Protein Alignment CngA and hcn1

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_031750156.1
• Gene: hcn1 / 100490760
• XenbaseID: XB-GENE-950265
• Length: 839
• Species: Xenopus tropicalis
• Alignment Length: 691
• Identity: 156/691 - (22%)
• Similarity: 306/691 - (44%)
• Gaps: 104/691 - (15%)

  Fly   141 EEEDDDDVDEDDDDEFGASVCEDNPEEAIARADHDTQQKQH-----YQPNASDSSYVENGRKLIQ 200
            |.:.:...:...||  |.:|.:...|:::..:  .:..|:|     ::.:|:|...|.     .:
 Frog     2 ESKFNSSTNSSRDD--GNNVLQGKAEKSLTAS--TSSVKEHGNSVCFKTDAADDPVVG-----FE 57

  Fly   201 EPSKRSKPSA-LRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIR 264
            :....|:|.. ::|...:|.|       |....:.|..|.:....:|            ....::
 Frog    58 DAEGPSRPHGFMQRQFGSLMQ-------PGVNKFSLRMFGSQKAVEK------------EQERVK 103

  Fly   265 GSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYL 329
            .:.|..    :.|.....:.|..|:.:.::.|::.:.....|:....:.|  |...:...|.::|
 Frog   104 TAGVWI----IHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTP--WIIFNVASDTVFL 162

  Fly   330 LDTLVHMHEGFL--DQGLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIWWPPETCSSLYLP 391
            .|..::...|.:  |...::.|...::.:|.  |.|: :|.:|.:|.|..::.......|.:|..
 Frog   163 FDLFMNFRTGIVIEDNSEIILDPKVIKMNYL--KSWFVVDFISSIPVDYIFLIVEKGMDSEVYKT 225

  Fly   392 CPV--------IVRLNRLLRINRL------WE-----WFDRTETATGYPNAFRICKVVLAILVLI 437
            ...        |:.|.||||::||      ||     .:|......      ||..::..:|:|.
 Frog   226 ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV------RIFNLIGMMLLLC 284

  Fly   438 HWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG---ETPTPENDVE 499
            ||:.|:.|.:.....|..|.|| :||...|::..:||.|:.:.:...:..||   ..|...:|:
 Frog   285 HWDGCLQFLVPLLQEFPPDCWV-SLNNMVNDSWGKQYSYALFKAMSHMLCIGYGARAPVSMSDL- 347

  Fly   500 YLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFA 564
             ...:...:.|...:|..||:..::|.:::.:|.::|.:...|:|||:|.::..::..::..::.
 Frog   348 -WITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPSDMRQKIHDYYE 411

  Fly   565 YTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVR---IFHDTEPGLLEALVLKLKLQVFS 626
            :.: |....||:.:|..|.|.|:.||   |:.:..|.|.   :|.:.:|..:.|::.|||.:||.
 Frog   412 HRY-QGKIFDEDNILNELNDPLREEI---VNFNCRKLVATMPLFANADPNFVTAMLSKLKFEVFQ 472

  Fly   627 PGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVR 691
            |||||.|:|.|||:||.::.|...|:......:..|  .||.|||:.:|      |..||||:||
 Frog   473 PGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLT--DGSYFGEICLL------TKGRRTASVR 529

  Fly   692 SLGYSDLFCLAKRDLWETLSDYPEAR----STLTQRGCQLLRKDGLLDEQIFAD-SQRVHDSIEG 751
            :..|..|:.|:..:..|.|.:||..|    :....|..::.:|:.:|.::...| :..:.::.|.
 Frog   530 AETYCRLYSLSVENFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILQQRFQKDLNTGIFNNQES 594

  Fly   752 GIEKLELSVE--------NLNMRLARLLAEYTASQAKIKQR 784
            .|.|..|:.:        :::.:....|...|:|..:::.|
 Frog   595 EILKQMLTQDREMVEGHPSVSYQQLPALNSSTSSSLRMRTR 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	59/271 (22%)
		CAP_ED	604..717	CDD:237999	43/112 (38%)
		CLZ	720..790	CDD:465160	12/74 (16%)
hcn1	XP_031750156.1	Ion_trans_N	73..115	CDD:400630	8/64 (13%)
		PLN03192	108..>587	CDD:215625	127/507 (25%)
		CAP_ED	450..558	CDD:237999	44/115 (38%)
		Atrophin-1	604..>816	CDD:460830	4/32 (13%)