DRSC/TRiP Functional Genomics Resources

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Protein Alignment CngA and Kcnh1

DIOPT Version :10

Sequence 1:NP_001188960.1 Gene:CngA / 36806 FlyBaseID:FBgn0261612 Length:840 Species:Drosophila melanogaster
Sequence 2:NP_034730.1 Gene:Kcnh1 / 16510 MGIID:1341721 Length:989 Species:Mus musculus


Alignment Length:842 Identity:197/842 - (23%)
Similarity:315/842 - (37%) Gaps:262/842 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 TLQALRQR------------LTKRNRPKPPDWFLEKFSNTTN-TDKI------------------ 247
            |::.:||.            :.|:||  .|.||..|.:...| .||:                  
Mouse    79 TVEKVRQTFENYEMNSFEILMYKKNR--TPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIE 141

  Fly   248 -----GKGCPAMEDAALSS-------------------------EI--RGSSVLCNRLSVDPTLQ 280
                 |.|..|....||:|                         |:  .||.:|.......|...
Mouse   142 DDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTP 206

  Fly   281 SH-----------YRWLAIV-----SLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYL 329
            .|           :.|:.::     ::.|.||:.|...:      |..|   |..:|.:.|.|:|
Mouse   207 PHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQ------NNVA---WLVVDSIVDVIFL 262

  Fly   330 LDTLVHMHEGFL-DQGLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDL-----------AYIWWP 381
            :|.:::.|..|: ..|.::.|...:|.:|..|  |: :|:||.||.|:           |::..|
Mouse   263 VDIVLNFHTTFVGPAGEVISDPKLIRMNYLKT--WFVIDLLSCLPYDVINAFENVDEVSAFMGDP 325

  Fly   382 PETCSSLYLPCPV----------------IVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVV 430
            .:...:..:|.|:                :|||.||.|:.|..:.:.....|            |
Mouse   326 GKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAA------------V 378

  Fly   431 LAILVLI-----HWNACMYFAI-SYEIGFSSD-------SWVYNL-------------------N 463
            |.:||.:     ||.||::::| .||| |..|       ||:|.|                   .
Mouse   379 LVLLVCVFGLAAHWMACIWYSIGDYEI-FDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEG 442

  Fly   464 GTRNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISN 527
            |...|::   ||.|.|::..:||::| ....|..|:|.:|.||..:.|.|::|||.||:.::...
Mouse   443 GPSKNSV---YISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQ 504

  Fly   528 MNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAI 592
            |......:...::.|:.::...:|...|..||:.:...|||.|..:|.|:||...|..::|:|.:
Mouse   505 MYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICV 569

  Fly   593 QVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGI 657
            .::....|:...|.....|.|.||.::.:....:|||.|...|:....:..|..|.|.|:.||  
Mouse   570 HLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDD-- 632

  Fly   658 TVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQ 722
            .|:|.||.|.|||:|...|    .|..:..||||:|.|.||..: |||..:.:.::..|.|....
Mouse   633 EVVAILGKGDVFGDVFWKE----ATLAQSCANVRALTYCDLHVI-KRDALQKVLEFYTAFSHSFS 692

  Fly   723 RGCQL---LRK--------DGLLDE------------------------QIFADSQRVHDSIE-G 751
            |...|   |||        |...:|                        |.|...:....:.| |
Mouse   693 RNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERG 757

  Fly   752 GIEKLELSVENLNMRLARLLAEYT-ASQAKIKQRL------------------------AKLEMN 791
            |.:..:|.||..|     .|.::| |:.:.:|..:                        |||...
Mouse   758 GRDLDDLDVEKGN-----ALTDHTSANHSLVKASVVTVRESPATPVSFQAATTSTMSDHAKLHAP 817

  Fly   792 GGP--GTWRLECEPQSRARSGRLYSLQPK-----------------RRPRSRPDATAKSSDA 834
            |..  |...:.|:|..|....|......|                 .|.::..:||.|.:|:
Mouse   818 GSECLGPKAVSCDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKAPGEATLKKTDS 879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CngANP_001188960.1 Ion_trans 282..529 CDD:459842 80/324 (25%)
CAP_ED 604..717 CDD:237999 38/112 (34%)
CLZ 720..790 CDD:465160 23/130 (18%)
Kcnh1NP_034730.1 PAS_9 41..135 CDD:463873 13/57 (23%)
Required for phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250|UniProtKB:O95259 151..162 4/10 (40%)
PLN03192 220..>647 CDD:215625 121/455 (27%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q63472 463..468 1/4 (25%)
PRK11753 608..>712 CDD:236969 37/110 (34%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:27618660 673..770 20/96 (21%)
Interaction with cyclic nucleotide-binding pocket. /evidence=ECO:0000269|PubMed:22732247 699..701 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 857..905 5/23 (22%)
CAD (involved in subunit assembly). /evidence=ECO:0000250|UniProtKB:Q63472 924..964
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 961..989
Blue background indicates that the domain is not in the aligned region.

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