Protein Alignment clu and clu

DIOPT Version :10

• Sequence 1: NP_611095.1
• Gene: clu / 36793
• FlyBaseID: FBgn0034087
• Length: 1448
• Species: Drosophila melanogaster
• Sequence 2: XP_320668.5
• Gene: clu / 1280801
• VectorBaseID: AGAMI1_010791
• Length: 1482
• Species: Anopheles gambiae
• Alignment Length: 1539
• Identity: 921/1539 - (59%)
• Similarity: 1110/1539 - (72%)
• Gaps: 148/1539 - (9%)

  Fly     1 MALETEAKNSNATATGDATATATKASGKAKENNNTAGGKKNLNPNSNQQNSNQNLVNGNGTAADG 65
            ||||||:..|...||   .|.:|..||:       |||||                  .|.|
Mosquito     1 MALETESVQSAGAAT---EALSTAGSGE-------AGGKK------------------KGMA--- 34

  Fly    66 PAAKKKGKKNRNKSPTEPTTEA-------VLSNGHAEK-------------PTVVDAVEDNADTN 110
                 |.||...|:.|.|...|       .:.|||||:             |......|...|.:
Mosquito    35 -----KNKKQNGKAKTPPVVAAAAGEQKETIGNGHAEQNGLNGHASSEESDPAAAGPNESADDKS 94

  Fly   111 ANVEKPQEGGAPDAEADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREE 175
            |.|....|......:...||: :..:|:.|.||.:.|||.:.|.:|:|||||||||||||||||:
Mosquito    95 AGVAGGGETEQQQQQQQEDDV-MRLMQETGFTVQVLSPGVEPLSIQVSSMELVQEIHQLLMDRED 158

  Fly   176 TCHRTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADA 240
            ||||||||||||..|||||||||:|:.|::||.|:|||||||||||||||||||||||:||||||
Mosquito   159 TCHRTCFSLQLDGRTLDNFAELKNIDGLQEGSVIRVVEEPYTMREARIHVRHVRDLLKSLDPADA 223

  Fly   241 YNGIDCTSLTYLNTITQGDLLDKKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNVKNAKGPQALK 305
            |||:||:|||:|:|||.||:::||:||.:|||||||:::.||..:.|:|||.|.......||.||
Mosquito   224 YNGVDCSSLTFLHTITMGDIMEKKKTRQESVDCTPPDFIMPGARERPLLPLQPGTGKKGTPQPLK 288

  Fly   306 VLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHS 370
            ||||||||||||||||||||||||||||||||.||||||:||::||||||.|||:|.|||:||||
Mosquito   289 VLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRLHISACSRGFYVNQSTDDAFNPQPANPSYLSHS 353

  Fly   371 LIDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGY 435
            ||||||.||.:|||.|..:||:||.||.|||||||||||.|.||.||||:|||||||.|||||||
Mosquito   354 LIDLLSQISATFRRCFAQMQKKRTQRHPFERVATPYQVYTWTAPALEHTIDAIRAEDTFSSKLGY 418

  Fly   436 EEHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPG 500
            |||||||||||||||||||||||.||||||||||||||||.||||||||||||||||||:.||||
Mosquito   419 EEHIPGQTRDWNEELQTTRELPRATLPERLLRERAIFKVHSDFVTAATRGAMAVIDGNVMPINPG 483

  Fly   501 EDTKMQMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVD 565
            ||.|.|||||||||||:||||||||||||||||||||||.||||||||:|||:||||||||||:|
Mosquito   484 EDAKTQMFIWNNIFFSLGFDVRDHYKELGGDAAAFVAPRNDLHGVRVYSAVDVEGLYTLGTVVID 548

  Fly   566 YRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHVVLNERDE 630
            ||||||||||||||||||||:||||||||||||||||||||||||..||||||||||.|.|:::|
Mosquito   549 YRGYRVTAQSIIPGILEREQDQSVVYGSIDFGKTVLSHPKYLELLNAAGKHLKILPHSVYNDKEE 613

  Fly   631 PVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKL--QDVQLSKELVDMGFPIEHRHKLCCL 693
            .:||||||||||||||||||||||||||||||||||.|  ::..:.||...||||||||||||||
Mosquito   614 AIELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLALPAEEEAVGKESRAMGFPIEHRHKLCCL 678

  Fly   694 RQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGA-----EAASKVNGAEKP- 752
            ||||||||:|:|::.|::.||.:|||...:||.:|:.| .....||.     |||:...|.:.|
Mosquito   679 RQELLEAFVENRYLMFMKHAAVQLQQCVKMKQEQKAAA-AQKTEEGGKQAAIEAAAPAEGDKTPA 742

  Fly   753 ----DDKEK-KNEEEEKKERSTSGEARAAAIV----------NAIREAQSNVATSNEVQAAEVVK 802
                |.||. |:..:.|:|.||:.||.|||..          :|.:..:|.:::..:.::.||||
Mosquito   743 KDAKDGKEAGKDANDGKEEGSTTKEAAAAAAAARSVPKPDSEDAKKLVESLISSDQKNESMEVVK 807

