Protein Alignment Jhe and Ces2

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001177298.1
• Gene: Ces2 / 100910144
• RGDID: 6504334
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 169/550 - (30%)
• Similarity: 252/550 - (45%)
• Gaps: 90/550 - (16%)

  Fly    58 FMGIPYALPPIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ------KNYLLPTPVVYG----DED 112
            |:|||:|.||:|.|||:.|:......|:.||::....|:|      :..||...::..    .||
  Rat    60 FLGIPFAKPPVGPLRFAPPEPPEPWSGVRDATSQPAMCLQNLDILDEVGLLDMKMILSSISMSED 124

  Fly   113 CLYLNVYRPEIRK--SALPVMVYIHGGGFFGGSA----GPGVTGPEYFMDSGEVILVTMAYRLGP 171
            |||||||.|...:  |.|||||:||||....|.|    |..:|..|      ::::||:.||||.
  Rat   125 CLYLNVYAPAHAREGSNLPVMVWIHGGALVVGMASMYDGSLLTVNE------DLVVVTIQYRLGV 183

  Fly   172 FGFLSTQDAVMSGNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGL 236
            .||.||.|....||:|..||..||||||:||..|||:|.||||||:||||.:...|::||.|.||
  Rat   184 LGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVISPMSQGL 248

  Fly   237 FHRVISMSGTANVPFAIAEQPLEQARLLAEFADVPDARNLSTVKLT--KALRRINATKLLNAGDG 299
            ||..|..||.|.:|..|:|              ..:..:.:..||:  :|:......:.|.|..|
  Rat   249 FHGAIMESGVALLPDLISE--------------TSETVSTTVAKLSGCEAMDSEALVRCLRAKSG 299

  Fly   300 LKYWDVDHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNET 364
            .:...::.:....|.|.:|    .||..||.::||......:|.::|....|....:..::|...
  Rat   300 AEILVINKVFKMIPAVVDG----EFLPRHPKELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQ 360

  Fly   365 LRQSFNLRFDELLQELLEFPASFSQDRREKMM------DLLVEVYFQGQHEVNELTVQGFMNLIS 423
            :       ..||.:|.|:   :..:|...:||      |||:|.|.....:...|.:| :..::.
  Rat   361 I-------IKELSRENLQ---AVLKDTAAQMMLPPECGDLLMEEYMGNTDDSQTLQIQ-YTEMMG 414

  Fly   424 DRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPL 488
            |..|..|.....|....|.  |||.|.|.: .| ||.......:|...    |.|::.::|.|
  Rat   415 DFLFVIPALQVAHFQRSHA--PVYFYEFQH-AP-SYFKNVRPPHVKAD----HADEVPFVFGS-- 469

  Fly   489 LFPDFQRNSTEAKVIHS--FVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAPD 551
            .|...:.:.||.:.:.|  .:.|:.:||:.|.| |||.|                .|....:..:
  Rat   470 FFSGMKLDFTEEERLLSRRMMKYWANFARQGNP-NSEGL----------------PYWPALDHDE 517

  Fly   552 AYQGFEVHVASE--FQTDRVNLWSHILNEK 579
            .|...:.|.|.:  .:..|:..|:..|.:|
  Rat   518 QYLQLDTHPAVDRALKARRLQFWTKTLPQK 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	161/494 (33%)
Ces2	NP_001177298.1	COesterase	32..540	CDD:395084	166/541 (31%)