Protein Alignment CysRS and Cars1

DIOPT Version :10

• Sequence 1: NP_611087.1
• Gene: CysRS / 36784
• FlyBaseID: FBgn0027091
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_038770.3
• Gene: Cars1 / 27267
• MGIID: 1351477
• Length: 831
• Species: Mus musculus
• Alignment Length: 744
• Identity: 441/744 - (59%)
• Similarity: 540/744 - (72%)
• Gaps: 19/744 - (2%)

  Fly     3 KRGQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISFDI 67
            :|.||.|..|...:..:|:|:|||||.|:.|:|.||..||||.||||||||||||||||||||||
Mouse    95 RRVQPQWSPPAGTEPCRLRLYNSLTRNKDVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDI 159

  Fly    68 LRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLPLDELLGQQKEVLQRFQDT 132
            |||:|.|||.|::.|.|||||||||||||||||:||::|  ..||.|..:||...::.::.|...
Mouse   160 LRRVLRDYFQYDVFYCMNITDIDDKIIRRARQNYLFEQY--REQKPPATQLLKDVRDAMKPFSVK 222

  Fly   133 CAKNTDPDKKIMLDKTLQRMNDAVEALTKAVGKG-DEREISEKRLLYLNEAKDPISDWLDSLKGA 196
            .::.|||||:.||::....:..|.|.|.:||... ...|:..|..:.|.||||.:||||||..|:
Mouse   223 LSETTDPDKRQMLERIQNSVKLATEPLEQAVRSSLSGEEVDSKVQVLLEEAKDLLSDWLDSTGGS 287

  Fly   197 QINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDNGLAYAANNSVY 261
            ::.||::|..||::||::||.||::||:||||||||||||||:||.|:|||:|||..||:|.|||
Mouse   288 EVTDNSIFSKLPKFWEEEFHKDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYASNGSVY 352

  Fly   262 FDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEGDLSIAEDRLSEKRSANDFALWKASKAGEPWWD 326
            ||...|...|||.|.||||||.||.|:||||||||||:.||||||||.||||||||||.|||.|.
Mouse   353 FDTAKFAASEKHSYGKLVPEAVGDQKALQEGEGDLSISADRLSEKRSPNDFALWKASKPGEPSWP 417

  Fly   327 SPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNESEWVKYFLHTGH 391
            .|||||||||||||||||..:.|.:.|||.||.||:|||||||||||||.|....||:|||||||
Mouse   418 CPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGH 482

  Fly   392 LTIAGCKMSKSLKNFVTIQEALKKHSATQLRLAFLLHSWKDTLDYSENTMEMATQYEKFLNEFFL 456
            |||||||||||||||:||::|||||||.|||||||:||||||||||.||||.|.|||||:|||||
Mouse   483 LTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFMNEFFL 547

  Fly   457 NVKDLTRHVLSEEPRRQFDAWTEVEAALQKKFSNAQVQVHASLCDNIDTRSALDAIRELVSVSNV 521
            ||||:.|..:  :...||:.|...|..|.|.|...:..||.:||||||||:.::.:|.|||..|:
Mouse   548 NVKDILRAPV--DITGQFEKWEAEEVELNKNFYGKKTAVHEALCDNIDTRTVMEEMRALVSQCNL 610

  Fly   522 YIRDNKT---RLNSLLLRNVATYITDLLHVFGAISGPRGGIGFPVSGGSGAQAAGADLETTVLPY 583
            |:...|.   |.|..||.|:|.|:|.:|.:||||. ....:|||| ||.|   ...:||:||:||
Mouse   611 YMAARKAERRRPNRALLENIAMYLTHMLKIFGAIE-EESPLGFPV-GGPG---TNLNLESTVMPY 670

  Fly   584 VQSLAEFRYLVREQAKTLKAFDILKLCDDLRDNVLPNLGVRLEDKDIGKYAVKLVDRDSLLRERE 648
            :|.|:|||..||:.|:..|..::|:|.|.|||::||.||||.||.:.....|||||||:||:|:|
Mouse   671 LQVLSEFREGVRKIAREKKVLEVLQLSDALRDDILPELGVRFEDHEGLPTVVKLVDRDTLLKEKE 735

  Fly   649 AKLAAEAEKAAEKE---RKKQAAAEAAAAKEAQRRVNPKEMFLAETEKYSAFDENGLPTHDKEGK 710
            .|..||.||..:||   ||||   |..|||.|:.::.|.||||:|..|||.||||||||||.|||
Mouse   736 GKKRAEEEKRRKKEEAARKKQ---EQEAAKLAKMKIPPSEMFLSEVNKYSKFDENGLPTHDTEGK 797

  Fly   711 EVSKGQIKKLQKLQQQQEQRYNEYLASIE 739
            |:||||.|||:||.:.||:.|.|||..::
Mouse   798 ELSKGQAKKLKKLFEAQEKLYKEYLQMLQ 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	441/740 (60%)
Cars1	NP_038770.3	GST_C_CysRS_N	4..76	CDD:198343
		PTZ00399	91..827	CDD:240402	441/744 (59%)
		'HIGH' region	140..150		9/9 (100%)
		'KIIK' region	184..187		2/2 (100%)
		'KMSKS' region	489..493		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..766		16/32 (50%)