Protein Alignment CysRS and Cars2

DIOPT Version :10

• Sequence 1: NP_611087.1
• Gene: CysRS / 36784
• FlyBaseID: FBgn0027091
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: XP_011240384.1
• Gene: Cars2 / 71941
• MGIID: 1919191
• Length: 619
• Species: Mus musculus
• Alignment Length: 739
• Identity: 222/739 - (30%)
• Similarity: 317/739 - (42%)
• Gaps: 251/739 - (33%)

  Fly     1 MSKRGQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISF 65
            :.:||: :||.|:..| ..:::.||||.:||..:....:.|:||||||||||.:|:|||.||:.|
Mouse    20 LGRRGR-SWQRPQGQD-TGVQVHNSLTGRKEPLIVARSDAVSWYSCGPTVYDHAHLGHACSYVRF 82

  Fly    66 DILRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLPLDELLGQQKEVLQRFQ 130
            ||:||||:..||.|:...|:|||:|||||:||.:
Mouse    83 DIIRRILTRVFGCNVVMAMSITDVDDKIIKRANE------------------------------- 116

  Fly   131 DTCAKNTDPDKKIMLDKTLQRMNDAVEALTKAVGKGDEREISEKRLLYLNEAKDPISDWLDSLKG 195
                                 ||     :|.|
Mouse   117 ---------------------MN-----VTPA--------------------------------- 122

  Fly   196 AQINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDNGLAYA-ANNS 259
                      :|...:|::|..||.:|.:|||.|..||:|.:|||:.||:.||.:|.||: |..|
Mouse   123 ----------SLASLFEEEFKQDMAALKVLPPTVYLRVTENIPQIIAFIEGIIAHGHAYSTATGS 177

  Fly   260 VYFDVNGFDKREKHHYAKL---VPEAYGDTKSLQEGEGDLSIAEDRLSEKRSANDFALWKASKAG 321
            ||||::.  :.:|  |.||   ||.|      ..|..||        |:||.::|||||||:|..
Mouse   178 VYFDLHA--RGDK--YGKLVNTVPSA------TAEPAGD--------SDKRHSSDFALWKAAKPQ 224

  Fly   322 EPWWDSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNESEWVKYF 386
            |.:|.||||.||||||||||.|||::||...||||||:||.||||:||:||||......:|..||
Mouse   225 EVFWASPWGDGRPGWHIECSTMASEVFGSHLDIHTGGIDLAFPHHENEIAQSEVFHQCQQWGNYF 289

  Fly   387 LHTGHLTIAGC--KMSKSLKNFVTIQEA------------------------------------- 412
            ||:|||.:.|.  ||||||||::||::.
Mouse   290 LHSGHLHVKGTEEKMSKSLKNYITIKDCRLSGRSLLDSCLHCCFDSIAEPSRGPKGKQDLPLRCD 354

  Fly   413 ------------------------------LKKHSATQLRLAFLLHSWKDTLDYSENTMEMATQY 447
                                          ||..|....||..|..:::..::||::|:..|...
Mouse   355 LHGGTTDPVHILHKGLLNRVTQLPFWSKDFLKTFSPDVFRLFCLRTNYRSAIEYSDSTLVEAKHL 419

  Fly   448 EKFLNEFFLNVKDLTRHVLSEEPRRQFDAWTEVEAALQKKFSNAQVQVHASLCDNIDTRSALDAI 512
            ...|..|   |:|...:|     :.|.......|..|.::.::.:..|.|:|.::.||..|::.|
Mouse   420 LLGLASF---VEDARAYV-----KGQLTCGPVEEDVLWERLTSTKKAVKAALANDFDTPRAVNTI 476

  Fly   513 RELVSVSNVYIRDNKTRLNSLLLRNVATYITDLLHVFGAISGPR-----GGI------GFPVSGG 566
            .:||..:|..:|                      .|....||||     |.|      .|...|.
Mouse   477 LDLVHHANRQLR----------------------AVSKEASGPRSPTVFGAIISYVEQFFETVGI 519

  Fly   567 SGA--QAAGADLETTVLP-YVQSLAEFRYLVREQA-------------KTLKAFDILKLCDDLRD 615
            |.|  |....|..|..|. .|..|..||..||:.|             :..:...:|:.||.||.
Mouse   520 SLANRQCVSGDSSTVTLRCVVDELVRFRLKVRQYALDTPGAAGEARKRQLQERQPLLEACDTLRQ 584

  Fly   616 NVLPNLGVRLEDKDIGKYAVKLVD 639
            :::.: |:.::|:.......:|:|
Mouse   585 DLVTH-GINVKDRGSAASTWELLD 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	222/738 (30%)
Cars2	XP_011240384.1	PTZ00399	27..614	CDD:240402	220/731 (30%)