Protein Alignment caly and Bap1

DIOPT Version :10

• Sequence 1: NP_611096.1
• Gene: caly / 36794
• FlyBaseID: FBgn0262166
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_001100762.1
• Gene: Bap1 / 306257
• RGDID: 1311938
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 779
• Identity: 226/779 - (29%)
• Similarity: 293/779 - (37%)
• Gaps: 394/779 - (50%)

  Fly    45 GWLELESDPGLFTLLLKDF-------------GCHDVQVEEVYDLQKPIESP-YGFIFLFRWIEE 95
            |||||||||||||||::||             |...|||||:||||...:.| |||||||:||||
  Rat     4 GWLELESDPGLFTLLVEDFGKNPFTPDRRALAGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEE 68

  Fly    96 RRARRKIVETTAEIFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGDTLSRLKTH 160
            ||:|||:.....:..|.|::.::|:|||.|::||||||||||||||||  :|:.||.||||:|..
  Rat    69 RRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPNSCATHALLSVLLNC--SNVDLGPTLSRMKDF 131

  Fly   161 TKGMSPENKGLAIGNTPELACAHNSHAMPQARRRLERTGAGVSSCRFTGEAFHFVSFVPINGQLF 225
            |||.|||:||.||||.||||.||||||.|:.|...|:.. |:|:.| |.|||||||:|||.|:||
  Rat   132 TKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQN-GLSAVR-TMEAFHFVSYVPITGRLF 194

  Fly   226 ELDGLKPYPMNHGGWEDSEDWTDKFRRVMAERLGIAT-GE--QDIRFNLMAVVPDRRIAITHKLK 287
            ||||||.||::||.|.:.|:||||.|||:.||:|:|| ||  .||||||||||||||:....:|.
  Rat   195 ELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRVKYEARLH 259

  Fly   288 MLRTNQAIVSGTLQKLLK----------------------------------------------- 305
            :|:.|:..|...||:|::
  Rat   260 VLKGNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPFGLEAGRTPAASECTHTD 324

  Fly   306 -ADE-----------------------QGESGNG------------------------------- 315
             |:|                       .|.|.||
  Rat   325 GAEEVAGSCPQTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQRLPAFLDNHNYAKSPMQEEED 389

  Fly   316 ----------------------------------------------------------------- 315
                                                                             
  Rat   390 LAAGVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSAIRYKRKGTGKPGSLSNSSDGQLSVLQPN 454

  Fly   316 ----------DSQ---------------------------------------------------- 318
                      :||
  Rat   455 TINVLTEKLQESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLR 519

  Fly   319 ---------RPDTPTT--------------------------------------------LLEPS 330
                     ||.:|.|                                            :|.|.
  Rat   520 SPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPL 584

  Fly   331 AFT----------------------------------------------------ARDLQSLLKN 343
            |.|                                                    .::|.:|||.
  Rat   585 ALTEGGKGSSPSTRSSQGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEKYSPKELLALLKC 649

  Fly   344 LDTEIAINEQHLADENDRRHMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVSQHLLPSKKVS 408
            ::.|||..|..|.:|.::|..||:|..|||||||:|||||:||||.:|:|..||.|::...::
  Rat   650 VEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRR-- 712

  Fly   409 GQGAA-NRISKQSTTASAGGSTAAGTASTPKTQQQQAAAAKNGKSPSKTPGRRRKGRNKCRKRK 471
             ||.: .|:.||                                   :.|.||::.|....||:
  Rat   713 -QGVSIGRLHKQ-----------------------------------RKPDRRKRSRPYKAKRQ 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caly	NP_611096.1	Peptidase_C12_UCH37_BAP1	46..274	CDD:187738	149/244 (61%)
		UCH_C	348..393	CDD:465622	26/44 (59%)
Bap1	NP_001100762.1	Peptidase_C12_UCH37_BAP1	5..246	CDD:187738	149/244 (61%)
		Arg-finger motif. /evidence=ECO:0000250|UniProtKB:Q92560	69..73		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..364		6/77 (8%)
		HBM-like motif. /evidence=ECO:0000250|UniProtKB:Q92560	376..379		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..448		0/62 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..535		3/59 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..635		1/48 (2%)
		Interaction with BRCA1. /evidence=ECO:0000250|UniProtKB:Q92560	607..732		43/162 (27%)
		Interaction with YY1. /evidence=ECO:0000250|UniProtKB:Q92560	653..697		26/43 (60%)
		UCH_C	654..699	CDD:465622	26/44 (59%)
		Classical bipartite Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:Q92560	710..733		8/60 (13%)
		Interaction with nucleosomal DNA forming a DNA clamp with ASXL1. /evidence=ECO:0000250|UniProtKB:Q92560	710..712		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..740		8/59 (14%)
		Positively charged C-terminal extension (CTE). /evidence=ECO:0000250|UniProtKB:Q92560	724..740		5/15 (33%)
		Non-classical PY-nuclear localization signal (PY-NLS). /evidence=ECO:0000250|UniProtKB:Q92560	728..735		3/6 (50%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q92560	728..733		2/4 (50%)