DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8435 and YJU2

DIOPT Version :9

Sequence 1:	NP_611092.2	Gene:	CG8435 / 36789	FlyBaseID:	FBgn0034084	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_012828.1	Gene:	YJU2 / 853767	SGDID:	S000001578	Length:	278	Species:	Saccharomyces cerevisiae

Alignment Length:	275	Identity:	94/275 - (34%)
Similarity:	144/275 - (52%)	Gaps:	48/275 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSERKVLNKYYPPDFDPSKIPRM--KLAK-----NRQY-TVRLMAPFNMRCKTCGEYIYKGKKFN 57
            |||||.:|||||||::|.:..::  |:||     |:.: ::|||.||:|||..|.|||.|.:|||
Yeast     1 MSERKAINKYYPPDYNPLEAEKLSRKMAKKLKTMNKSHASIRLMTPFSMRCLECNEYIPKSRKFN 65

  Fly    58 ARKEDVENETYL-GIRIYRFYIKCTRCLQEISFKTDPQNTDYEIEAGATRNFM------------ 109
            .:|| :..|.|| .|:|||..|.|.||...|:|:|||.|:||.:|.|..||::
Yeast    66 GKKE-LLKEKYLDSIKIYRLTISCPRCANSIAFRTDPGNSDYVMEVGGVRNYVPQKPNDDLNAKT 129

  Fly   110 ALKLAEEQARR--EEQELRD-------EEANNPMKLLENRTQQSRNEIETIESLEELR----DLN 161
            |::..:|..:|  .|:|:..       |:|::.|.|||.|..:.:.|.|..|.||.||    :::
Yeast   130 AVESIDETLQRLVREKEMEQNEKMGIKEQADDKMDLLEKRLAKIQQEQEDDEELENLRKKNLEMS 194

  Fly   162 RRQQTVDYNTLLQQYNTVETERERQEREEREDEDFIKSVNFKNKPEGSSRVVAEEIIEEIKDEPL 226
            :|.:.::.:...||...|.|:    :.:...|:.|.......|||..::         :.|..||
Yeast   195 QRAEMINRSKHAQQEKAVTTD----DLDNLVDQVFDNHRQRTNKPGNNN---------DEKRTPL 246

  Fly   227 DTPSAPPPAKQAKPS 241
            ..|::.....|.|.|
Yeast   247 FNPTSTKGKIQKKSS 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8435	NP_611092.2	COG5134	7..>170	CDD:227463	73/196 (37%)
CG8435	NP_611092.2	DUF572	8..>177	CDD:282371	75/202 (37%)
YJU2	NP_012828.1	COG5134	7..278	CDD:227463	89/269 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344330
Domainoid	1	1.000	119	1.000	Domainoid score	I1276
eggNOG	1	0.900	-	-		E1_COG5134
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I1232
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002595
OrthoInspector	1	1.000	-	-		oto100302
orthoMCL	1	0.900	-	-		OOG6_102870
Panther	1	1.100	-	-	LDO	PTHR12111
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2441
SonicParanoid	1	1.000	-	-		X1951
TreeFam	1	0.960	-	-
	13	12.780