Protein Alignment Jhe and Nlgn1

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: XP_038957495.1
• Gene: Nlgn1 / 116647
• RGDID: 621117
• Length: 863
• Species: Rattus norvegicus
• Alignment Length: 694
• Identity: 186/694 - (26%)
• Similarity: 279/694 - (40%)
• Gaps: 186/694 - (26%)

  Fly     7 LQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTN---LQGYQSERFE-------AFMGI 61
            |.|.|||.||.........|..||.|..          ||   ::|.:.|...       .|:|:
  Rat    29 LTLCLLGCLLQTFHVLSQKLDDVDPLVT----------TNFGKIRGIKKELNNEILGPVIQFLGV 83

  Fly    62 PYALPPIGDLRFSNPK----------------VMPKLLGMYDASAPKMDCIQKNYLLPT------ 104
            |||.||.|:.||..|:                |.|:  .:.|...|::       :||.
  Rat    84 PYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQ--NIIDGRLPEV-------MLPVWFTNNL 139

  Fly   105 PVVYG-----DEDCLYLNVYRP------------------------------------------- 121
            .||..     .|||||||:|.|
  Rat   140 DVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGGPLTKTQTDDLGDNDRAEDE 204

  Fly   122 EIRKSA--LPVMVYIHGGGFFGGSAGPGVTGPEY----FMDSGEVILVTMAYRLGPFGFLSTQDA 180
            :||.|.  .|||||||||.:..|      ||..|    ....|.||::|:.||||..|||||.|.
  Rat   205 DIRDSGGPKPVMVYIHGGSYMEG------TGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQ 263

  Fly   181 VMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSH---------GL 236
            ...||:||.|...||||...||.||||||.|:|:||..|||...::..||..|.         ||
  Rat   264 AAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGL 328

  Fly   237 FHRVISMSGTANVPFAIAEQPLEQARLLAE--FADVPDARNLSTVKLTKALRRINATKLLNAGDG 299
            |.|.|:.||||...:|::.||.:.||:||.  ..:|.|     ||:|.:.|::....:|::.
  Rat   329 FQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVSD-----TVELVECLQKKPYKELVDQ--- 385

  Fly   300 LKYWDVD----HMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNIL 360
                ||.    |:. |.||::..:..|     .|..::.||...:..::||...|||...|.||:
  Rat   386 ----DVQPARYHIA-FGPVIDGDVIPD-----DPQILMEQGEFLNYDIMLGVNQGEGLKFVENIV 440

  Fly   361 GNE--TLRQSFNLRFDELLQELLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLI 422
            .::  .....|:......:..|..:|     :.::.:.:.:..:|.......| |...:..:.|.
  Rat   441 DSDDGVSASDFDFAVSNFVDNLYGYP-----EGKDVLRETIKFMYTDWADRHNPETRRKTLLALF 500

  Fly   423 SDRGFKQPLYNT--IHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFR 485
            :|..:..|...|  :|.|.   .:|.|.|:|.:........|:..|        .|.|::.|:..
  Rat   501 TDHQWVAPAVATADLHSNF---GSPTYFYAFYHHCQTDQVPAWADA--------AHGDEVPYVLG 554

  Fly   486 SPL-----LFP-DFQRNSTEAKVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICD-- 542
            .|:     ||| :|.:|......:  .:.|:.:|||.|.|...   .|...:.:.::|:...:
  Rat   555 IPMIGPTELFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQP---VPQDTKFIHTKPNRFEEVA 614

  Fly   543 YHEFANAPDAYQ--GFEVHVASEFQTDRVNLW------SHILNE 578
            :..::.....|.  |.:..|...::.::||||      .|.||:
  Rat   615 WTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLND 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	163/600 (27%)
Nlgn1	XP_038957495.1	COesterase	52..646	CDD:395084	172/657 (26%)