Protein Alignment Jhe and AADAC

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001077.2
• Gene: AADAC / 13
• HGNCID: 17
• Length: 399
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 113/559 - (20%)
• Similarity: 181/559 - (32%)
• Gaps: 234/559 - (41%)

  Fly     4 QRMLQLLLLGQLLA----GPGP-----------FCAALATVDQLTVCPPSVGCLKGTNLQGYQSE 53
            ::.|.||::|.|:|    .|.|           ..|.|.|:..|..
Human     3 RKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLAT------------------- 48

  Fly    54 RFEAFMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQKNYLLPTPVVYGDEDCLYLNV 118
             |...:|:.:.:...            |::|.:|...|..|   :|..: |...:.:   :.:.|
Human    49 -FVELLGLHHFMDSF------------KVVGSFDEVPPTSD---ENVTV-TETKFNN---ILVRV 93

  Fly   119 YRPEIRKSAL-PVMVYIHGGGFFGGSAGPGVTG----PEYFMDSGEVILVTMAYRLGPFGFLSTQ 178
            |.|:.:..|| ..:.||||||:..|||  .::|    ..:..|..:.::|:..|||.|......|
Human    94 YVPKRKSEALRRGLFYIHGGGWCVGSA--ALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQ 156

  Fly   179 DAVMSGNFGLKDQNLALRWVQRN--IRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVI 241
                     .:|...||||..|.  :..:|.:|:|:.|.|.||||
Human   157 ---------FEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGG-------------------- 192

  Fly   242 SMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVD 306
                  |:..|:.:|.|          |.||.:    :||
Human   193 ------NLAAAVTQQLL----------DDPDVK----IKL------------------------- 212

  Fly   307 HMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQSFNL 371
               ..:.::...|:        |:|:.......:...|.                   |.:|..:
Human   213 ---KIQSLIYPALQ--------PLDVDLPSYQENSNFLF-------------------LSKSLMV 247

  Fly   372 RFDELLQELLEFPASFSQDRR-EKMMDLLVEVYFQGQHEVNELTVQGFMN---LISDRGFKQPLY 432
            ||         :...|:.||. ||.|.....|..:..|      :..|:|   |:.:|..|..:|
Human   248 RF---------WSEYFTTDRSLEKAMLSRQHVPVESSH------LFKFVNWSSLLPERFIKGHVY 297

  Fly   433 NTIHKNVCHTPNPVYLYS---FNYQG-------------------PLSYASAYTSANVTGKYGVV 475
            |          ||.|..|   ..|.|                   ||:|.       :|.:|.::
Human   298 N----------NPNYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYV-------ITCQYDLL 345

  Fly   476 HCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFA 514
            ..|.|:|:.|        .|| |..:|.|:.|:...|.|
Human   346 RDDGLMYVTR--------LRN-TGVQVTHNHVEDGFHGA 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	101/510 (20%)
AADAC	NP_001077.2	Abhydrolase_3	107..374	CDD:400284	85/413 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)