Protein Alignment CysRS and cars-1

DIOPT Version :10

• Sequence 1: NP_611087.1
• Gene: CysRS / 36784
• FlyBaseID: FBgn0027091
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001293288.1
• Gene: cars-1 / 171821
• WormBaseID: WBGene00000800
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 747
• Identity: 373/747 - (49%)
• Similarity: 498/747 - (66%)
• Gaps: 19/747 - (2%)

  Fly     3 KRGQPAWQAPE-AVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISFD 66
            ||.|..|..|: |...|:|.::||||||||.|||.:|..|.||.|||||||:|||||||||:|.|
 Worm    11 KRVQKHWDQPKNATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLD 75

  Fly    67 ILRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLPLDELLGQQKEVLQRFQD 131
            ||||:..|||||::.::|||||:|||||:||||:||...|..|:|..|:.::.......|:.|:.
 Worm    76 ILRRVFRDYFGYDVEFIMNITDVDDKIIKRARQSHLLKSYFNESQAPPVMKVCEDVVAALEHFKT 140

  Fly   132 TCAKNTDPDKKIMLDKTLQRMNDAVEALTKAVGKGDEREISEKRLLYLNEAKDPISDWLDSLKGA 196
            ......|||||.|.:..::::.....||.:|:...|.....|.:...|||::|.:|:|||...|.
 Worm   141 KFETEMDPDKKKMFEVMIKKVQQQSSALEEAMKAQDSIATEEAKGRLLNESRDVLSEWLDHNHGK 205

  Fly   197 QINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDNGLAYAA-NNSV 260
            .:.|::||:.|.:.:|.:|..||..||:||.|||||||||||:::|:::|||.||.|||| :.||
 Worm   206 DVRDHSVFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDGSV 270

  Fly   261 YFDVNGFDKREKHHYAKLVPEAYGD-----TKSLQEGEGDLSIAEDRLSEKRSANDFALWKASKA 320
            |||...|::..||.||||||||||:     .|:::|.||:||:::|||..|||.|||||||:||.
 Worm   271 YFDTKAFEQNPKHFYAKLVPEAYGEDSEQLLKNMKESEGELSMSDDRLKSKRSPNDFALWKSSKD 335

  Fly   321 GEPWWDSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNESEWVKY 385
            |||:|.|.||.||||||||||.|:|.|.|...|||.||.||||||||||:||.||.:::..||.|
 Worm   336 GEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNY 400

  Fly   386 FLHTGHLTIAGCKMSKSLKNFVTIQEALKKHSATQLRLAFLLHSWKDTLDYSENTMEMATQYEKF 450
            |||.|.|.|.|.|||||||||:||::||:.::..||||.||:|:|.|.||||.:|||.|.|:||.
 Worm   401 FLHCGTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERALQFEKI 465

  Fly   451 LNEFFLNVKDLTRHVLSEEPRRQFDAWTEVEAALQKKFSNAQVQVHASLCDNIDTRSALDAIREL 515
            .|||||.|||..|.....:....:..:...|..|.::|...:.:||.:|||::||||.::..|||
 Worm   466 TNEFFLLVKDFLRRHYKPDRSEGYQKFQGKELKLMEEFGKLKSEVHEALCDSVDTRSVIEKFREL 530

  Fly   516 VSVSNVYIRDNKTR---LNSLLLRNVATYITDLLHVFGAISGPRGGIGFPVS----GGSGAQAAG 573
            :|:.|.||.:.:..   .|.|||||:|.|||:||.:||||......||| ||    .|.|| :..
 Worm   531 ISLGNAYIVEKEKEGHVPNCLLLRNIAAYITNLLKIFGAIPQSNQEIGF-VSEDECNGEGA-STS 593

  Fly   574 ADLETTVLPYVQSLAEFRYLVREQAKTLKAFDILKLCDDLRDNVLPNLGVRLEDKDIGKYAVKLV 638
            .:.|..|:||:.:||:||..||..||..|...||:.||.|||..|..|||||||:: |:..||||
 Worm   594 FNKEAVVMPYLDALAQFREKVRLIAKEHKVNGILEECDTLRDKTLTELGVRLEDRN-GQTVVKLV 657

  Fly   639 DRDSLLREREAKLAAEAEKAAEKERKKQAAAEAAAAKEAQRRVNPKEMFL--AETEKYSAFDENG 701
            ||.:||||:|.|...:..|..||..|:|.|.|.|..:.|.:::.|:|:|.  ....|||.|||.|
 Worm   658 DRATLLREQEQKDTEKKRKDKEKADKEQKAREKADKEAAAKKIKPEELFKQGEHVGKYSKFDERG 722

  Fly   702 LPTHDKEGKEVSKGQIKKLQKLQQQQEQRYNE 733
            :|||..:|.|::|.|||||:|:.:.|:::|.:
 Worm   723 VPTHLADGTEITKSQIKKLEKVYEAQKKKYQQ 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	373/747 (50%)
cars-1	NP_001293288.1	PTZ00399	16..754	CDD:240402	370/740 (50%)