.:.|...::||     |.|:|
  Fly   945 ESPAVVLITRGSKRMRRKRQSVQMETIVEPKMEVTGA-----AETQDQKGLKTGRCSPDLLSSIQ 1004

  Fly   817 PKRRPRSR 824
            .:.:.:.:
  Fly  1005 QELKSKHK 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	76/254 (30%)
		CAP_ED	604..717	CDD:237999	63/113 (56%)
		CLZ	720..790	CDD:465160	12/90 (13%)
CngB	NP_611607.2	PLN03192	411..>891	CDD:215625	184/511 (36%)
		CAP_ED	775..889	CDD:237999	64/116 (55%)