Protein Alignment CngA and tax-2

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_492427.3
• Gene: tax-2 / 172723
• WormBaseID: WBGene00006525
• Length: 800
• Species: Caenorhabditis elegans
• Alignment Length: 802
• Identity: 234/802 - (29%)
• Similarity: 364/802 - (45%)
• Gaps: 177/802 - (22%)

  Fly    74 PLEEISGGLFAPFAPTATITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQD 138
            |..|.|..|..|    |..:.|.:|::.|         |.||..           |.|....:.|
 Worm    43 PRSEDSFDLLDP----ANASKEPSASTRP---------LPYPPT-----------RPPEVVIQID 83

  Fly   139 EDEEEDDDDVDEDDDDEF-------------------GASVCEDNPEEAIA----RADHDTQQKQ 180
            |.|......:||.||.|.                   .:|:.||:....|:    ...|...::.
 Worm    84 EVESPILGLIDETDDHELDGRLDPASSFDANSLSATRASSIIEDDVRSQISFIMRERLHSIAKEV 148

  Fly   181 HYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTD 245
            |.:.:|            ::|...|..|    ....::...:.|:|..:|....|....|.:.:.
 Worm   149 HRRTSA------------VREDLIRETP----EDTVSMASNVPKQNEHRPSLMSLIGLQNRSESP 197

  Fly   246 KIG--KGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVF-- 306
            .:.  |.|       ....::|        :..|..:.:..||::|:|..|:|...:..|:.:
 Worm   198 TVDTVKNC-------FGFSLKG--------TFHPYGRFYMTWLSLVTLCFLFNAFCIPLRSSYPY 247

  Fly   307 -----WEINKSAPAFWYTLDYLCDFIYLLD-TLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYL 365
                 |       .:|:.:||.||.:|::| .|:.....|...|:.|:.....:|||..|:.:.|
 Worm   248 QTADNW-------MYWFIVDYSCDLVYVIDMLLIKPRLRFTRGGIQVKIYKDTQRHYLMTRTFKL 305

  Fly   366 DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVV 430
            |:||:|||||.|.::..       :|   |.|:||:|:||..|..||..:.:...|.|.||.:.:
 Worm   306 DILSILPTDLMYFFFGK-------MP---IWRINRVLKINSFWLLFDMLDNSFANPYAIRIARTL 360

  Fly   431 LAILVLIHWNACMYFAISYEIGFSS-----------DSWVYNLNGTRNNTLQRQYIYSFYWSTLT 484
            ..::.:||.|:|:|:.:|....|..           :.||||..|       ..||..||::...
 Worm   361 SYMIYIIHCNSCVYYKLSALQAFGQIAYLENGKWYLNKWVYNNQG-------NAYIRCFYFTAAV 418

  Fly   485 LTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAF- 548
            .|:.|..|.|.|.:||:::...::.||.:||.::|.|..::||.|..|.|||.:||     :|.
 Worm   419 ATSTGNNPAPTNVIEYIYMTCSWMMGVFVFALLLGQIRDIVSNANRNREEFQRKMD-----LALG 478

  Fly   549 --RRVGHELEA--RVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTE 609
              :::|.::|.  ||..||.|||.|...|||::::..||.||:.::|:.||..||.:|::|.|.:
 Worm   479 ECKKLGLKMETTNRVRDWFIYTWQQQKTLDEKKLIEKLPLKLQTDLALSVHYTTLSKVQLFQDCD 543

  Fly   610 PGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV-GDDGITVLATLGAGSVFGEVS 673
            ..||..|||||:..:|.|||.||.||||||||||:.:|.|.|| ||....:.|.|..|:||||:|
 Worm   544 RALLRDLVLKLRPVIFLPGDMICLKGDVGKEMYIINQGILQVVGGDHNEKIFAELAQGAVFGEIS 608

  Fly   674 VLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQI 738
            :|.|.||   |||||::|:.||..||.|||.||.:.:..||:|::.|.::...:|:.|...||:
 Worm   609 LLAIGGN---NRRTASIRAKGYCTLFVLAKEDLNDVIRYYPQAQTILRRKAAAMLKNDKKSDEK- 669

  Fly   739 FADSQRVHDSIEGGIEKLELSVE-----NLNMR----LARLLAEYTASQAKIKQRLAKLEMNGGP 794
                          .||::...|     .:|.|    |..|:|..|             |||...
 Worm   670 --------------TEKIKAQAELEDRCKINPRQVPKLITLIANMT-------------EMNENK 707

  Fly   795 GTWRLEC---EPQSRARSGRLY 813
            |...|:.   |...::|...:|
 Worm   708 GVQELKKVIEEETEKSRRQSIY 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	79/265 (30%)
		CAP_ED	604..717	CDD:237999	60/113 (53%)
		CLZ	720..790	CDD:465160	14/78 (18%)
tax-2	NP_492427.3	Ion_trans	221..467	CDD:459842	80/269 (30%)
		CAP_ED	538..652	CDD:237999	61/116 (53%)