DRSC/TRiP Functional Genomics Resources

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Protein Alignment Jhe and NLGN2

DIOPT Version :10

Sequence 1:NP_523758.3 Gene:Jhe / 36780 FlyBaseID:FBgn0010052 Length:579 Species:Drosophila melanogaster
Sequence 2:NP_065846.1 Gene:NLGN2 / 57555 HGNCID:14290 Length:835 Species:Homo sapiens


Alignment Length:582 Identity:164/582 - (28%)
Similarity:261/582 - (44%) Gaps:108/582 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 FMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQKNY-LLPT---PVVYGD-------- 110
            |:|:|||.||:|..||..|:......|:.:|:.....|.|..: .||.   ||.:.|        
Human    69 FLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATY 133

  Fly   111 -----EDCLYLNVYRP--------------------EIR-KSALPVMVYIHGGGFFGGSAG--PG 147
                 |||||||:|.|                    :|| ....|||:::|||.:..|:..  .|
Human   134 VQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDG 198

  Fly   148 VTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRV 212
            .....|    |.||:.|:.||||..|||||.|....||:||.||..||||:..||..|||||:|:
Human   199 SVLAAY----GNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERI 259

  Fly   213 TIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLS 277
            ||||..||....::.:||..|.|||.:.|:.||||...:::..|||:..||||  |.|...|. .
Human   260 TIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLA--AKVGCDRE-D 321

  Fly   278 TVKLTKALRRINATKLLNAGDGLKYWDVD----HMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMP 338
            :.:..:.|||..:.:|::.       ||.    |:. |.|||:..:..|     .|..::.||..
Human   322 SAEAVECLRRKPSRELVDQ-------DVQPARYHIA-FGPVVDGDVVPD-----DPEILMQQGEF 373

  Fly   339 TSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVE 401
            .:..:|:|...|||...|.:...:|  ....:|:......:..|..:|     :.::.:.:.:..
Human   374 LNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYP-----EGKDVLRETIKF 433

  Fly   402 VYFQ-GQHEVNELTVQGFMNLISDRGFKQPLYNT--IHKNVCHTPNPVYLYSFNY----QGPLSY 459
            :|.. ...:..|:..:..:.|.:|..:..|...|  :|.:.   .:|||.|:|.:    :|...:
Human   434 MYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADY---QSPVYFYTFYHHCQAEGRPEW 495

  Fly   460 ASAYTSANVTGKYGVVHCDDLLYLFRSPL-----LFP-DFQRNSTEAKVIHSFVDYFVHFAKFGK 518
            |.|            .|.|:|.|:|..|:     ||| :|.:|......:  .:.|:.:|||.|.
Human   496 ADA------------AHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGD 546

  Fly   519 PRNSESLTPCSIEVLQSRPDGICD--YHEFANAPDAYQ--GFEVHVASEFQTDRVNLWSHIL 576
            |...   .|...:.:.::|:...:  :.:|.:....|.  |.:..|...::.::|..|..::
Human   547 PNQP---VPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELV 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
JheNP_523758.3 alpha/beta hydrolases 38..527 CDD:473884 156/527 (30%)
NLGN2NP_065846.1 COesterase 42..601 CDD:395084 163/576 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..668
Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9 678..698
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 790..835
Blue background indicates that the domain is not in the aligned region.

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