Protein Alignment clu and clu1

DIOPT Version :10

• Sequence 1: NP_611095.1
• Gene: clu / 36793
• FlyBaseID: FBgn0034087
• Length: 1448
• Species: Drosophila melanogaster
• Sequence 2: NP_595319.2
• Gene: clu1 / 2540905
• PomBaseID: SPBC530.06C
• Length: 1173
• Species: Schizosaccharomyces pombe
• Alignment Length: 1291
• Identity: 347/1291 - (26%)
• Similarity: 566/1291 - (43%)
• Gaps: 206/1291 - (15%)

  Fly   116 PQEGGAPD-AEADGDDIDLDALQDIGITVNISSPG-ADLLCVQLSSMELVQEIHQLLMDREETCH 178
            |...|.|. .|....|:      |:.:.:::..|. ...|...|.....:.::.|::::......
pombe    12 PGSSGDPSGTEMSHSDV------DVSVDIDVIFPDHTQTLSFSLLLSNTIHDVRQVILELMLAPP 70

  Fly   179 RTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVEE----PYTMREARIHVRHVRDLLKNLDPAD 239
            .|||.|:.....|.:|.|:..|.:|:...|.|:|.|    |||.||::.|:..:.:.|....|:.
pombe    71 HTCFHLEYKREKLHSFLEIGQIPHLKLSKTRKIVLEVVLDPYTERESKYHIYTLLEFLSRKLPSS 135

  Fly   240 AYN-GIDCTSLTY--LNTITQGDLLDKKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNVKNAKGP 301
            :.: ||......:  ||..:..:|..|..:..:.::..|...||..:|...:|.......|....
pombe   136 STSPGIRAGFCIFPSLNIPSGENLQIKSSSSLEEINKIPENIVTQSLSYTNLLKKFETSPNPSNN 200

  Fly   302 QALKVLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSH 366
            ...:.|..|.|||.|....:.|.|:||.|:|:|.|.::|::...||::|..|...|:|.|.:...
pombe   201 GCFRSLALSGWNPVPAEFVIQGHLLYLTVLTIEGKTYNITSHVSGFYVNNCTSTKFDPSPCDDLQ 265

  Fly   367 LSHSLIDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQ--WAAPILEHTVDAIRAEDAF 429
             ||||:.||..:||.|:..............|..:.:....:.|  |....:.|..|..|.:.
pombe   266 -SHSLVLLLEQLSPLFKERLHLSLNDYKSGDAIAQASITGTLPQAPWITFPVPHRADLSRTQK-- 327

  Fly   430 SSKLGYEEHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNV 494
            |....|.|: .|..||||||:|:|||:..:.:.:|:||||...|...||...|..||:.:::||:
pombe   328 SELFPYIEN-QGNLRDWNEEIQSTREMDHEDVQDRVLRERLTVKTLQDFTDMAVEGAIDMVNGNI 391

  Fly   495 LAINPGEDTKMQMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTL 559
            .::||.|.|..|||:.||||||.|.|....:...|||:||:.|...|:..:|:.|..|:.....|
pombe   392 PSLNPLEPTASQMFVHNNIFFSYGRDSVGIFSTKGGDSAAYSAVGKDILAIRLLNQFDLSNPSLL 456

  Fly   560 GTVVVDYRGYRVTAQSIIPGILEREQEQS--VVYGSIDFGKTVLSHPKYLE-LLRQAGKHLKILP 621
            ||.||||.|:||.||:|:|||.::.:..|  ::||.:: |::.....:..| .|.:....|.|..
pombe   457 GTCVVDYAGHRVVAQTIVPGIFKQLENGSSHLIYGKVE-GESDFRFDESFEGELSRISDLLHIKK 520

  Fly   622 HVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEH 686
            |..::.:::...|.:|::.|.:.|:|||.|::||...||.|..||::...:.::|     || .:
pombe   521 HFFVDGKEKSFPLYTSMDAKALKGSDGRTYLMDLYSLFPLDAQFLEVISDEKNEE-----FP-AY 579

  Fly   687 RHKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAEK 751
            .|||..:|.||::.|.|           .:||.......:...:.|...:|:..|...  ||.:.
pombe   580 PHKLVHVRPELVQLFYE-----------MKLQAFVNANHNAPKKKNLNDSLKSVELEG--NGIKL 631

