DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment clu and cluha

DIOPT Version :10

Sequence 1:NP_611095.1 Gene:clu / 36793 FlyBaseID:FBgn0034087 Length:1448 Species:Drosophila melanogaster
Sequence 2:NP_001071028.1 Gene:cluha / 562666 ZFINID:ZDB-GENE-061103-457 Length:1400 Species:Danio rerio


Alignment Length:1400 Identity:746/1400 - (53%)
Similarity:992/1400 - (70%) Gaps:121/1400 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 AADGPAAKKKGKKNRNKSPTEPTTEAVLSNGHAEKPTVV--DAVEDNADTNANVEKPQEG-GAPD 123
            |.||..|..||        |....||..:.||..:..|:  ||..|.|:   ..:..|:| |..|
Zfish    21 ARDGETANSKG--------TTSKKEASCACGHGVETAVMNGDAGHDQAE---EADSKQDGSGDAD 74

  Fly   124 AEADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDN 188
            ...|.::.::..:||.|.||.|.:||.:...:|:|..|:||||||:|||||:||||||||||||.
Zfish    75 QAEDANEQEVIVIQDTGFTVKIQAPGTEPFDLQVSPQEMVQEIHQVLMDREDTCHRTCFSLQLDG 139

  Fly   189 VTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLN 253
            ..||||||||||..|::||.:||||||||:|||||||||:|||||:|||:|||||:||.||::|:
Zfish   140 NVLDNFAELKSIEGLQEGSLLKVVEEPYTVREARIHVRHIRDLLKSLDPSDAYNGVDCNSLSFLS 204

  Fly   254 TITQGDLLD-----KKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNVKNAKGPQALKVLTTSAWN 313
            ..::|||.|     ||.:..:.:||||||::.||..:.|::||.|..|:.|..|.|||||.|:||
Zfish   205 VFSEGDLGDTGKRKKKGSELEQIDCTPPEHILPGSKERPLVPLQPQNKDWKPMQCLKVLTMSSWN 269

  Fly   314 PPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHI 378
            ||||.||:||||||||:||:||:...|:|.::||::||||...|:|||.|||.|||||::|||.|
Zfish   270 PPPGNRKMHGDLMYLYIVTVEDRHVSITASTRGFYLNQSTTYNFSPKPANPSFLSHSLVELLSQI 334

  Fly   379 SPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIPGQT 443
            |.:|::.|.|:||:|..||.|||:|||:|||.|.||.::|.:|.:|||||::|:|||||||||||
Zfish   335 SAAFKKNFTTLQKKRVQRHPFERIATPFQVYSWTAPQIDHAMDCVRAEDAYTSRLGYEEHIPGQT 399

  Fly   444 RDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMF 508
            |||||||||||||.||.|||||||||||||||.||..||||||||||||||:||||||:|:||||
Zfish   400 RDWNEELQTTRELSRKNLPERLLRERAIFKVHSDFAAAATRGAMAVIDGNVMAINPGEETRMQMF 464

  Fly   509 IWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTA 573
            ||||||||:||||||||:|||||:||..||..||:|||.|:|||:||||||||||||||||||||
Zfish   465 IWNNIFFSLGFDVRDHYRELGGDSAAHAAPTNDLNGVRAYSAVDVEGLYTLGTVVVDYRGYRVTA 529

  Fly   574 QSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSV 638
            ||||||||||||||||:||||||||||:|||||||||.:..:.||:..|.||||:|..|||||||
Zfish   530 QSIIPGILEREQEQSVIYGSIDFGKTVVSHPKYLELLEKTSRPLKVQRHAVLNEKDSAVELCSSV 594

  Fly   639 ECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEAFIE 703
            ||||||||||||||||||||||||:|||.::..:|:.|...:|||.:|||:|.||||||:|||:|
Zfish   595 ECKGIIGNDGRHYILDLLRTFPPDLNFLPVEGEELTPESQKLGFPRQHRHRLACLRQELIEAFVE 659

  Fly   704 DRHVNFIRIAAARLQQLTTIKQS----------------------------------------EK 728
            .|::.|:::||.:|.|....|..                                        |.
Zfish   660 HRYLLFMKMAALQLMQQKANKDKTAALQDSNAAGAGSENKPLALESCDGTPDSPTSSESTLTPED 724

  Fly   729 SEANPV---PALEGAEAASKV-----NGAEKPDDKEKKNE------EEEKKERSTSGEARAAAIV 779
            |||..|   .:.|..||.::|     ||..:|...|::|.      |.::.:.:..|.|:|..:.
Zfish   725 SEATTVSENSSAENQEAMTEVPVASINGTHEPLAAERQNGGCDGPLEGKEADENIPGLAQAKELA 789

