Protein Alignment Jhe and Aadac

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_075872.1
• Gene: Aadac / 67758
• MGIID: 1915008
• Length: 398
• Species: Mus musculus
• Alignment Length: 404
• Identity: 90/404 - (22%)
• Similarity: 144/404 - (35%)
• Gaps: 165/404 - (40%)

  Fly   112 DCLYLNVYRPEIRKSAL-PVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFL 175
            |.:.:.:|.|:.:..|| ..:.||||||:..|||.       :|  |.:.:....|::|
Mouse    86 DSVPVRIYIPKRKSMALRRGLFYIHGGGWCLGSAA-------HF--SYDTLSRWTAHKL------ 135

  Fly   176 STQDA-VMSGNFGL----------KDQNLALRW-VQRNI-RFFGGDPQRVTIFGQSAGGVAAHMH 227
               || |:|.::||          :|...:||| :|.:: ..:|.||:||.:.|.||||
Mouse   136 ---DAVVVSTDYGLAPKHHFPRQFEDVYRSLRWFLQEDVLEKYGVDPRRVGVSGDSAGG------ 191

  Fly   228 LLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATK 292
                                |:..|:.:|.::.
Mouse   192 --------------------NLAAAVTQQLIQD-------------------------------- 204

  Fly   293 LLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVV 357
                                |.|:..|:|.|.:  :|   ..|.:.|::|     ...||:...|
Mouse   205 --------------------PDVKIKLKVQALI--YP---ALQALDTNVP-----SQQEGSHFPV 239

  Fly   358 NILGNETLRQSFNLRFDELLQELLEFPASFSQDR-REKMMDLLVEVYFQGQHEVNELTVQGFMN- 420
                   |.:|..:||         :...|:.|| .||.|.|...|..:..|.:.      |:|
Mouse   240 -------LTRSLMVRF---------WSEYFTTDRGLEKAMLLNQHVPMESSHLLQ------FVNW 282

  Fly   421 --LISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSAN------------VTGK 471
              |:.:|..|.|:|    ||  .||....| :..|.|.:...:....||            :|.:
Mouse   283 SSLLPERYKKSPVY----KN--PTPGSSEL-AQKYPGFIDVKACPLLANDNILHHLPKTYIITCQ 340

  Fly   472 YGVVHCDDLLYLFR 485
            |.|:..|.|:|:.|
Mouse   341 YDVLRDDGLMYVKR 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	90/404 (22%)
Aadac	NP_075872.1	Abhydrolase_3	106..356	CDD:400284	85/384 (22%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	110..112		1/1 (100%)