  Fly   752 PDDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSNEVQAAEVVKRACAAVGSLKEKEF 816
            ..:|.|.|                   ||.:|...:                           .|
pombe   632 SSEKGKNN-------------------VNKVRNDNA---------------------------RF 650

  Fly   817 DFRFNPDVF-SPGIRHADGEE--GTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSS--PIDG 876
            |..||||.| |..|...|.:|  ...:.....|    :::|..:.||.|:|. :|..||  ||||
pombe   651 DCGFNPDCFRSDYIFPPDNKELYDKDIENSYAL----SQYLHAEVIPNFVKS-LSEPSSFLPIDG 710

  Fly   877 QSLTESLHSHGINVRYLGKVIK-ILSQMPRMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSA 940
            .:|..::|..|||:||||::.. ||.:.|....|.::...|:.:|:.||::..::.....:..|.
pombe   711 VALCRAMHRSGINIRYLGEIANIILQKSPNNVILLKLVTSEIFIRSIKHVFRNFLAVVPQVLRSH 775

  Fly   941 AISHFLNCLLT----NGPVNPAVSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSG 1001
            .:||.||.|.|    ..|..|.::...|:                  ...|..|...:.|.:
pombe   776 LLSHLLNNLFTVYGYVEPTKPLINENIAN------------------LFFQATQVIYSINST--- 819

  Fly  1002 SSNSSSASDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQV 1066
                            ||:..|:|||...:.:.|..|.:      :.:..|.::|..||::|||:
pombe   820 ----------------SLYSSIKKEASSRFRFNLTDDLL------HSLNPICILRGTCLRLGIQI 862

  Fly  1067 LLREY-------------------------------------------NFESKHKPTFGDDDIVN 1088
            ..::|                                           ..||:....|...||:|
pombe   863 SCKDYFSNKSDDKICEEHAVPNGSTKFTGKKGNKKKRNLGKSQNTTNRQVESEQINIFRPKDILN 927

  Fly  1089 VFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRMLAR 1153
            :.|::|...|.:..|.......:|.:.||..:..|.|::.:|:|...::|.||.|.......||.
pombe   928 LMPVIKTCIPYSGLAQESLEACKACLLQGNKELCYNLLNESLSLHEQIYGVLHTEVARAYCQLAM 992

  Fly  1154 LSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANG-------HVGMSLKLLY 1211
            :.:.|...::|:.:.::|||:.||..|.|...|.|.|.:||||.|:..       |:..:|||.|
pombe   993 IYHQLEKKEEAVELARKAVIVCERFLGFDSSETSLAYMNLSLYEFSQKNEMQAVMHMQHALKLWY 1057

  Fly  1212 RARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHL 1276
                   |:.|.|||......:|:||:||...::..|.:.::.|:.|:.|.|| |....|..|..
pombe  1058 -------LVFGPDHPNTINSFTNLSLMLHGSEKFIQSQKCLQIAVDLSDKIFG-KTTPTASLYLQ 1114

  Fly  1277 MARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRK 1332
            :|:......|.||||:..:..|...|..||.:|:.|:::...|...|..||..:|:
pombe  1115 LAQLMVLNKDSRSALHAVRVAYDILKETLGPDHQNTKEAEHWLSEFTALAVNQERQ 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	163..232	CDD:464466	20/72 (28%)
		GSKIP_dom	<324..387	CDD:398795	24/62 (39%)
		CLU	445..665	CDD:463814	85/222 (38%)
		eIF3_p135	870..1073	CDD:463717	52/252 (21%)
		FxSxx_TPR	<1117..1309	CDD:468560	62/198 (31%)
		TPR repeat	1190..1215	CDD:276809	11/31 (35%)
		TPR repeat	1228..1258	CDD:276809	7/29 (24%)
clu1	NP_595319.2	CLU_N	52..128	CDD:464466	20/75 (27%)
		CLU	342..564	CDD:463814	85/222 (38%)
		eIF3_p135	704..868	CDD:463717	50/206 (24%)
		TPR_12	951..1011	CDD:315987	15/59 (25%)
		TPR_12	982..1055	CDD:315987	22/72 (31%)
		TPR repeat	984..1012	CDD:276809	5/27 (19%)
		TPR repeat	1017..1055	CDD:276809	12/37 (32%)
		TPR_12	1024..1100	CDD:315987	26/82 (32%)
		TPR repeat	1068..1096	CDD:276809	7/27 (26%)
		TPR repeat	1109..1137	CDD:276809	8/27 (30%)