Protein Alignment clu and Cluh

DIOPT Version :10

• Sequence 1: NP_611095.1
• Gene: clu / 36793
• FlyBaseID: FBgn0034087
• Length: 1448
• Species: Drosophila melanogaster
• Sequence 2: XP_063125121.1
• Gene: Cluh / 303300
• RGDID: 1307222
• Length: 1518
• Species: Rattus norvegicus
• Alignment Length: 1467
• Identity: 747/1467 - (50%)
• Similarity: 1016/1467 - (69%)
• Gaps: 102/1467 - (6%)

  Fly     3 LETEAKNSNATATGDATATATKASGKAKENNNTAGGKKNLNPNSNQQNSNQNLVNGNGTAADGP- 66
            |:.||..|::....:...|..:|....::..:...| ....|.|...       :|.|..:..|
  Rat   127 LKPEASWSSSPEPTNCITTVIEAETGTRDRGSIGPG-PGPGPGSGPG-------SGPGQGSWRPY 183

  Fly    67 --AAKKKGKKNRNKSPTEPTTEAV-LSNGHAEKPTVVDAVEDNADTNANVEKPQEG----GAPDA 124
              .:.:..:..|.:..|.|...:| |.||        |..|:......:.|.|:|.    |.|..
  Rat   184 CHGSSETPEPRRGQLLTVPDPPSVMLLNG--------DCSENLKKEEGSSEPPRENGLDEGEPGE 240

  Fly   125 EADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDNV 189
            |..|.::.:  :||.|.:|.|.:||.:...:|:|..|:||||||:|||||:|||||||||.||..
  Rat   241 ETTGQEVIV--IQDTGFSVKILAPGIEPFSLQVSPQEMVQEIHQVLMDREDTCHRTCFSLHLDGN 303

  Fly   190 TLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLNT 254
            .||:|:||:|:..|::||.::|||||||:|||||||||||||||:|||:||:||:||.||::|:.
  Rat   304 MLDHFSELRSVEGLQEGSVLRVVEEPYTVREARIHVRHVRDLLKSLDPSDAFNGVDCNSLSFLSV 368

  Fly   255 ITQGDLLD----KKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNVKNAKGPQALKVLTTSAWNPP 315
            .|.|||.|    ||....|.:|||||||:.||..:.|:.||.|..::.|..|.|||||.|.||||
  Rat   369 FTDGDLGDSGKRKKGLEMDPIDCTPPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMSGWNPP 433

  Fly   316 PGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHISP 380
            ||.||:|||||||:|:|.||::..::|.::||::||||...|||||.:|..|||||::||:.|||
  Rat   434 PGNRKMHGDLMYLFVITAEDRQVSVTASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELLNQISP 498

  Fly   381 SFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIPGQTRD 445
            :|::.|..:||:|..||.|||:|||:|||.|.||..||.:|.:|||||::|:|||||||||||||
  Rat   499 TFKKNFAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQTRD 563

  Fly   446 WNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMFIW 510
            ||||||||||||||.|||||||||||||||.||..||||||||||||||:||||.|:||||||||
  Rat   564 WNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIW 628

  Fly   511 NNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTAQS 575
            ||||||:|||||||||:.|||.||:|||..||:|||.|||||:||||||||||||||||||||||
  Rat   629 NNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQS 693

  Fly   576 IIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSVEC 640
            ||||||||:|||||:||||||||||:|||:|||||.:..:.||||.|.|||:|||.|||||||||
  Rat   694 IIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPLKILRHRVLNDRDEEVELCSSVEC 758

  Fly   641 KGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEAFIEDR 705
            ||||||||||||||||||||||:|||.:...:|.:|....|||..||||||||||||::||:|.|
  Rat   759 KGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPEECSRAGFPRTHRHKLCCLRQELVDAFVEHR 823

  Fly   706 HVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAEKPDDKEKKNEEEEKKERSTS 770
            ::.|:::||.:|.      |.:.|:.:...:||        ||. .|...|.|:|:....|....
  Rat   824 YLLFMKLAALQLM------QQKASKVDTSTSLE--------NGG-PPSSTETKSEDSLGSEAGCE 873

