Protein Alignment CngA and Kcnh5

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_766393.2
• Gene: Kcnh5 / 238271
• MGIID: 3584508
• Length: 988
• Species: Mus musculus
• Alignment Length: 724
• Identity: 182/724 - (25%)
• Similarity: 293/724 - (40%)
• Gaps: 167/724 - (23%)

  Fly   199 IQEPSKR--SKPSALRRTL---QALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAA 258
            |::.|.:  :|.:.|.|.|   :::.|:||..|:                |:.:.|.....|...
Mouse   138 IEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNK----------------TETVHKHSRLAEVLQ 186

  Fly   259 LSSEIRGSSVLCNRLSVDPTLQSH-----------YRWLAIV-----SLAVLYNIIFVVGRAVFW 307
            |     ||.:|.......|....|           :.|:.::     ::.|.||:.|.
Mouse   187 L-----GSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK------- 239

  Fly   308 EINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHTKGWY-LDVLSM 370
              .|.....|..||.:.|.|:|:|.:::.|..|:.. |.::.|...:|.:|..|  |: :|:||.
Mouse   240 --TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKT--WFVIDLLSC 300

  Fly   371 LPTDLAYIWW-PPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAIL 434
            ||.|:...:. ..|..|||:....|:    ||||:.|:....|         :.......||.:|
Mouse   301 LPYDIINAFENVDEGISSLFSSLKVV----RLLRLGRVARKLD---------HYLEYGAAVLVLL 352

  Fly   435 VLI-----HWNACMYFAI-SYEI------GFSSDSWVYNLN---GT--RNNT----------LQR 472
            |.:     ||.||::::| .||:      ....|||:|.|.   ||  |.||          ...
Mouse   353 VCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDS 417

  Fly   473 QYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQ 536
            .|:.|.|::..:||||| ....|..|||.:|.||..:.|.|::|||.||:.::...|......:.
Mouse   418 LYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYH 482

  Fly   537 NRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQ 601
            ..::.|:.::...:|...|..||:.:...|||.|..:|.|:||:..|..::|:|.:.::.....:
Mouse   483 EMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNE 547

  Fly   602 VRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAG 666
            ...|.....|.|.||.::.:....:|||.|...|:....:..|..|.|.|:.|:  .|:|.||.|
Mouse   548 HPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDE--EVVAILGKG 610

  Fly   667 SVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPE-ARS-----TLTQRGC 725
            .|||::...|    .|.....||||:|.|.||..:.:..|.:.|..|.. |.|     |||   |
Mouse   611 DVFGDIFWKE----TTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLT---C 668

  Fly   726 QL-------------------LRKDGLLDEQIFAD--------------SQRVHDSIEGGIEKLE 757
            .|                   ||:...:...|..|              ..|:..|.:...|:.:
Mouse   669 NLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRIQGSAQSDPERSQ 733

  Fly   758 LSVENLNMR------------------LARLLAEYTASQAKIKQR---LAKLEMNGGPGTWRLEC 801
            |.||:..::                  :...|| |..:...:||.   ..:|:.|||.....|:.
Mouse   734 LQVESRPLQNGASITGTSVVTVSQITPIQTSLA-YVKTSESLKQNNRDAMELKPNGGAEPKCLKV 797

  Fly   802 EPQSRARSG 810
            ....|.::|
Mouse   798 NSPIRMKNG 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	82/293 (28%)
		CAP_ED	604..717	CDD:237999	36/113 (32%)
		CLZ	720..790	CDD:465160	20/123 (16%)
Kcnh5	NP_766393.2	PAS_9	39..132	CDD:463873
		PLN03192	217..>616	CDD:215625	121/424 (29%)
		Selectivity filter. /evidence=ECO:0000250	432..437		3/4 (75%)
		Crp	551..758	CDD:440428	53/215 (25%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		0/10 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..741		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	838..893
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948