Protein Alignment Jhe and Nceh1

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001120996.1
• Gene: Nceh1 / 294930
• RGDID: 1311104
• Length: 408
• Species: Rattus norvegicus
• Alignment Length: 276
• Identity: 64/276 - (23%)
• Similarity: 109/276 - (39%)
• Gaps: 76/276 - (27%)

  Fly   110 DEDCLYLNVY----RPE--IRKSALPVMVYIHGGGFFGGSAGPGVTGPEYF-------MDSGEVI 161
            |.|.:.:.|:    :|:  :|:|    :|||||||:...||     ...|:       .:....:
  Rat    86 DFDGVEVRVFEGPPKPDEPLRRS----VVYIHGGGWALASA-----KISYYDQLCTAMAEELNAV 141

  Fly   162 LVTMAYRLGPFGFLSTQ--DAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAA 224
            :|::.|||.|..:...|  |.:.:..:.|:.:.|....|         ||.||.:.|.||||
  Rat   142 IVSIEYRLVPQVYFPEQIHDVIRATKYFLQPEVLDKYKV---------DPGRVGVSGDSAGG--- 194

  Fly   225 HMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRIN 289
                             :::......|...|....:.:|.|....|..|.:.:|....:::.
  Rat   195 -----------------NLAAALGQQFTYVESLKNKLKLQALIYPVLQALDFNTPSYQQSMN--- 239

  Fly   290 ATKLLNAGDGLKYWDVDHMTNFRPVVE-------EGLEVD--AFLNAHPMDMLAQGMPTSIPL-- 343
             |.:|.....::|| ||:.......||       ..|:|:  |.|.|. :|..:. :|:||..
  Rat   240 -TPILPRHVMVRYW-VDYFKGNYDFVEAMIVNNHTSLDVERAAALRAR-LDWTSL-LPSSIKKNY 300

  Fly   344 --LLGTVPGEGAVRVV 357
              :|.|:   |..|:|
  Rat   301 KPVLQTI---GDARIV 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	64/276 (23%)
Nceh1	NP_001120996.1	Abhydrolase_3	109..381	CDD:400284	58/249 (23%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		1/1 (100%)