  Fly   771 GEARAAAIVNAIREAQSNVATSN---EVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSPGIRHA 832
            .|..:.:.:..::|....:|:.:   :.::.||::.||.||||:....||.|||||:||||:|..
  Rat   874 EEGSSVSGLAKVKELAETIASDDGTVDPRSREVIQNACKAVGSVSSTAFDIRFNPDIFSPGVRFP 938

  Fly   833 DGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTESLHSHGINVRYLGKVI 897
            :..: ..:..||.|:::||.||:..|||..:|:...::..|:||.:|.|.:...|||:||||||:
  Rat   939 ESCQ-DEVRDQKQLLKDAAAFLLSCQIPGLVKDCTEYAVLPMDGATLAEVMRQRGINMRYLGKVL 1002

  Fly   898 KILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTNGPVNPAV 959
            .::.:.|   ::|::::|.:.|||.|:.|||:.||:|..|...|||||||||||.|::.| ||..
  Rat  1003 DLVLRSPARDQLDHIYKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYP-NPVA 1066

  Fly   960 ---SSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSASDWTLMTPRSLWQ 1021
               :.|...|||      ||.:.::                 ..|::::::   |.:|||:.||:
  Rat  1067 HLPADELLSKKR------NKRRKNR-----------------PPGAADNTA---WAVMTPQELWK 1105

  Fly  1022 QIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTFGDDDI 1086
            .|.:|||.|:|:.|:|||::.||..||:.:|:|:|...||.|:|:||:||:|:|:|||.|.::|:
  Rat  1106 NICQEAKNYFDFTLECDSVDQAVETYGLQKITLLREISLKTGMQILLKEYSFDSRHKPAFTEEDV 1170

  Fly  1087 VNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRML 1151
            :|:||:|||::|:|:||::|:.:||||:|||..|||.|||:.||||.|||:||:|.|..:|||:|
  Rat  1171 LNIFPVVKHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICACLRLL 1235

  Fly  1152 ARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYL 1216
            |||.|::||..:||:.||:||:|||||.|::||:||.||.||:||.||:..:..:|.||||||||
  Rat  1236 ARLHYIMGDYAEALSNQQKAVLMSERVVGIEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYL 1300

  Fly  1217 MVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQ 1281
            |:|:.||||||:||:|:||.|:||.:.||:|||||:|:||.:..||.|.|.:.||||:||:||..
  Rat  1301 MLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVTTKYHGPKALKVALSHHLVARVY 1365

  Fly  1282 SCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGKLTSDL 1346
            ....:|||||.:|||.|:.||:||||:|||||:|:|.|:.||||||.|||.||:||.:|. ::::
  Rat  1366 ESKAEFRSALQHEKEGYTIYKTQLGEDHEKTRESSEYLKCLTQQAVALQRTMNEIYRNGS-SANI 1429

  Fly  1347 PPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFKTDSTENEVNDAINSIVAAAN 1411
            ||:..|.|||.|||:.||.||||||:.:|:||:..:::|:.:.              :.:..|:.
  Rat  1430 PPLKFTAPSMASVLEQLNVINGILFIPLSQKDLENLKAEVARR--------------HQLQEASR 1480

  Fly  1412 NNGEAEDAVSKDIKEQPEAGKQLTN-GDKAAATEATS 1447
            |..:||:.::    .:||..:.|.. |....|.|..|
  Rat  1481 NRDKAEEPMA----TEPEPDRALEGMGSPQTAKEGPS 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	163..232	CDD:464466	50/68 (74%)
		GSKIP_dom	<324..387	CDD:398795	33/62 (53%)
		CLU	445..665	CDD:463814	187/219 (85%)
		eIF3_p135	870..1073	CDD:463717	81/208 (39%)
		FxSxx_TPR	<1117..1309	CDD:468560	114/191 (60%)
		TPR repeat	1190..1215	CDD:276809	13/24 (54%)
		TPR repeat	1228..1258	CDD:276809	18/29 (62%)
Cluh	XP_063125121.1	None