Protein Alignment Jhe and NLGN3

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 166/604 - (27%)
• Similarity: 257/604 - (42%)
• Gaps: 125/604 - (20%)

  Fly    56 EAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQK------NYLLP----------- 103
            :.::|:|||.||||:.||..|:..|...|:.:|:.....|.|.      ..:||
Human    67 DQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVA 131

  Fly   104 TPVVYGDEDCLYLNVYRP-------------------------------------------EIRK 125
            |.:...:|||||||||.|                                           :||.
Human   132 TYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRD 196

  Fly   126 S-ALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLK 189
            | |.|||||||||.:..|: |..:.| ......|.||::|:.||:|..|||||.|....||:||.
Human   197 SGAKPVMVYIHGGSYMEGT-GNMIDG-SILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLL 259

  Fly   190 DQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIA 254
            ||..|||||..||.||||||:|:|:||...|.....:..||..|.|||.|.|..||:|...:|:.
Human   260 DQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVN 324

  Fly   255 EQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVD----HMTNFRPVV 315
            .||::...||   ||......|.||.:...||:.:|.:|:..       |:.    |:. |.||:
Human   325 YQPVKYTSLL---ADKVGCNVLDTVDMVDCLRQKSAKELVEQ-------DIQPARYHVA-FGPVI 378

  Fly   316 EEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQ 378
            :..:..|     .|..::.||...:..::||...|||...|..::..|  .....|:......:.
Human   379 DGDVIPD-----DPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVD 438

  Fly   379 ELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNT--IHKNVC 440
            .|..:|     :.::.:.:.:..:|.......| |...:..:.|.:|..:.:|...|  :|   .
Human   439 NLYGYP-----EGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLH---A 495

  Fly   441 HTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPL-----LFP-DFQRNSTE 499
            ...:|.|.|:|.:........|::.|        .|.|::.|:|..|:     ||| :|.:|...
Human   496 RYGSPTYFYAFYHHCQSLMKPAWSDA--------AHGDEVPYVFGVPMVGPTDLFPCNFSKNDVM 552

  Fly   500 AKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFA----NAPD---AYQGFE 557
            ...:  .:.|:.:|||.|.|...   .|...:.:.::.:   .:.|.|    |..|   .:.|.:
Human   553 LSAV--VMTYWTNFAKTGDPNKP---VPQDTKFIHTKAN---RFEEVAWSKYNPRDQLYLHIGLK 609

  Fly   558 VHVASEFQTDRVNLWSHIL 576
            ..|...::..:|..|.|::
Human   610 PRVRDHYRATKVAFWKHLV 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	156/546 (29%)
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	164/598 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694