Protein Alignment CngA and Kcnh3

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_006520546.1
• Gene: Kcnh3 / 16512
• MGIID: 1341723
• Length: 1101
• Species: Mus musculus
• Alignment Length: 725
• Identity: 181/725 - (24%)
• Similarity: 289/725 - (39%)
• Gaps: 181/725 - (24%)

  Fly   191 YVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGC---- 251
            |...|.|......:||     |..|..|...|.|:.:.|               .|:.||.
Mouse   161 YGRAGSKGFNANRRRS-----RAVLYHLSGHLQKQPKGK---------------HKLNKGVFGEK 205

  Fly   252 PAMEDAALSSEIRGSSVL---CNRLSVDPTLQSHYRWLAIVSLAVLYNIIFV-----VGRAVFWE 308
            |.:.:..::: ||.|..:   |..|..        .|...:.||.||..:.|     |..|....
Mouse   206 PNLPEYKVAA-IRKSPFILLHCGALRA--------TWDGFILLATLYVAVTVPYSVCVSTAREPS 261

  Fly   309 INKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFHTKGWY-LDVLSML 371
            ..:..|:   ..|...:.:::||.:::....|:.: |.:|.....:..||..|  |: |||::.|
Mouse   262 AARGPPS---VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTT--WFLLDVIAAL 321

  Fly   372 PTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAIL-- 434
            |.||.:.:     ..::|:... :::..||||:.||....||..         :...|||.:|
Mouse   322 PFDLLHAF-----KVNVYVGAH-LLKTVRLLRLLRLLPRLDRYS---------QYSAVVLTLLMA 371

  Fly   435 ---VLIHWNACMYFAISYEIGFSSDS------WVYNL---------------------------- 462
               :|.||.||::|.|..:...||:|      |:..|
Mouse   372 VFALLAHWVACVWFYIGQQEIESSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCS 436

  Fly   463 ----------------NGT-----RNNTLQRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVA 505
                            |||     ...:|:..||.|.|::..:||::|......| |.|.:|.:.
Mouse   437 SSSSSSGSGGGRGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSIC 501

  Fly   506 DFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQS 570
            ..|.|.|:.|.:.||:.::|..|...|..:.:|...::.|:...|:...|:.|::.:|..||:.:
Mouse   502 TMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVN 566

  Fly   571 GALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKG 635
            ..:|...:|.:|||:|:|:||:.:|.:.| |:.:|.....|.|.||.|.|:....:||:|:..:|
Mouse   567 NGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQG 630

  Fly   636 DVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFC 700
            |..:.:|.|..|.:.|:  .|.||||.||.|.:.|    .|:.......:..|:|:.|.|..|.|
Mouse   631 DALQALYFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPQREQVVKANADVKGLTYCVLQC 689

  Fly   701 LAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNM 765
            |....|.|:|:.|||                       ||  .|....:.|     |||   .|:
Mouse   690 LQLAGLHESLALYPE-----------------------FA--PRFSRGLRG-----ELS---YNL 721

  Fly   766 RLARLLAEY-TASQAKIKQRLAKLEMNGGPGTWRLECEPQSRARSGRLYSLQPKRRPRS---RPD 826
            ....:.||. |:|.:.....::.||            |.::....|...|..|...|.|   .|.
Mouse   722 GAGGVSAEVDTSSLSGDNTLMSTLE------------EKETDGEQGHTVSPAPADEPSSPLLSPG 774

  Fly   827 ATAKSSDAAK 836
            .|: ||.|||
Mouse   775 CTS-SSSAAK 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	73/314 (23%)
		CAP_ED	604..717	CDD:237999	39/112 (35%)
		CLZ	720..790	CDD:465160	13/70 (19%)
Kcnh3	XP_006520546.1	PAS_9	40..135	CDD:463873
		PLN03192	233..>668	CDD:215625	121/461 (26%)
		cyc_nuc_ocin	<623..718	CDD:274839	36/130 (28%)