Protein Alignment lbk and NYX

DIOPT Version :10

• Sequence 1: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_072089.2
• Gene: NYX / 60506
• HGNCID: 8082
• Length: 476
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 122/508 - (24%)
• Similarity: 185/508 - (36%)
• Gaps: 132/508 - (25%)

  Fly   250 AAAAAAKASNKYNIDCPKDCKCLNV----LFDCDKLHLERVPV-LPSYVQTLHLANNKLNDTTVL 309
            |..|.|:|       ||..|.|..|    ...||:..|.|||. ||....::.|..|.|
Human    18 AVGACARA-------CPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGL------ 69

  Fly   310 EIRNLLNLTKVSLKRNLLEVIPKFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLH 374
                                  :|:|                  ..:...||.||.|.|..|.|.
Human    70 ----------------------RFLG------------------ERAFGTLPSLRRLSLRHNNLS 94

  Fly   375 TIELNSFPKSNNLVHLILSFN-EITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKL 438
            .|...:|.....|..|.|:.| ::..::..:||.|:.|..|:|:..||.::|.|:...|..|::|
Human    95 FITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALREL 159

  Fly   439 ALNFNQLEINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNL 503
            |...|.........|||.::.:..|:..:|.|                     ::|.|.||   |
Human   160 AAFDNLFRRVPGALRGLANLTHAHLERGRIEA---------------------VASSSLQG---L 200

  Fly   504 TKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQ 568
            .:||.|:|..|.:..:....:.....||.|.|::|.:.|........|.||:||||..|.|
Human   201 RRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNAL---- 261

  Fly   569 ENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEI 633
                                     |:.|.|.|..|.:|..|.|..|::..:...|...|:.|..
Human   262 -------------------------DRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLA 301

  Fly   634 LNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHAVCGYPEHLL 698
            |:|..|.|..:...||:....|.:|......:.|||.|.|.:.|::.  ..:.....|..|..:.
Human   302 LHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEG--SGRVTDVPCASPGSVA 364

  Fly   699 DRHLKSLS---SSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAAS 748
            ...|..::   ||:.:|||         |:::      |:|......||..|:
Human   365 GLDLSQVTFGRSSDGLCVD---------PEEL------NLTTSSPGPSPEPAA 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR	<293..642	CDD:443914	80/349 (23%)
		leucine-rich repeat	293..316	CDD:275380	3/22 (14%)
		leucine-rich repeat	317..338	CDD:275380	2/20 (10%)
		leucine-rich repeat	339..362	CDD:275380	1/22 (5%)
		leucine-rich repeat	363..386	CDD:275380	8/22 (36%)
		leucine-rich repeat	387..410	CDD:275380	7/23 (30%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..457	CDD:275380	7/21 (33%)
		leucine-rich repeat	458..481	CDD:275380	3/22 (14%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		leucine-rich repeat	506..529	CDD:275380	5/22 (23%)
		leucine-rich repeat	530..553	CDD:275380	7/22 (32%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		leucine-rich repeat	578..604	CDD:275380	4/25 (16%)
		leucine-rich repeat	607..630	CDD:275380	6/22 (27%)
		leucine-rich repeat	631..652	CDD:275380	7/20 (35%)
		LRRCT	665..712	CDD:214507	11/49 (22%)
		Ig_3	717..816	CDD:464046	6/32 (19%)
		Ig	835..924	CDD:472250
		Ig strand B	851..855	CDD:409353
		Ig strand C	864..868	CDD:409353
		Ig strand E	890..894	CDD:409353
		Ig strand F	904..909	CDD:409353
		Ig strand G	917..920	CDD:409353
		Ig_3	927..1013	CDD:464046
NYX	NP_072089.2	LRR 1. /evidence=ECO:0000255	60..84		7/69 (10%)
		leucine-rich repeat	63..82	CDD:275380	6/64 (9%)
		LRR	<69..>307	CDD:443914	77/336 (23%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		LRR 2. /evidence=ECO:0000255	85..108		6/22 (27%)
		leucine-rich repeat	107..131	CDD:275380	7/23 (30%)
		LRR 3. /evidence=ECO:0000255	110..133		6/22 (27%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR 4. /evidence=ECO:0000255	134..157		7/22 (32%)
		leucine-rich repeat	156..178	CDD:275380	7/21 (33%)
		LRR 5. /evidence=ECO:0000255	159..181		6/21 (29%)
		leucine-rich repeat	179..202	CDD:275380	8/46 (17%)
		LRR 6. /evidence=ECO:0000255	182..204		8/45 (18%)
		leucine-rich repeat	203..226	CDD:275380	5/22 (23%)
		LRR 7. /evidence=ECO:0000255	205..228		3/22 (14%)
		leucine-rich repeat	227..250	CDD:275380	7/22 (32%)
		LRR 8. /evidence=ECO:0000255	229..252		6/22 (27%)
		leucine-rich repeat	251..274	CDD:275380	12/51 (24%)
		LRR 9. /evidence=ECO:0000255	254..276		10/50 (20%)
		leucine-rich repeat	275..296	CDD:275380	5/20 (25%)
		LRR 10. /evidence=ECO:0000255	277..300		5/22 (23%)
		LRR 11. /evidence=ECO:0000255	302..324		6/21 (29%)
		leucine-rich repeat	323..335	CDD:275378	2/11 (18%)
		LRRCT	331..>365	CDD:214507	8/35 (23%)