DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CysRS and cars1

DIOPT Version :9

Sequence 1:	NP_611087.1	Gene:	CysRS / 36784	FlyBaseID:	FBgn0027091	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001112372.1	Gene:	cars1 / 368284	ZFINID:	ZDB-GENE-030328-29	Length:	824	Species:	Danio rerio

Alignment Length:	755	Identity:	443/755 - (58%)
Similarity:	544/755 - (72%)	Gaps:	41/755 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRGQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISFDI 67
            ||.||.|..||..|..||:|:|||||.||.|||..||.|.||.||||||||||||||||||||||
Zfish    90 KRVQPPWSPPEGTDISKLRLYNSLTRTKEVFVPQKGNRVLWYCCGPTVYDASHMGHARSYISFDI 154

  Fly    68 LRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLPLDELLGQQKEVLQ----- 127
            |||||.:||.|::.|.|||||||||||:|||||:|.::|   .:|.|      ...::||
Zfish   155 LRRILKNYFKYDVFYCMNITDIDDKIIKRARQNYLLEQY---REKKP------SAAQILQDVLTA 210

  Fly   128 --RFQDTCAKNTDPDKKIMLDKTLQRMNDAVEA----LTKAV-GKGDEREISEKRLLYLNEAKDP 185
              .|:...|:.||||||.|    |:|::.||:|    |..|| .|..:..|.::..:.|.||||.
Zfish   211 RTPFKAKLAETTDPDKKQM----LERLDSAVDAALGPLQVAVQSKAAQDSIQKQAQVLLEEAKDL 271

  Fly   186 ISDWLDSLKGAQINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDN 250
            :||||||..|:|:.:|::|..||:|||.::|.||::||:||||||||||||||:||.|::||:||
Zfish   272 LSDWLDSQFGSQVTENSIFSLLPKYWEGEYHKDMEALNVLPPDVLTRVSEYVPEIVEFVKKIVDN 336

  Fly   251 GLAYAANNSVYFDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEGDLSIAEDRLSEKRSANDFALW 315
            |..|.:|.|||||...||....|.||||||||.||.|:||||||||||:.||||||||.||||||
Zfish   337 GYGYESNGSVYFDTAKFDSCPAHSYAKLVPEAVGDQKALQEGEGDLSISADRLSEKRSQNDFALW 401

  Fly   316 KASKAGEPWWDSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNES 380
            ||||.|||.||||||.|||||||||||||..|.|.:.|||.||.||:|||||||||||||.|...
Zfish   402 KASKPGEPSWDSPWGMGRPGWHIECSAMAGSILGESMDIHGGGFDLRFPHHDNELAQSEAYFEND 466

  Fly   381 EWVKYFLHTGHLTIAGCKMSKSLKNFVTIQEALKKHSATQLRLAFLLHSWKDTLDYSENTMEMAT 445
            .||:||||||||||||||||||||||:||::||.||:|.|||||||:||||||||||.||||.|.
Zfish   467 YWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALAKHTARQLRLAFLMHSWKDTLDYSNNTMESAI 531

  Fly   446 QYEKFLNEFFLNVKDLTRHVLSEEPRRQFDAWTEVEAALQKKFSNAQVQVHASLCDNIDTRSALD 510
            |||:|:|||||||||:.|.  ..:...|::.|...|..|.|.|.:.:..||.:|||||||||||:
Zfish   532 QYERFINEFFLNVKDILRS--PTDITGQYEKWEAEEIELNKCFYDKKTSVHGALCDNIDTRSALE 594

  Fly   511 AIRELVSVSNVYI---RDNKTRLNSLLLRNVATYITDLLHVFGAISGPRGGIGFPVSGGSGAQAA 572
            .:|.||..||.|:   |..|...|.:||:::|.|:||:|..||||.| ...||||| ||:|   .
Zfish   595 EMRALVGQSNTYMAARRSAKLPPNRMLLQSIALYLTDMLKTFGAIEG-TDPIGFPV-GGNG---Q 654

  Fly   573 GADLETTVLPYVQSLAEFRYLVREQAKTLKAFDILKLCDDLRDNVLPNLGVRLEDKDIGKYAVKL 637
            .||||:||:||:..|::||..||:.|:..|..::|:|||.|||:.||.|||||||:|....:|||
Zfish   655 SADLESTVMPYLSVLSDFREDVRKIAREKKVTELLQLCDQLRDDTLPELGVRLEDRDGLPTSVKL 719

  Fly   638 VDRDSLLREREAKLAAEAEKAAEKE---RKKQAAAEAAAAKEAQRRVNPKEMFLAETEKYSAFDE 699
            ||:::||:|:|.|...:.:|..:||   ||||   |...||.|:.::.|.|||.:||:|||:|||
Zfish   720 VDKETLLKEKEEKKKLKDDKRKKKEEAARKKQ---EQEMAKLAKMKLKPSEMFRSETDKYSSFDE 781

  Fly   700 NGLPTHDKEGKEVSKGQIKKLQKLQQQQEQRYNEYLASIE 739
            .|.||||.||||:|||..|||:||.:.||:.:||||.|.:
Zfish   782 TGFPTHDAEGKELSKGLTKKLRKLYETQEKLHNEYLQSTQ 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	442/751 (59%)
CysRS	NP_611087.1	CysRS_core	21..437	CDD:173899	275/427 (64%)
cars1	NP_001112372.1	GST_C_CysRS_N	2..74	CDD:198343
		PTZ00399	85..822	CDD:240402	443/755 (59%)
		CysRS_core	108..523	CDD:173899	275/427 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580147
Domainoid	1	1.000	552	1.000	Domainoid score	I245
eggNOG	1	0.900	-	-		E1_COG0215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1328
Inparanoid	1	1.050	850	1.000	Inparanoid score	I417
OMA	1	1.010	-	-		QHG54140
OrthoDB	1	1.010	-	-		D480663at33208
OrthoFinder	1	1.000	-	-		FOG0000992
OrthoInspector	1	1.000	-	-		oto41149
orthoMCL	1	0.900	-	-		OOG6_100332
Panther	1	1.100	-	-	LDO	PTHR10890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1431
SonicParanoid	1	1.000	-	-		X4186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800