Protein Alignment CngA and Kcnh6

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_006247617.1
• Gene: Kcnh6 / 116745
• RGDID: 620304
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 695
• Identity: 174/695 - (25%)
• Similarity: 291/695 - (41%)
• Gaps: 139/695 - (20%)

  Fly   231 PDWFLEKFSNTTN--TDKIGKGCPAMEDAALSS-EIRGSSVLCNRLSVDPTLQSHYR-----WLA 287
            |...:|:..|.|.  |..:..|...:.:..|.: .|...::|            ||.     |..
  Rat   209 PHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTIL------------HYSPFKAVWDW 261

  Fly   288 IVSLAVLYNIIFVVGRAVFW---EINKSAPAFWYT------LDYLCDFIYLLDTLVHMHEGFLD- 342
            ::.|.|:|..:|....|.|.   :.........||      :|.:.|.::::|.:::....:::
  Rat   262 LILLLVIYTAVFTPYSAAFLLSDQDESQRGTCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNT 326

  Fly   343 QGLLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINR 406
            ...:|....|:..|||  |||:| |:::.:|.||.......:..::|.    .:::..||||:.|
  Rat   327 NDEVVSHPRRIAVHYF--KGWFLIDMVAAIPFDLLIFRTGSDETTTLI----GLLKTARLLRLVR 385

  Fly   407 LWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISY--------EIGFSSDSWVYNL- 462
            :....||............:|...|    :.||.||:::||..        :||     |:.:|
  Rat   386 VARKLDRYSEYGAAVLFLLMCTFAL----IAHWLACIWYAIGNVERPYLEPKIG-----WLDSLG 441

  Fly   463 -------NGT---RNNTLQRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFAT 516
                   ||:   ...::|.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:
  Rat   442 AQLGKQYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYAS 506

  Fly   517 IVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAA 581
            |.||:.::|..:......:..:|..||:::.|.::.:.|..|:..:|.:.||.:..:|...||..
  Rat   507 IFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 571

  Fly   582 LPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKR 646
            .|:.|:|:|.:.:|...|:....|.....|.|.||.:|.|.....|||.:...|||...:|.:.|
  Rat   572 FPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISR 636

  Fly   647 GKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLS 711
            |.:.::.||  .|:|.||...:|||.:.|..   |.| :.:|:||:|.|.||..:.:.||.|.|.
  Rat   637 GSIEILRDD--VVVAILGKNDIFGEPASLHA---RPG-KSSADVRALTYCDLHKIHRADLLEVLD 695

  Fly   712 DYPEARSTLTQR---------GCQL---------------LRKDGLL-----------DEQIFAD 741
            .||....|...:         .|.|               .|:||.|           |.|.|.
  Rat   696 MYPAFADTFWNKLEVTFNLRDSCPLHVILLMAIILMNKPTTREDGGLQSTPRQAPGHQDPQGFF- 759

  Fly   742 SQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRL--------AKLE-----MNGG 793
               ::||..|...  .||:.:.:.....||.:...|....:|.|        .|||     ||
  Rat   760 ---LNDSQSGAAP--SLSISDTSALWPELLQQMPPSPPNPRQDLDCWPRELGFKLEQLQAQMN-- 817

  Fly   794 PGTWRLECEPQSRARSGRLYSLQPKRRPRSRPD---ATAKSSDAA 835
                |||    ||..|.....||..:.|:.||.   ..:.|||.|
  Rat   818 ----RLE----SRVSSDLSRILQLLQHPQGRPSYILGASASSDLA 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	66/282 (23%)
		CAP_ED	604..717	CDD:237999	41/112 (37%)
		CLZ	720..790	CDD:465160	22/117 (19%)
Kcnh6	XP_006247617.1	PAS_9	38..132	CDD:463873
		PLN03192	259..>698	CDD:215625	121/459 (26%)