DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf3 and Meltf

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_006522295.1	Gene:	Meltf / 30060	MGIID:	1353421	Length:	758	Species:	Mus musculus

Alignment Length:	752	Identity:	164/752 - (21%)
Similarity:	273/752 - (36%)	Gaps:	184/752 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VCVVESRGVYRKTPKFCPLLEA-----------------KSNIECVIGVDRLDCVRRIHKGTAHF 81
            |||:|        .::|.:.:|                 :.::.||.|.....||:.|.:..|..
Mouse    18 VCVME--------VQWCTISDAEQQKCKDMSEAFQGAGIRPSLLCVQGNSADHCVQLIKEQKADA 74

  Fly    82 GVLTSEDLVAARWASVEILVASELRSHESHFEYEIVAVVDNHANIHTVHDLRGARLCHPGYGLGN 146
            ..|....:..|........|..|:...:....|..||||..::|: |::.|:|.:.||.|.....
Mouse    75 ITLDGGAIYEAGKEHGLKPVVGEVYDQDIGTSYYAVAVVRRNSNV-TINTLKGVKSCHTGINRTV 138

  Fly   147 HWTEVLANYFEAAMVS--------------KTCDPEMTVTEDRIASTAKYFGPSCKAGPWVPDPK 197
            .|...:....|:..:|              :.|.|..:... |..:...|||.||..|.......
Mouse   139 GWNVPVGYLVESGHLSVMGCDVLKALCSVPQPCAPSHSPVL-RPTAVGDYFGGSCVPGTGETSHS 202

  Fly   198 QDRILKNRYPSLCEMCYEPDS----CDQT--DKHWGRRGALYCLTSGGGNVAWARLDDVRSHFGF 256
            :         |||.:|....|    ||::  ::::...||..||..|.|:||:.:...|..:...
Mouse   203 E---------SLCRLCRGDSSGHNVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDG 258

  Fly   257 SGIPAQSN---PSDFSYLCPDGHLQPLNASQPCVWVAKPWPVVAARRSHAAQVQRLVTG------ 312
            :.:|:...   ..||..||.||....:...:.|.....|        :||..|:..:.|
Mouse   259 NTLPSWGKSLMSEDFQLLCRDGSRADITEWRRCHLAKVP--------AHAVVVRGDMDGGLIFQL 315

  Fly   313 -------LNHDEPD---------SWQNALL--SLLETYHVFTVPLDNVIAIDDY---LDQATAFQ 356
                   .:|::..         |.:|.|.  |.||     .||    ||..:|   |.|  .:.
Mouse   316 LNEGQLLFSHEDSSFQMFSSKAYSQKNLLFKDSTLE-----LVP----IATQNYEAWLGQ--EYL 369

  Fly   357 SAYSFPECNP---PRSIVFCTTSIIQHIKCSWLQEASQVYGVQPNIQCVRTMDEQQCLDNTKFKE 418
            .|.....|:|   |..:.:|..|..:..||..:..|.....::|.||||.....:.|::..:...
Mouse   370 QAMKGLLCDPNRLPHYLRWCVLSAPEIQKCGDMAVAFSRQNLKPEIQCVSAESPEHCMEQIQAGH 434

  Fly   419 TDVVLVDQEMRVKAQRDYNLVPLLYEFAA--DMHDRYVTIALVHKDAKFE-SFRDLKGARACLPS 480
            ||.|.:..|...:|.:.|.|||...|..|  |..:.|..:|:..:|:.:. :..:|:|.|:|.|.
Mouse   435 TDAVTLRGEDIYRAGKVYGLVPAAGELYAEEDRSNSYFVVAVARRDSSYSFTLDELRGKRSCHPY 499

  Fly   481 FEGAAHLSVQETIVNATGKVQ--------SLHSYFHRDS----------------CLWNLQSGRK 521
            ....|...|....:...|.::        ::..:|:...                |:.:.:...|
Mouse   500 LGSPAGWEVPIGSLIQRGFIRPKDCDVLTAVSQFFNASCVPVNNPKNYPSALCALCVGDEKGRNK 564

  Fly   522 C----PLHYQGDEGALRCLSEGA-DVAFLSSDVYKKYVVGNLTSNWLTPGNHKDFRVLCPYGGIE 581
            |    ...|.|..||.|||.|.| ||||:......:...|:....|.:....:|:.:|||.|...
Mouse   565 CVGSSQERYYGYSGAFRCLVEHAGDVAFVKHTTVFENTNGHNPEPWASHLRWQDYELLCPNGARA 629

  Fly   582 KRSNFEYCYLHWTTRGHLMTHNSSLTRRNEIYNSLRDMDQLFGRKYKSETRPFTLYGIFDKRNNV 646
            :...|:.|.|     ..:.:|...:                     :.:|..||:||:.||..:
Mouse   630 EVDQFQACNL-----AQMPSHAVMV---------------------RPDTNIFTVYGLLDKAQD- 667

  Fly   647 LFRDDTDGLLGLQELHRDNAKRVMEHIYDRYANTQYY 683
            ||.||          |..|.       :..:.:::|:
Mouse   668 LFGDD----------HNKNG-------FQMFDSSKYH 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	87/403 (22%)
		PBP2_transferrin	369..681	CDD:270247	75/343 (22%)
		TR_FER	370..656	CDD:214514	73/317 (23%)
Meltf	XP_006522295.1	Transferrin	23..377	CDD:366081	81/383 (21%)
Meltf	XP_006522295.1	TR_FER	387..724	CDD:214514	76/345 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880