Protein Alignment CngA and Kcnh8

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_036016335.1
• Gene: Kcnh8 / 211468
• MGIID: 2445160
• Length: 1103
• Species: Mus musculus
• Alignment Length: 693
• Identity: 170/693 - (24%)
• Similarity: 297/693 - (42%)
• Gaps: 152/693 - (21%)

  Fly   186 ASDSSYVENGRKLIQEPSKRSK-----------PSALRRT---LQALRQRLTKRNRPKPPDWFLE 236
            ||.....:...|:..|..|..:           .||.||:   |..:...|.:|.:.|      .
Mouse   128 ASFKDITDTKVKITSEDKKEDRTKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNK------L 186

  Fly   237 KFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAI-----VSLAVLYN 296
            |.:|....||     ||..:..:|...:...:|.:    ..|.::.:.||.:     |::.|.||
Mouse   187 KINNNVFVDK-----PAFPEYKVSDAKKSKFILLH----FSTFKAGWDWLILLATFYVAVTVPYN 242

  Fly   297 IIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLL-DTLVHMHEGFLDQ-GLLVRDAFRLRRHYFH 359
            :.|:...      :.|........|...:.:::: |.:::....::.: |.::.:|..:..||..
Mouse   243 VCFIGNE------DLSTTRSTTVSDIAVEILFIIADIILNFRTTYVSKSGQVIFEARSICIHYVT 301

  Fly   360 TKGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDR-TETATGYPN 422
            |  |: :|:::.||.||.|.:  ..|..||.    .:::..||||:.||.:..|| ::.:|
Mouse   302 T--WFIIDLIAALPFDLLYAF--NVTVVSLV----HLLKTVRLLRLLRLLQKLDRYSQHST---- 354

  Fly   423 AFRICKVVLAIL-----VLIHWNACMYFAI-----------SYEIGFSSDSWVYNLNGTR----- 466
                  :||.:|     :|.||.||:::.|           .:|:|     |::.| |.|
Mouse   355 ------IVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVG-----WLHEL-GKRLESPY 407

  Fly   467 --NNTL-----QRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGS 523
              ||||     :..||.:.|::..:||::|......| |.|.:|.:...|.|.|:.|.:.||:.:
Mouse   408 YGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTA 472

  Fly   524 MISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKA 588
            :|..|......:..|...:|.::....:..:|:.|::.:|..|||.:..:|...:|...||:|::
Mouse   473 IIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRS 537

  Fly   589 EIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVG 653
            :|.:.::.:.| |:.:|.....|.|.:|.|.:|....:||:|:.|:||..:.:|.|..|.:.|:.
Mouse   538 DITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK 601

  Fly   654 DDGITVLATLGAGSVFG-EVSVLE--IAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPE 715
            |.  .|||.||.|.:.| .:|:.:  |..|       |:|::|.|.||.|:..:.|:|.|..|||
Mouse   602 DS--MVLAILGKGDLIGANLSIKDQVIKTN-------ADVKALTYCDLQCIILKGLFEVLGLYPE 657

  Fly   716 ARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAK 780
            ......:                  |.|  ||......|..|..|      ::||..:.|.|||:
Mouse   658 YAHKFVE------------------DIQ--HDLTYNLREGHESDV------ISRLSNKSTVSQAE 696

  Fly   781 ------IKQRLAKLEMNGGPGTWRLECEPQSRARSGRLYSLQP 817
                  |.:||..:          :|.|.:.........||.|
Mouse   697 PKGNGSINKRLPSI----------VEDEEEEEVEEEETTSLSP 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	70/284 (25%)
		CAP_ED	604..717	CDD:237999	40/115 (35%)
		CLZ	720..790	CDD:465160	16/75 (21%)
Kcnh8	XP_036016335.1	PAS_9	40..135	CDD:463873	2/6 (33%)
		PLN03192	175..>616	CDD:215625	122/488 (25%)
		PRK11753	579..>657	CDD:236969	29/86 (34%)