Protein Alignment CngA and hcn1

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_068072094.1
• Gene: hcn1 / 100334297
• ZFINID: ZDB-GENE-110520-1
• Length: 925
• Species: Danio rerio
• Alignment Length: 472
• Identity: 129/472 - (27%)
• Similarity: 228/472 - (48%)
• Gaps: 55/472 - (11%)

  Fly   275 VDPTLQSHYRWLAIVSLAVLYNIIFV-VGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHE 338
            :.|.....:.|..|:.:.::.|:|.: ||...|.|...::   |...:...|.|:|:|.:::...
Zfish   112 IHPYSDFRFYWDLIMLIMMMGNLIIIPVGITFFSEQTTTS---WLVFNVASDTIFLVDLVMNFRT 173

  Fly   339 GFLDQ--GLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIWWPPETCSSLYLPCPV------ 394
            |.:::  ..::.|...::.:|.  |.|: :|.||.:|.|..::.......|.:|.....
Zfish   174 GIVNEESSEIILDPKVIKMNYL--KSWFVVDFLSSIPVDYIFLIVEKGFDSEVYKTARALRIVRF 236

  Fly   395 --IVRLNRLLRINRL------WE-----WFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFA 446
              |:.|.||||::||      ||     .:|......      ||..::..:|:|.||:.|:.|.
Zfish   237 TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV------RIFNLIGMMLLLCHWDGCLQFL 295

  Fly   447 ISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG---ETPTPENDVEYLFVVADFL 508
            :.....|..|.|| :|||..|::..:||.|:.:.:...:..||   ..|...:|:  ...:...:
Zfish   296 VPLLQDFPPDCWV-SLNGMVNDSWGKQYSYALFKAMSHMLCIGYGARAPVSMSDL--WITMLSMI 357

  Fly   509 AGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGAL 573
            .|...:|..||:..::|.:::.:|.::|.:...|:|||:|.::..::..::..::.:.: |....
Zfish   358 VGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKIF 421

  Fly   574 DEERVLAALPDKLKAEIAIQVHMDTLKQVR---IFHDTEPGLLEALVLKLKLQVFSPGDYICRKG 635
            ||:.:|..|.|.||.||   |:.:..|.|.   :|.:.:|..:..::.|||.:||.|.|||.|:|
Zfish   422 DEDSILNELNDPLKEEI---VNFNCRKLVATMPLFANADPNFVTGMLSKLKFEVFQPNDYIIREG 483

  Fly   636 DVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFC 700
            .|||:||.::.|..||:......:..|  .||.|||:.:|      |..||||:||:..|..||.
Zfish   484 TVGKKMYFIQHGVASVITKFNKELKLT--DGSYFGEICLL------TKGRRTASVRADTYCRLFS 540

  Fly   701 LAKRDLWETLSDYPEAR 717
            |:.....|.|.:||..|
Zfish   541 LSVDHFNEVLEEYPMMR 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	64/272 (24%)
		CAP_ED	604..717	CDD:237999	43/112 (38%)
		CLZ	720..790	CDD:465160
hcn1	XP_068072094.1	Ion_trans_N	75..117	CDD:400630	1/4 (25%)
		PLN03192	110..>614	CDD:215625	129/472 (27%)
		CAP_ED	452..560	CDD:237999	44/114 (39%)
		PHA03247	<653..906	CDD:223021