Protein Alignment CysRS and CRS1

DIOPT Version :10

• Sequence 1: NP_611087.1
• Gene: CysRS / 36784
• FlyBaseID: FBgn0027091
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_014152.1
• Gene: CRS1 / 855474
• SGDID: S000005191
• Length: 767
• Species: Saccharomyces cerevisiae
• Alignment Length: 782
• Identity: 343/782 - (43%)
• Similarity: 462/782 - (59%)
• Gaps: 93/782 - (11%)

  Fly     6 QPAW-----QAPEAVDRPKLKLFNSLTRQKEDFVPLDGN-NVTWYSCGPTVYDASHMGHARSYIS 64
            ||.|     ||.|.|    |||:|||||.|.:|:|..|| .||||||||||||||||||||:|:|
Yeast    21 QPKWKVPTPQAKETV----LKLYNSLTRSKVEFIPQSGNRGVTWYSCGPTVYDASHMGHARNYVS 81

  Fly    65 FDILRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQ-----------KLPLDEL 118
            .||.|||:.|||||::.:|.|:||||||||.|||||:|||.:..|..           |..|.:.
Yeast    82 IDINRRIIQDYFGYDVQFVQNVTDIDDKIILRARQNYLFDNFVKENDTKFNATVVDKVKTALFQY 146

  Fly   119 L-------GQQKEVLQRFQDTCAKNTDPDKKIMLDKTLQRMN-----------DAVEALTKAVGK 165
            :       |.:.:.::.| :|...|.|.:       ||:..|           :|:|::||  |.
Yeast   147 INKNFTIQGSEIKTIEEF-ETWLSNADTE-------TLKLENPKFPMHVTAVQNAIESITK--GD 201

  Fly   166 GDEREISEKRLLYLNEAKDPISDWLDSLKGAQINDNAVFEALPRYWEDQFHNDMKSLNILPPDVL 230
            ..:.|::      ..:.||.....||...|:.|::..:|..||.|||.:|::||.|||:|||.|.
Yeast   202 SMDAEVA------FEKVKDVTVPLLDKELGSTISNPEIFRQLPAYWEQKFNDDMLSLNVLPPTVT 260

  Fly   231 TRVSEYVPQIVTFIQKIIDNGLAYA-ANNSVYFDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEG 294
            ||||||||:|:.|:|||||||.||| ::.|||||...|||...|.|||..|...|....:.:|||
Yeast   261 TRVSEYVPEIIDFVQKIIDNGYAYATSDGSVYFDTLKFDKSPNHDYAKCQPWNKGQLDLINDGEG 325

  Fly   295 DLSIAEDRLSEKRSANDFALWKASKAGEPWWDSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGV 359
            .||...|  :.|:|.||||||||||||||.|:|||||||||||||||.|||||.|...|||:||:
Yeast   326 SLSNFAD--NGKKSNNDFALWKASKAGEPEWESPWGKGRPGWHIECSVMASDILGSNIDIHSGGI 388

  Fly   360 DLKFPHHDNELAQSEAAFNESEWVKYFLHTGHLTIAGCKMSKSLKNFVTIQEALKKHSATQLRLA 424
            ||.|||||||||||||.|:..:|:.||||||||.|.|.|||||||||:||||||||.|..|||||
Yeast   389 DLAFPHHDNELAQSEARFDNQQWINYFLHTGHLHIEGQKMSKSLKNFITIQEALKKFSPRQLRLA 453

  Fly   425 FLLHSWKDTLDYSENTMEMATQYEKFLNEFFLNVKDLTR------HVLSEEPRRQFDAWTEVEAA 483
            |....|.:.||:.|:.:.....:|..:|.||..::.|..      |:..:        ::.:|..
Yeast   454 FASVQWNNQLDFKESLIHEVKSFENSMNNFFKTIRALKNDAASAGHISKK--------FSPLEKE 510

  Fly   484 LQKKFSNAQVQVHASLCDNIDTRSALDAIRELVSVSNVYIRDNKTRLNSLLLRNVATYITDLLHV 548
            |...|..::.:||::.|||:.|..||..:.|||:.||.||......|....|..:.:|||.:|.:
Yeast   511 LLADFVESESKVHSAFCDNLSTPVALKTLSELVTKSNTYITTAGAALKIEPLIAICSYITKILRI 575

  Fly   549 FGAISGPRGGIGFPVSGGSGAQAAGADLETTVLPYVQSLAEFRYLVREQA-KTLKAFDILKLCDD 612
            .|..|.| ..:|:....||...:.|: ||.||:|||:.|:.||..||..| |..:..:.|:|.|.
Yeast   576 IGFPSRP-DNLGWAAQAGSNDGSLGS-LEDTVMPYVKCLSTFRDDVRSLAIKKAEPKEFLQLTDK 638

  Fly   613 LRDNVLPNLGVRLEDKDIGKYAVKLVDRDSLL------REREAKLAAEAEKAAEKERKKQAAAEA 671
            :|:..|.||.|.|:|::.....:|.:..|..|      .|:.|...|:.:|..|:::.::
Yeast   639 IRNEDLLNLNVALDDRNGQSALIKFLTNDEKLEIVKLNEEKHANELAKKQKKLEQQKLRE----- 698

  Fly   672 AAAKEAQRR----VNPKEMFLAETEKYSAFDENGLPTHDKEGKEVSKGQIKKLQKLQQQQEQRYN 732
              .||.:|:    :.|::|| .:...|||:||.||||.||:|.:::|...|||:|..:||::.:.
Yeast   699 --QKENERKQKAQIKPQDMF-KDVTLYSAWDEQGLPTKDKDGNDITKSMTKKLKKQWEQQKKLHE 760

  Fly   733 EY 734
            ||
Yeast   761 EY 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	343/782 (44%)
CRS1	NP_014152.1	PTZ00399	2..762	CDD:240402	341/780 (44%)