DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf3 and RGD1310507

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_038937483.1	Gene:	RGD1310507 / 315963	RGDID:	1310507	Length:	715	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	184/790 - (23%)
Similarity:	292/790 - (36%)	Gaps:	187/790 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILVGLFASFLSIS---------MCVAVQPPDDGKLRVCVVESRGVYRKTPKFCPLLEAKSNIEC 61
            |:.||..|...::|         :|:||   .:..:|.|:|..... .|...|      :.|::.
  Rat     8 LLCVGTLAPVNTVSLPGSHIRNRLCLAV---PEKTIRWCIVSDHEA-TKCSSF------RDNMKK 62

  Fly    62 VI--GVDRLDCVRRIHKGTAHFGVLTSEDLVAARWASVEI---LVASELRSHES----------- 110
            |:  |...:.|||:    |:|...:  .|:.|.:..:|.:   |||.....|.|
  Rat    63 VLPAGGPAVACVRK----TSHLECI--RDISANKIDAVTVDGALVAEADLPHHSLKPIMAEYYGS 121

  Fly   111 ----HFEYEIVAVVDNHANIHTVHDLRGARLCHPGYGLGNHWTEVLANYFEAAMVSKTCDPEMTV 171
                ...|.:||||....... ::.|:|.:.||...|....|...|:              .:..
  Rat   122 KDDPQTHYYVVAVVKKGTGFQ-LNQLQGKKSCHASLGWSAGWYVPLS--------------VLLP 171

  Fly   172 TEDRIASTAKYFGPSCKAGPWVP--DPKQDRILKNRYPSLCEMC----YEPDSCDQTDKHWGRRG 230
            :..|..:.|.:|..||     ||  |.|.       :|.||::|    .:..||...:.::|..|
  Rat   172 SGSRETAAATFFSSSC-----VPCADGKM-------FPRLCQLCSGKGTDKCSCSSGEPYFGYWG 224

  Fly   231 ALYCLTSGGGNVAWARLDDVRSHFGFSGIPAQSNPSDFSYLCPDGHLQPLNASQPCVWVAKPWPV 295
            ||.||..|.|:|::.|...|     |..:|.:::...:..||||...:|::..:.|.....|..|
  Rat   225 ALKCLQDGTGDVSFVRHLTV-----FEVMPRKADRDQYELLCPDNTRRPVDEYEQCYLARVPSHV 284

  Fly   296 VAARRSHAAQVQRLVTGLNHDEPDSWQNALLSLLE--------TYHVFTVPLDNVIAIDD----- 347
            |.||.         |.|    :.||.|..|....|        |:.:|..|....:...|
  Rat   285 VVARS---------VDG----KEDSIQELLRVAQEHFGKDKSSTFQLFGSPHGKDLLFTDAACGL 336

  Fly   348 -----------YL--DQATAFQSAYSFPECNPPRSIVFCTTSIIQHIKCS-WLQEASQVYGVQPN 398
                       ||  :..:|.::.....|  ..|.:.:|.....:..||. |    |.|.|  ..
  Rat   337 LRVPPKMDIGLYLGYELLSAIRNLKRGSE--DSRRVKWCAVGQQERAKCDHW----SAVSG--GA 393

  Fly   399 IQCVRTMDEQQCLDNTKFKETDVVLVDQEMRVKAQRDYNLVPLLYEFAADMH------------- 450
            :.|......:.|:......|.|.|.:|......|.. ..|||.|.|.....|
  Rat   394 LACATEETPEDCIAAVMKGEADAVNLDGGFAYIAGH-CGLVPGLGENYLSPHSSERLGSKCVNAA 457

  Fly   451 -DRYVTIALVHKDAKFESFRDLKGARACLPSFEGAAHLSVQETIV-NATGKVQSLHSYF------ 507
             :.|..:|:|.|.....::..|:|.::|..:...:|..:|..::: |.||..: ...:|
  Rat   458 LEGYYVVAVVKKSDVGITWNSLQGKKSCHTAVGTSAGWNVPMSLIYNQTGSCK-FDEFFSGGCAP 521

  Fly   508 --HRDSCLWNLQSGRKCPLH---------YQGDEGALRCLSEGADVAFLSSDVYKKYVVGNLTSN 561
              :.||.|..|.:|...|.|         |.|..||||||.|..||||:......:...|....:
  Rat   522 GANPDSRLCALCAGGNEPAHMCAANNDEGYHGSSGALRCLVEKGDVAFMKHPTVLQNTDGKNPES 586

  Fly   562 WLTPGNHKDFRVLCPYGGIEKRSNFEYCYLHWTTRGHLMTHNSSLTRRNE---IYNSLRDMDQLF 623
            |.....|:||.:||..|..:..:..:.|:|      ..:.:::..:|:::   :...|.:..:||
  Rat   587 WAKGLKHEDFELLCLDGTRKPVTEAQNCHL------DRVPNHAVFSRKDKVDFVQRMLFNQQELF 645

  Fly   624 GRKYKSETRPFTLYGIFDKRNNVLFRDDTDGLLGLQELHRDNAKRVMEHIYDRYANTQYYRNFDE 688
            ||. ..|.|.|.::.  ....::||.|||:.|..||.          :..|..|...||....|.
  Rat   646 GRN-GFEYRMFQMFE--SSHKDLLFSDDTECLSNLQN----------KATYKTYLGPQYLTLMDN 697

  Fly   689 SGAMKSSHNL 698
            .....||..|
  Rat   698 FRQCLSSELL 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	87/386 (23%)
		PBP2_transferrin	369..681	CDD:270247	82/347 (24%)
		TR_FER	370..656	CDD:214514	77/321 (24%)
RGD1310507	XP_038937483.1	PBP2_transferrin_N	39..361	CDD:270336	86/379 (23%)
RGD1310507	XP_038937483.1	PBP2_transferrin_C	367..699	CDD:270335	86/358 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820