Protein Alignment CysRS and CARS2

DIOPT Version :10

• Sequence 1: NP_611087.1
• Gene: CysRS / 36784
• FlyBaseID: FBgn0027091
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_078813.1
• Gene: CARS2 / 79587
• HGNCID: 25695
• Length: 564
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 214/669 - (31%)
• Similarity: 306/669 - (45%)
• Gaps: 163/669 - (24%)

  Fly     4 RGQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISFDIL 68
            ||: ||..|...: ..::::||||.:||..:.......:||||||||||.:|:|||.||:.|||:
Human    38 RGR-AWLQPTGRE-TGVQVYNSLTGRKEPLIVAHAEAASWYSCGPTVYDHAHLGHACSYVRFDII 100

  Fly    69 RRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLPLDELLGQQKEVLQRFQDTC 133
            ||||:..||.:|..||.|||:|||||:||
Human   101 RRILTKVFGCSIVMVMGITDVDDKIIKRA------------------------------------ 129

  Fly   134 AKNTDPDKKIMLDKTLQRMNDAVEALTKAVGKGDEREISEKRLLYLNEAKDPISDWLDSLKGAQI 198
                                             :|..||...|..|
Human   130 ---------------------------------NEMNISPASLASL------------------- 142

  Fly   199 NDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDNGLAYA-ANNSVYF 262
                        :|:.|..||.:|.:|||.|..||:|.:|||::||:.||..|.||: |..:|||
Human   143 ------------YEEDFKQDMAALKVLPPTVYLRVTENIPQIISFIEGIIARGNAYSTAKGNVYF 195

  Fly   263 DVNGFDKREKHHYAKLVPEAYGDTKSLQEGEGDLSIAEDRLSEKRSANDFALWKASKAGEPWWDS 327
            |:    |.....|.|||....|            .:.|...|:||.|:|||||||:|..|.:|.|
Human   196 DL----KSRGDKYGKLVGVVPG------------PVGEPADSDKRHASDFALWKAAKPQEVFWAS 244

  Fly   328 PWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNESEWVKYFLHTGHL 392
            |||.|||||||||||:||.:||...|||:||:||.||||:||:||.|......:|..||||:|||
Human   245 PWGPGRPGWHIECSAIASMVFGSQLDIHSGGIDLAFPHHENEIAQCEVFHQCEQWGNYFLHSGHL 309

  Fly   393 TIAGC--KMSKSLKNFVTIQEALKKHSATQLRLAFLLHSWKDTLDYSENTMEMATQYEKFLNEFF 455
            ...|.  ||||||||::||::.||..|....|...|..|::..:|||::.|..|.|....|..|
Human   310 HAKGKEEKMSKSLKNYITIKDFLKTFSPDVFRFFCLRSSYRSAIDYSDSAMLQAQQLLLGLGSF- 373

  Fly   456 LNVKDLTRHVLSEEPRRQFDAWTEVEAALQKKFSNAQVQVHASLCDNIDTRSALDAIRELVSVSN 520
              ::|...::     :.|....:..||.|.::.|:.:..|.|:|.|:.||...:|||..|....|
Human   374 --LEDARAYM-----KGQLACGSVREAMLWERLSSTKRAVKAALADDFDTPRVVDAILGLAHHGN 431

  Fly   521 VYIR----DNKTRLNSLLLRNVATYITDLLHVFGAISGPRGGIGFPVSGGSGAQAAGADLETTVL 581
            ..:|    :.:...:..:...:.:|........|            :|..:....:|...|.|:.
Human   432 GQLRASLKEPEGPRSPAVFGAIISYFEQFFETVG------------ISLANQQYVSGDGSEATLH 484

  Fly   582 PYVQSLAEFRYLVREQA-------------KTLKAFDILKLCDDLRDNVLPNLGVRLEDKDIGKY 633
            ..|..|..||..||:.|             :.|:...:|:.||.||..:..: |:.::|:.....
Human   485 GVVDELVRFRQKVRQFALAMPEATGDARRQQLLERQPLLEACDTLRRGLTAH-GINIKDRSSTTS 548

  Fly   634 AVKLVDRDSLLREREAKLA 652
            ..:|:|:    |.::.|.|
Human   549 TWELLDQ----RTKDQKSA 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	214/669 (32%)
CARS2	NP_078813.1	PTZ00399	35..563	CDD:240402	213/667 (32%)
		'HIGH' region	80..90		6/9 (67%)
		'KIIK' region	124..127		2/2 (100%)
		'KMSKS' region	317..321		3/3 (100%)