DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8435 and yju-2

DIOPT Version :9

Sequence 1:	NP_611092.2	Gene:	CG8435 / 36789	FlyBaseID:	FBgn0034084	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_498576.1	Gene:	yju-2 / 176010	WormBaseID:	WBGene00018149	Length:	323	Species:	Caenorhabditis elegans

Alignment Length:	356	Identity:	143/356 - (40%)
Similarity:	195/356 - (54%)	Gaps:	65/356 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SERKVLNKYYPPDFDPSKIPRMKLAKNRQYTVRLMAPFNMRCKTCGEYIYKGKKFNARKEDVENE 66
            :||||..||||||||||||||.|..||||:..|:|.||||:|.||.||||||||||.::|..|.|
Worm     4 TERKVFQKYYPPDFDPSKIPRAKGQKNRQFVQRVMTPFNMQCNTCHEYIYKGKKFNMKRETAEGE 68

  Fly    67 TYLGIRIYRFYIKCTRCLQEISFKTDPQNTDYEIEAGATRNFMALKLAEEQARR-EEQELRDEEA 130
            ||||::::|||.:|..||.||:||||.:|.||:.|.||||.|.|:||.::|.:: :|||.  |:|
Worm    69 TYLGLKLFRFYFRCPNCLAEITFKTDLENCDYQNEHGATRLFEAVKLYQDQQKQVDEQEA--EDA 131

  Fly   131 NNPMKLLENRTQQSRNEIETIESLEELRDLNRRQQTVDYNTLL----------QQYNTVETERER 185
            .:|||:||.||.|||.|:|.:.:||:|::.:|.::.:|....|          |:...:|.|.:|
Worm   132 KDPMKMLEKRTMQSRQEMEEMGNLEDLQESSRTKECIDTIGFLSSTDPHIAQAQRIKMMEDEDDR 196

  Fly   186 QERE----------ER---EDEDFIKSVNFKNKPEGSSRVVAEEIIEEIKDEPLDTPSA---PPP 234
            ..||          ||   :|||         ..:|:.        |:.||.|  .|||   |..
Worm   197 MARELMGITSEGRIERRIKDDED---------NSDGAD--------EDDKDIP--GPSASVVPST 242

  Fly   235 AKQAKPSTISLSATSSSKASAAQSMVKRKTPLVLVKPKATAVAKPTVATGTTQVESKPAATTPSV 299
            :...||:...|....|..:........|...:.|:|.     |||:        |...::|..|.
Worm   243 SSMLKPAIPKLGMDDSGNSRKRNEQRDRFAGIKLIKK-----AKPS--------EPSTSSTASST 294

  Fly   300 VSAPAETKATNQPAAAPAGLSLLAAYSDSSE 330
            .|||....:    :||.:||||||.|...|:
Worm   295 SSAPPPLPS----SAASSGLSLLADYGSGSD 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8435	NP_611092.2	COG5134	7..>170	CDD:227463	92/163 (56%)
CG8435	NP_611092.2	DUF572	8..>177	CDD:282371	94/179 (53%)
yju-2	NP_498576.1	DUF572	10..220	CDD:282371	104/220 (47%)
yju-2	NP_498576.1	COG5134	11..>148	CDD:227463	85/138 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160718
Domainoid	1	1.000	216	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5134
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6350
Inparanoid	1	1.050	224	1.000	Inparanoid score	I2251
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1583452at2759
OrthoFinder	1	1.000	-	-		FOG0002595
OrthoInspector	1	1.000	-	-		oto20469
orthoMCL	1	0.900	-	-		OOG6_102870
Panther	1	1.100	-	-	LDO	PTHR12111
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2441
SonicParanoid	1	1.000	-	-		X1951
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790