DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CysRS and cars1

DIOPT Version :9

Sequence 1:	NP_611087.1	Gene:	CysRS / 36784	FlyBaseID:	FBgn0027091	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001011365.1	Gene:	cars1 / 496832	XenbaseID:	XB-GENE-5825933	Length:	747	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	435/740 - (58%)
Similarity:	531/740 - (71%)	Gaps:	19/740 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRGQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISFDI 67
            :|.||.|.||....:|.|:|:|||||.||.|||.|||.||||.||||||||||||||||||||||
Frog    11 RRTQPPWSAPNTQAQPGLRLYNSLTRSKELFVPQDGNKVTWYCCGPTVYDASHMGHARSYISFDI 75

  Fly    68 LRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLPLDELLGQQKEVLQRFQDT 132
            |||:|.|||.|::.|.|||||||||||:||||.|||.:| .|....|.| ||......|..|...
Frog    76 LRRVLRDYFKYDVFYCMNITDIDDKIIKRARQRHLFQQY-RERNPRPSD-LLQDVSAALTPFLQR 138

  Fly   133 CAKNTDPDKKIMLDKTLQRMNDAVEALTKAVGKGDEREISEKRLLYLNEAK-DPISDWLDSLKGA 196
            .::..||||:.||::....::.|:..|..||......|..|:....|.||. |.:|||||...||
Frog   139 ISEANDPDKRQMLERIHGSVSAALLPLQDAVSSNARAEELERLSQELMEAAVDLLSDWLDEKHGA 203

  Fly   197 QINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDNGLAYAANNSVY 261
            ||.||::|..||::||.::|.||::||:||||||||||||||:||.|:|:|:|||..|.:|.|||
Frog   204 QITDNSIFSQLPKHWESEYHRDMEALNVLPPDVLTRVSEYVPEIVAFVQRIVDNGYGYVSNGSVY 268

  Fly   262 FDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEGDLSIAEDRLSEKRSANDFALWKASKAGEPWWD 326
            |....|...|||:||||||||.||.|:||||||||||:.||||||:|.||||||||||.|||.|:
Frog   269 FSTAKFHASEKHYYAKLVPEAVGDQKALQEGEGDLSISADRLSEKQSPNDFALWKASKPGEPSWE 333

  Fly   327 SPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNESEWVKYFLHTGH 391
            ||||||||||||||||||..|.|.:.|||.||.||:|||||||||||||.|:...||:|||||||
Frog   334 SPWGKGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFDNDHWVRYFLHTGH 398

  Fly   392 LTIAGCKMSKSLKNFVTIQEALKKHSATQLRLAFLLHSWKDTLDYSENTMEMATQYEKFLNEFFL 456
            |||||||||||||||:||::||:|::|.|||||||:|:||||||||.||||.|.|||||:|||||
Frog   399 LTIAGCKMSKSLKNFITIKDALQKNTARQLRLAFLMHAWKDTLDYSSNTMESAVQYEKFMNEFFL 463

  Fly   457 NVKDLTRHVLSEEPRRQFDAWTEVEAALQKKFSNAQVQVHASLCDNIDTRSALDAIRELVSVSNV 521
            |||||.|  ...:...||..|...|..|...|.:.:..||.:||||||||:.::.:|.|||..|.
Frog   464 NVKDLLR--APTDVTGQFVKWEVPELELNSCFYSKKAAVHEALCDNIDTRTVMEEMRSLVSQCNS 526

  Fly   522 YIRDNKTRL---NSLLLRNVATYITDLLHVFGAISGPRGGIGFPVSGGSGAQAAGADLETTVLPY 583
            ||...|...   |.||||:|::|:|.:|.|||||.|.. .||||:.|...:.    :||:||:||
Frog   527 YIASRKAAKQPPNRLLLRSVSSYLTAMLKVFGAIEGEE-VIGFPIGGSDNSM----NLESTVMPY 586

  Fly   584 VQSLAEFRYLVREQAKTLKAFDILKLCDDLRDNVLPNLGVRLEDKDIGKYAVKLVDRDSLLRERE 648
            :|.|::||..||:.|:..|..::|:|.|.|||:|||.|||||||.:.....||||||::||:|:|
Frog   587 LQVLSQFREGVRQIARQHKVTEVLQLSDLLRDDVLPELGVRLEDHEGLPTVVKLVDRETLLKEKE 651

  Fly   649 AKLAAEAEKAAEKE---RKKQAAAEAAAAKEAQRRVNPKEMFLAETEKYSAFDENGLPTHDKEGK 710
            .|..||.||..:||   ||||   :..|||..:.:|:|.:||..||:|||.|||:|.||||.|||
Frog   652 EKRKAEEEKQRKKEEAARKKQ---QQEAAKLEKMKVSPSQMFQLETDKYSQFDESGFPTHDTEGK 713

  Fly   711 EVSKGQIKKLQKLQQQQEQRYNEYL 735
            |:||||.|||:||.:.||:.:.|||
Frog   714 ELSKGQSKKLRKLYEAQEKLHKEYL 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	435/740 (59%)
CysRS	NP_611087.1	CysRS_core	21..437	CDD:173899	271/416 (65%)
cars1	NP_001011365.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		6/13 (46%)
		PTZ00399	11..738	CDD:240402	433/738 (59%)
		'HIGH' region	56..66		9/9 (100%)
		'KMSKS' region	405..409		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..722		40/73 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	551	1.000	Domainoid score	I247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1328
Inparanoid	1	1.050	838	1.000	Inparanoid score	I441
OMA	1	1.010	-	-		QHG54140
OrthoDB	1	1.010	-	-		D480663at33208
OrthoFinder	1	1.000	-	-		FOG0000992
OrthoInspector	1	1.000	-	-		oto103420
Panther	1	1.100	-	-	LDO	PTHR10890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1431
SonicParanoid	1	1.000	-	-		X4186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110