  Fly   803 RACAAVGSLKEKEFDFRFNPDVFSPGIRHADGEEGT--SLAKQKVLVQEAAEFLVLKQIPAFIKE 865
            |||.|||||||.||:.||||||:||||||.|.|...  ||.:||.||::||||||..|||:|:.|
Mosquito   808 RACEAVGSLKEYEFNIRFNPDVYSPGIRHVDEEPNAAGSLRRQKQLVKDAAEFLVKHQIPSFVHE 872

  Fly   866 HMSHSSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMPRMDYLHRIAVLELIVRATKHIYYTYM 930
            .:.|:|:|:||.:|||.||:.||||||||||:..|:::.:::|||.|||.||||||.||::..|:
Mosquito   873 CLDHTSAPMDGVTLTELLHNRGINVRYLGKVVDQLAKIKQLEYLHTIAVSELIVRAAKHLFTAYL 937

  Fly   931 QNTEPLHLSAAISHFLNCLLT--NGPVNPAVSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTG 993
            |.|:.:.::|||||||||.||  .|...|..:...|.   |:|...::.....|||.|.:|...|
Mosquito   938 QQTDVMSMAAAISHFLNCFLTVSTGGYQPVANGTGAD---GDGQLADEFGPKAGGKKQNKQSKRG 999

  Fly   994 NQNGSSSGSSN----------SSSASDWTLMTPRSLWQQIRKEAKVYWDWELD------------ 1036
            ...|...|::.          ||...:||.:|.::||.|||:|.|.|||:||.
Mosquito  1000 GGGGGGKGAAGGGRKATFSVPSSDNCEWTALTSKTLWAQIRQELKAYWDFELTVEQPAKEGKESK 1064

  Fly  1037 ---CDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTFGDDDIVNVFPIVKHISP 1098
               .||||..:..:.:.:|||:|:||||.|:|:||:||.||.:::|.|.|.|||||||:||||:|
Mosquito  1065 AAVIDSIEPLIGAFKLQKISLLRSFCLKTGVQILLQEYAFEQRNRPAFTDADIVNVFPVVKHINP 1129

  Fly  1099 RATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLLGDAQD 1163
            ||:||||||||||.|||||..::||.|||.||||||||:||:|.||..||||||||||::||.|:
Mosquito  1130 RASDAYNFYTTGQTKIQQGYLQDGYGLISEALNLLNNVYGAMHPENAQCLRMLARLSYIMGDPQE 1194

  Fly  1164 ALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEV 1228
            |||||||||:|||||||:|||.||.||.||:||.|||..:..:||||||||||..::|||:||::
Mosquito  1195 ALAIQQRAVLMSERVNGVDHPYTISEYGHLALYCFANSQITTALKLLYRARYLATIVCGENHPDI 1259

  Fly  1229 ALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCMGDFRSALNN 1293
            ||:||||||||||:|||||||||:||||.||::|:|:|.:.||:||||:||||||||||||||.|
Mosquito  1260 ALMDSNISLILHAVGEYELSLRFLEHALALNIRYYGEKSLKVAVSYHLVARTQSCMGDFRSALVN 1324

  Fly  1294 EKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGKLTS-DLPPIHITPPSMG 1357
            |||||:.||.|||||||||::|:||||.||||||:||:|||  |::|||.| .||||||.|||||
Mosquito  1325 EKETYAIYKQQLGENHEKTQESSECLRHLTQQAVVLQKKMN--YANGKLLSTGLPPIHIQPPSMG 1387

  Fly  1358 SVLDMLNTINGILFVKISRKDIVKVRSEIEKHFK-------------TDSTENEVNDAINSIV-- 1407
            |||||||.||||:||:||.|:|...::||||..|             ..:.:.||:..:...:
Mosquito  1388 SVLDMLNAINGIIFVQISSKEIANFKNEIEKRQKEAGAQSQQPGGGPVQANQEEVDQMLMETMQK 1452

  Fly  1408 AAANNNGEAEDAVSKD---IKEQPEAGKQLTNGDKAAATEATSS 1448
            .||....|.:|...||   ::::|              .|.|||
Mosquito  1453 TAAGIPFEEQDGEKKDGAAVEKKP--------------AEVTSS 1482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	163..232	CDD:464466	58/68 (85%)
		GSKIP_dom	<324..387	CDD:398795	50/62 (81%)
		CLU	445..665	CDD:463814	198/219 (90%)
		eIF3_p135	870..1073	CDD:463717	96/229 (42%)
		FxSxx_TPR	<1117..1309	CDD:468560	139/191 (73%)
		TPR repeat	1190..1215	CDD:276809	15/24 (63%)
		TPR repeat	1228..1258	CDD:276809	25/29 (86%)
clu	XP_320668.5	None