Protein Alignment Jhe and nlgn4xa

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: XP_021330915.1
• Gene: nlgn4xa / 561122
• ZFINID: ZDB-GENE-100309-2
• Length: 844
• Species: Danio rerio
• Alignment Length: 622
• Identity: 173/622 - (27%)
• Similarity: 265/622 - (42%)
• Gaps: 107/622 - (17%)

  Fly    25 ALATVDQLTVCPPSVGCLKG--TNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYD 87
            |:....|..:...:.|.|:|  |.|........|.::||||||||.|:.||..|:......|:.:
Zfish    35 AITWAQQHPIVTTNYGKLRGLKTPLPNEILGPVEQYLGIPYALPPTGERRFQPPEPPMSWPGIRN 99

  Fly    88 ASAPKMDCIQ-------KNYLLP--------TPVVY---GDEDCLYLNVYRP------------- 121
            |:.....|.|       .|.:||        |.|.|   ..|||||||:|.|
Zfish   100 ATQFAPVCPQFLEDRFLLNDMLPVWFTANLDTVVTYVQDQSEDCLYLNIYVPTEDVGANKGDDFT 164

  Fly   122 ----------EIRKSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLS 176
                      .......|||||||||.:..|: |..:.| ......|.||:||:.||||..||||
Zfish   165 NNEGGENKDIHDENGLRPVMVYIHGGSYMEGT-GNMIDG-SILASYGNVIVVTLNYRLGVLGFLS 227

  Fly   177 TQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVI 241
            |.|....||:||.||..||||::.||:.|.|||:||||||..||.....:..||..|..||.:.|
Zfish   228 TGDQAAKGNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCVSLLTLSHYSEDLFQKAI 292

  Fly   242 SMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAG-DGLKYWDV 305
            ..||||...:|:..||.:..|:|||..   ....|.::.|.:.|:..|..:|:... ...||
Zfish   293 IQSGTALSSWAVNYQPAKYTRILAEKV---GCNMLDSIDLVECLQNKNYKELIEQYITQAKY--- 351

  Fly   306 DHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNE--TLRQS 368
             |:. |.||::..:..|     .|..::.||...:..::||...|||...|..|:.:|  .....
Zfish   352 -HIA-FGPVIDGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGEGFKFVDGIVDSEDGVSAND 409

  Fly   369 FNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLY 432
            |:....:.:..|..:|     :.::.:.:.:..:|.....:.| |...:..:.|.:|..:..|..
Zfish   410 FDFAVSDFVDHLYGYP-----EGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAV 469

  Fly   433 NT--IHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPLLFP---- 491
            .|  :|   ....:|.|.|:|.:........:::.:        .|.|::.|:|..|:|.|
Zfish   470 ATADLH---AQYGSPTYFYAFYHHCQSEMKPSWSDS--------AHGDEVPYVFGIPMLGPTDLF 523

  Fly   492 --DFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFA----NAP 550
              :|.:|......:  .:.|:.:|||.|.|...   .|...:.:.::|:   .:.|.|    |..
Zfish   524 NCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQP---VPQDTKFIHTKPN---RFEEVAWSKYNPK 580

  Fly   551 D---AYQGFEVHVASEFQTDRVNLW------SHILNE 578
            |   .:.|.:..|...::..:|..|      .|.:||
Zfish   581 DQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNINE 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	158/543 (29%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:395084	167/600 (28%)