Protein Alignment Jhe and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 161/590 - (27%)
• Similarity: 254/590 - (43%)
• Gaps: 105/590 - (17%)

  Fly    56 EAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDC---IQKNYL------------LPTP 105
            |.::|:|||.||.|:.||..|:......|:.:|:.....|   :.:.:|            |.|.
Human    71 EQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTL 135

  Fly   106 VVY---GDEDCLYLNVYRP-----EIRKSA--------------------LPVMVYIHGGGFFGG 142
            :.|   .:|||||||:|.|     .|:::|                    .|||||||||.:..|
Human   136 MTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEG 200

  Fly   143 SAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGG 207
            : |..:.| ......|.||::|:.||||..|||||.|....||:||.||..||||::.|:..|||
Human   201 T-GNMIDG-SILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGG 263

  Fly   208 DPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPD 272
            ||:||||||..||.....:..||..|.|||.:.|..||||...:|:..||.:..|:|   ||...
Human   264 DPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRIL---ADKVG 325

  Fly   273 ARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGM 337
            ...|.|..:.:.|:..|..:|:..    ......:...|.||::..:..|     .|..::.||.
Human   326 CNMLDTTDMVECLKNKNYKELIQQ----TITPATYHIAFGPVIDGDVIPD-----DPQILMEQGE 381

  Fly   338 PTSIPLLLGTVPGEGAVRVVNILGNE--TLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLV 400
            ..:..::||...|||...|..|:.||  .....|:......:..|..:|     :.::.:.:.:.
Human   382 FLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYP-----EGKDTLRETIK 441

  Fly   401 EVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNT--IHKNVCHTPNPVYLYSFNYQGPLSYASA 462
            .:|.....:.| |...:..:.|.:|..:..|...|  :|   ....:|.|.|:|.:........:
Human   442 FMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLH---AQYGSPTYFYAFYHHCQSEMKPS 503

  Fly   463 YTSANVTGKYGVVHCDDLLYLFRSPLLFP------DFQRNSTEAKVIHSFVDYFVHFAKFGKPRN 521
            :..:        .|.|::.|:|..|::.|      :|.:|......:  .:.|:.:|||.|.|..
Human   504 WADS--------AHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQ 558

  Fly   522 SESLTPCSIEVLQSRPDGICDYHEFA----NAPD---AYQGFEVHVASEFQTDRVNLW------S 573
            .   .|...:.:.::|:   .:.|.|    |..|   .:.|.:..|...::..:|..|      .
Human   559 P---VPQDTKFIHTKPN---RFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHL 617

  Fly   574 HILNE 578
            |.|||
Human   618 HNLNE 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	147/524 (28%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	156/576 (27%)