Protein Alignment caly and Bap1

DIOPT Version :10

• Sequence 1: NP_611096.1
• Gene: caly / 36794
• FlyBaseID: FBgn0262166
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_081364.1
• Gene: Bap1 / 104416
• MGIID: 1206586
• Length: 728
• Species: Mus musculus
• Alignment Length: 767
• Identity: 226/767 - (29%)
• Similarity: 293/767 - (38%)
• Gaps: 382/767 - (49%)

  Fly    45 GWLELESDPGLFTLLLKDFGCHDVQVEEVYDLQKPIESP-YGFIFLFRWIEERRARRKIVETTAE 108
            |||||||||||||||::|||...|||||:||||...:.| |||||||:||||||:|||:.....:
Mouse     4 GWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDD 68

  Fly   109 IFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGDTLSRLKTHTKGMSPENKGLAI 173
            ..|.|::.::::|||.|::||||||||||||||||  :|:.||.||||:|..|||.|||:||.||
Mouse    69 TSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNC--SNVDLGPTLSRMKDFTKGFSPESKGYAI 131

  Fly   174 GNTPELACAHNSHAMPQARRRLERTGAGVSSCRFTGEAFHFVSFVPINGQLFELDGLKPYPMNHG 238
            ||.||||.||||||.|:.|...|:.. |:|:.| |.|||||||:|||.|:||||||||.||::||
Mouse   132 GNAPELAKAHNSHARPEPRHLPEKQN-GLSAVR-TMEAFHFVSYVPITGRLFELDGLKVYPIDHG 194

  Fly   239 GWEDSEDWTDKFRRVMAERLGIAT-GE--QDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTL 300
            .|.:.|:||||.|||:.||:|:|| ||  .|||||||||||||||....:|.:|:.|:..|...|
Mouse   195 PWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYETRLHVLKVNRQTVLEAL 259

  Fly   301 QKLLK------------------------------------------------ADE--------- 308
            |:|::                                                |:|
Mouse   260 QQLIRVTQPELIQTHKSQESQLPEESKPASSKSPLGLEAGRTPVASECTQTDGAEEVAGSCPQTT 324

  Fly   309 --------------QGESGNG-------------------------------------------- 315
                          .|.|.||
Mouse   325 THSPPSKCKLVVKPPGSSLNGVPPNPAPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVR 389

  Fly   316 ---------------------------------------------------------------DS 317
                                                                           :|
Mouse   390 APQQYSEDEDDYEDEDEDVQNTNPAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQES 454

  Fly   318 Q-------------------------------------------------------------RPD 321
            |                                                             ||.
Mouse   455 QKDLSVPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPS 519

  Fly   322 TPTT--------------------------------------------LLEPSAFT--------- 333
            :|.|                                            :|.|.|.|
Mouse   520 SPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPS 584

  Fly   334 -------------------------------------------ARDLQSLLKNLDTEIAINEQHL 355
                                                       .::|.:|||.::.|||..|..|
Mouse   585 TRSSQGSQGSSGLEEKEVVEVTESRDKPGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYEACL 649

  Fly   356 ADENDRRHMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVSQHLLPSKKVSGQGAA-NRISKQ 419
            .:|.::|..||:|..|||||||:|||||:||||.:|:|..||.|::...::   ||.: .|:.||
Mouse   650 KEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRR---QGVSIGRLHKQ 711

  Fly   420 STTASAGGSTAAGTASTPKTQQQQAAAAKNGKSPSKTPGRRRKGRNKCRKRK 471
                                               :.|.||::.|....||:
Mouse   712 -----------------------------------RKPDRRKRSRPYKAKRQ 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caly	NP_611096.1	Peptidase_C12_UCH37_BAP1	46..274	CDD:187738	148/231 (64%)
		UCH_C	348..393	CDD:465622	26/44 (59%)
Bap1	NP_081364.1	Peptidase_C12_UCH37_BAP1	5..233	CDD:187738	148/231 (64%)
		Arg-finger motif. /evidence=ECO:0000250|UniProtKB:Q92560	56..60		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..333		2/59 (3%)
		HBM-like motif. /evidence=ECO:0000250|UniProtKB:Q92560	363..366		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..436		0/63 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	463..523		3/59 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..623		1/48 (2%)
		Interaction with BRCA1. /evidence=ECO:0000250|UniProtKB:Q92560	595..720		43/162 (27%)
		Interaction with YY1. /evidence=ECO:0000250|UniProtKB:Q92560	641..685		26/43 (60%)
		UCH_C	642..687	CDD:465622	26/44 (59%)
		Classical bipartite Nuclear localization signal (NLS). /evidence=ECO:0000250|UniProtKB:Q92560	698..721		8/60 (13%)
		Interaction with nucleosomal DNA forming a DNA clamp with ASXL1. /evidence=ECO:0000250|UniProtKB:Q92560	698..700		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	702..728		9/60 (15%)
		Positively charged C-terminal extension (CTE). /evidence=ECO:0000250|UniProtKB:Q92560	712..728		5/15 (33%)
		Non-classical PY-nuclear localization signal (PY-NLS). /evidence=ECO:0000250|UniProtKB:Q92560	716..723		3/6 (50%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q92560	716..721		2/4 (50%)