DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf3 and meltf

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_009300716.1	Gene:	meltf / 565942	ZFINID:	ZDB-GENE-050309-40	Length:	724	Species:	Danio rerio

Alignment Length:	773	Identity:	173/773 - (22%)
Similarity:	294/773 - (38%)	Gaps:	170/773 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SFLSISMCVAVQPPDDGKLRVCVVESRGVYRKTPKFCPLLEAKSN------IECVIGVDRLDCVR 72
            :|||:.:.:.........:|.||:.    ..:..|...:.:|.|:      ::||:...:.:|.:
Zfish     5 TFLSVLLALTHYVSGQSTIRWCVIS----VAEESKCKAMAQAFSSASVRPALKCVLAASKAECAQ 65

  Fly    73 RI--HKGTAHFGVLTSEDLVAARWASVEILVASELRSHESHFEYEIVAVVDNHANIHTVHDLRGA 135
            ::  .|....|.....:.....:.||.:| .|.|..|......|..||||........:::|:|.
Zfish    66 KLTQKKEVDAFSASAKDIYDIGKLASFKI-AAGESGSDGKGITYYGVAVVKKTNAAININNLKGK 129

  Fly   136 RLCHPGYGLGNHWTEVLANYFEAAMVS-KTCD-PEMTVTEDRIASTAKYFGPSCKAGPWVPDPKQ 198
            :.||.|......|...|....::.|:| ..|: |:         ..|.:|..||     :|..|.
Zfish   130 KSCHTGKNRTAGWNVPLGYLIDSGMMSVMGCNIPQ---------GVADFFNASC-----IPGAKD 180

  Fly   199 DRILKNRYPSLCEMCYEPDS----CDQTDK--HWGRRGALYCLTSGGGNVAWARLDDVRSHFGFS 257
            |.      .|||:.|....:    ||.::|  ::...||..||....|:||:.:...|..:....
Zfish   181 DP------ASLCQQCVGDRTGQFKCDPSNKELYYAYDGAFRCLVEDAGDVAFVKHTTVSENTDGK 239

  Fly   258 GIP-AQSNPS-DFSYLCPDGHLQPLNASQPCVWVAKPWPVVAARRSHAAQV--QRLVTGLNHDEP 318
            |.. ||...| |:..||.||...|:...:.|               |.|:|  :.:|.     .|
Zfish   240 GASWAQELQSKDYQLLCRDGTRSPVTDYEKC---------------HLARVPSRGIVI-----HP 284

  Fly   319 DSWQNALLSLLETYHVFTVPL---------------DNVIAIDDYLDQATAFQSA---------- 358
            |      ::....|::.|..|               :|::    :.|.:|.|..|
Zfish   285 D------ITTSVVYNMLTEGLQKSGFSMFSSADFGGENLL----FSDTSTKFIQAGNENYKEWMG 339

  Fly   359 -----YSFPECNP---PRSIVFCTTSIIQHIKCSWLQEASQVYGVQPNIQCVRTMDEQQCLDNTK 415
                 ....:|:.   |..:.:|..|..:..||:.:..|.:...:.||||||.....:.|:...:
Zfish   340 RYYHILKAMDCSQSDIPSQLQWCVLSHGEQQKCADMAVAFKNKNLIPNIQCVYGASVEDCMKKIQ 404

  Fly   416 FKETDVVLVDQEMRVKAQRDYNLVPLLYE-FAADMHDR-YVTIALVHKDAK-FESFRDLKGARAC 477
            .||.|.:.:|......|.:.|.|:|.:.| :..|.... |..:|::.|..: .:.|.||||.|:|
Zfish   405 NKEADAITLDGGYIYTAGKSYGLIPAVGESYTGDSDGSIYYAVAVLRKSNRDIQRFSDLKGKRSC 469

  Fly   478 LPSFEGAA------HLSVQETIVN-ATGKVQSLHSYFHRDSCL---------WNL-------QSG 519
            ...:...|      .|.:::.|:. .|.:|......|...:|:         .||       .||
Zfish   470 HTGYGRTAGWNIPMGLLIEKGIIRPQTCQVAQAAGEFFESACVPGADQKDFPENLCKQCIGDSSG 534

  Fly   520 R-KCPLH---YQGDEGALRCLSEG-ADVAFLSSDVYKKYVVGNLTSNWLTPGNHKDFRVLCPYGG 579
            : ||...   |.|.:||.|||.|. .||||:......:...||.|..|....:.::|::||....
Zfish   535 QFKCVKGKDLYDGYDGAFRCLVENHGDVAFVKHSTVFQNTDGNNTDPWAVNLDSREFQLLCSQES 599

  Fly   580 IEKRSNFEYCYLHWTTRGHLMTHNSSL---TRRNEIYNSLRDMDQLFGRKYKSETRPFTLYGIFD 641
            ..:.:.|..|.|     ..:.:|...:   |..:.|:..|....:.||....|:      :.:||
Zfish   600 RAEVTQFTKCNL-----ARVPSHAVMIRPDTNHHIIFGLLDKAQRFFGVNSASD------FKMFD 653

  Fly   642 KR----NNVLFRDDTDGLLGLQELHRDNAKRVMEHIYDRYANTQYYRNFDESGAMKSS 695
            .:    ::::|:|.|..|:|:.|          ...|:.:....|   .|...||:.|
Zfish   654 SKAYEGSDLIFKDSTITLIGVGE----------RKTYEEWLGQSY---LDSLIAMECS 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	81/387 (21%)
		PBP2_transferrin	369..681	CDD:270247	83/349 (24%)
		TR_FER	370..656	CDD:214514	79/323 (24%)
meltf	XP_009300716.1	PBP2_transferrin	22..343	CDD:270247	80/375 (21%)
		TR_FER	23..349	CDD:214514	80/380 (21%)
		Periplasmic_Binding_Protein_Type_2	358..689	CDD:304360	84/354 (24%)
		TR_FER	360..689	CDD:214514	84/352 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.880