  Fly   780 NAI-REAQSNVATSNEVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSPGIRHADGEEGTSLAKQ 843
            .:: .|..|.:    :.::.|||..||.||||:....||.|||||:||||:|..| :....:.||
Zfish   790 ESLAAEDGSGI----DPKSREVVLNACKAVGSISNTSFDIRFNPDIFSPGVRFPD-DSNDDIKKQ 849

  Fly   844 KVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMP---R 905
            |.|:::||.|||..|||:.:|:.:.|||.|:||.:|||:||..||||||||.|::.:..||   :
Zfish   850 KQLLKDAAAFLVSCQIPSLVKDCLDHSSLPMDGATLTEALHQRGINVRYLGTVLEFMDNMPAKAQ 914

  Fly   906 MDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTNG-------PVNPAVSSEE 963
            :::::||.:.|||.|..|||:.||:|..:...||||:|:||||||::.       |.:..||.::
Zfish   915 LEHIYRIGISELITRCAKHIFKTYLQGVDLSALSAAVSYFLNCLLSSFPDAVAHLPADELVSRKK 979

  Fly   964 AHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSASDWTLMTPRSLWQQIRKEAK 1028
            :.|:|                           |....|..|::    |..:||..||:.|..||.
Zfish   980 SRKRR---------------------------NRVPGGGDNTA----WASLTPSELWKNITSEAH 1013

  Fly  1029 VYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTFGDDDIVNVFPIV 1093
            .|:::.|.|:|::.||.|||:.:|:|:|...:|.|||:|::||||:|:|||.|.::||:|:||:|
Zfish  1014 GYYNFSLQCESVDQAVEKYGLQKITLLREISIKTGIQILIKEYNFDSRHKPAFTEEDILNIFPVV 1078

  Fly  1094 KHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLL 1158
            ||::|:|:||::|:.:||||:|||..|||.|||:.||||.|||:||:|.|..:|||:||||:|::
Zfish  1079 KHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLNYIM 1143

  Fly  1159 GDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGE 1223
            ||..:||:.||:||:|||||.|::||:||.||.||:||.||||.:..:|||||||||||:::|||
Zfish  1144 GDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANGQLSTALKLLYRARYLMLVVCGE 1208

  Fly  1224 DHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCMGDFR 1288
            ||||:||:||||.|:||.:.||:|||||:|:||.:|.||.|.:.:.||||:||:||......:||
Zfish  1209 DHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRSLKVALSHHLVARVYESKAEFR 1273

  Fly  1289 SALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGKLTSDLPPIHITP 1353
            |||.:|||.|:.||:|:||.||||::|:|.|:.||||||.|||.||:||.:|. .:.:.|:..|.
Zfish  1274 SALQHEKEGYTIYKNQVGEAHEKTKESSEYLKYLTQQAVALQRTMNEIYKNGS-NASIMPLKFTA 1337

  Fly  1354 PSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEK 1388
            |||.|||:.||.||||:|:.:|:||:..:::|:::
Zfish  1338 PSMASVLEQLNIINGIIFIPLSQKDLENLKAEVQR 1372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cluNP_611095.1 CLU_N 163..232 CDD:464466 55/68 (81%)
GSKIP_dom <324..387 CDD:398795 36/62 (58%)
CLU 445..665 CDD:463814 184/219 (84%)
eIF3_p135 870..1073 CDD:463717 79/212 (37%)
FxSxx_TPR <1117..1309 CDD:468560 117/191 (61%)
TPR repeat 1190..1215 CDD:276809 16/24 (67%)
TPR repeat 1228..1258 CDD:276809 19/29 (66%)
cluhaNP_001071028.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 8/25 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 56..78 6/24 (25%)
CLU_N 110..183 CDD:464466 56/72 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..243 11/30 (37%)
CLU 401..621 CDD:463814 184/219 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..741 6/56 (11%)
eIF3_p135 876..1058 CDD:463717 79/212 (37%)
TPR 1 1088..1121 20/32 (63%)
FxSxx_TPR <1109..1294 CDD:468560 113/184 (61%)
TPR 2 1130..1163 19/32 (59%)
TPR repeat 1132..1158 CDD:276809 15/25 (60%)
TPR 3 1172..1205 22/32 (69%)
TPR repeat 1172..1200 CDD:276809 18/27 (67%)
TPR_12 1212..1288 CDD:315987 42/75 (56%)
TPR repeat 1213..1243 CDD:276809 19/29 (66%)
TPR 4 1214..1247 20/32 (63%)
TPR repeat 1256..1281 CDD:276809 13/24 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1377..1400
Blue background indicates that the domain is not in the aligned region.

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