DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf3 and zgc:172271

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001107938.1	Gene:	zgc:172271 / 100000381	ZFINID:	ZDB-GENE-080204-110	Length:	733	Species:	Danio rerio

Alignment Length:	739	Identity:	164/739 - (22%)
Similarity:	267/739 - (36%)	Gaps:	174/739 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LRVCVVESRGVYRKTPKFCPLLEAK-----------------------SNIECVIGVDRLDCVRR 73
            |.:|.:.|.|   |..::|.:.||:                       :.:.||......||:.:
Zfish    13 LLLCSITSWG---KKMRWCAVSEAEQKKCAELAKALVAVLPPAAVTAFARLSCVKAYSTADCINK 74

  Fly    74 IHKGTAHFGVLTSEDLVAARWASVEILVASELRSHESHFEYE------IVAVVDNHANIHTVHDL 132
            |....|....|.:.::.:|.......:||.|:        |.      .||||.|.::: .:..|
Zfish    75 IRDNKADLVTLDAGEVYSAVKQFGLTVVAKEI--------YRDGGCILAVAVVRNSSSL-DMRSL 130

  Fly   133 RGARLCHPGYGLGNHWTEVLANYFEAAMVSKTCDPEMTVTEDRIASTA--KYFGPSCKAGPWVPD 195
            :|:|.||.|......|:..|.:     ::|:...|   ..||...|.|  .:|..||..|
Zfish   131 QGSRSCHSGARWTAGWSLPLGH-----LLSRNLLP---WAEDEPISQAVSAFFNASCVPG----- 182

  Fly   196 PKQDRILKNRYPSLCEMCYEPDS--------CD--QTDKHWGRRGALYCLTSGGGNVAWARLDDV 250
                  ......:||.:|....|        |:  .::..:..:|||.||.||.|::|:.
Zfish   183 ------ATTMAANLCSLCKGQRSYIRQKNFHCETSHSEPFYHNQGALRCLQSGAGDIAFV----- 236

  Fly   251 RSHFGFSGIPAQSNPSDFSYLCPDGHLQPLNASQPCVWVAKPWPVVAARRS---------HAAQV 306
             .|....||. :....:...||.||.|.||::.:.|.....|...|..|.:         .|||:
Zfish   237 -DHTALDGID-EREKDELRLLCTDGSLAPLSSFRTCNLGRGPGGGVVTRMNIRKIARKFLVAAQM 299

  Fly   307 QRLVTGLNHDEPDSWQNA------LL--SLLETYHVFTVPLD--NVIAIDDYLDQATAFQSAYSF 361
            .....|........:::|      ||  .:.|...|....:|  .|:.: ||:    |.......
Zfish   300 SFGWRGRERRRFQLFESASFGGSDLLFRDVTEKLSVLMEDMDMSQVLGL-DYV----ALLKGLGH 359

  Fly   362 PECNPPRSIV-FCTTSIIQHIKC-SWLQEASQVYGVQPN-IQCVRTMDEQQCLDNTKFKETDVVL 423
            ...:...|:| :|..|..:..|| .|      ...::.: :.||:......|::..|..|.|.|.
Zfish   360 EGSSLEDSVVRWCCISHAEQKKCEQW------AISIKSDPLVCVKASSMSDCIEKIKRDEVDAVS 418

  Fly   424 VDQEMRVKAQRDYNLVPLLYEFAADMHDR---------------YVTIALVHKDAKFESFRDLKG 473
            :|......|.: ..|||::.|:..:..:.               ...:|:|.:.:|...|..|..
Zfish   419 LDATHAFIAGK-CGLVPVVTEYYGEKCETSAGAGGHFESNELPPVYGVAVVRRSSKSLFFGSLAD 482

  Fly   474 ARACLPSFEGAAH--LSVQETIV-----NATGKVQSLHSYFHRDSCLWNLQSGRKCPL------- 524
            .|:|.......|.  |.|:.|:.     :|..:...::|......||...| |..|.:
Zfish   483 RRSCHSHMYSPAGWVLPVRHTLSTEHNNSAPCEPNKVYSEVFWKGCLPGGQ-GNLCKVCMGGTEE 546

  Fly   525 ------------HYQGDEGALRCL------SEGADVAFLSSDVYKKYVVGNLTSNWLTPGNHKDF 571
                        .|.|:.||||||      ....||||:.....:..:....||.|.......||
Zfish   547 AATKRCADNHNERYYGNMGALRCLVGDPTGKSFGDVAFMEHHNLESNIERLNTSGWAEGWVTWDF 611

  Fly   572 RVLCPYGGIEKRSNFEYCYLHWTTRGHLMTHNSSLTRRNEIYNSLRDMDQLFGRKYKSETRPFTL 636
            .:||..|.....|.::.|.|.......:|| ...||.|  ||      |.|...:..:|.||.:.
Zfish   612 ELLCSDGSRAPLSQWKSCNLGAVPPNIVMT-RPVLTAR--IY------DLLMKSQDTTEARPHSG 667

  Fly   637 YGIFDKR----NNVLFRDDTDGLL 656
            :.:|:.:    :::||:|.|..|:
Zfish   668 FHLFESQQYGESDLLFKDVTKCLV 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	84/394 (21%)
		PBP2_transferrin	369..681	CDD:270247	79/342 (23%)
		TR_FER	370..656	CDD:214514	77/339 (23%)
zgc:172271	NP_001107938.1	PBP2_transferrin	25..357	CDD:270247	80/371 (22%)
		TR_FER	26..357	CDD:214514	80/370 (22%)
		TR_FER	369..713	CDD:214514	78/340 (23%)
		PBP2_transferrin	369..713	CDD:270247	78/340 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.980