Protein Alignment Jhe and nlgn1

DIOPT Version :10

• Sequence 1: NP_523758.3
• Gene: Jhe / 36780
• FlyBaseID: FBgn0010052
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: XP_017213657.1
• Gene: nlgn1 / 100002610
• ZFINID: ZDB-GENE-090918-1
• Length: 867
• Species: Danio rerio
• Alignment Length: 676
• Identity: 178/676 - (26%)
• Similarity: 278/676 - (41%)
• Gaps: 178/676 - (26%)

  Fly    24 AALATVDQLTVCPPSVGCLKGTNLQGYQSERFE-------AFMGIPYALPPIGDLRFSNPK---- 77
            |.||..::|....|.|....| .::|::.|...       .|:|:|||.||.|:.||..|:
Zfish    41 AQLAASEKLDETDPIVTTTYG-KVRGFKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPIS 104

  Fly    78 ------------VMPKLLGMYDASAPKMDCIQKNYLLPT------PVVYG-----DEDCLYLNVY 119
                        |.|:.|  .:...|       :.:||.      .||..     .||||:||:|
Zfish   105 WSEIRNATQFAPVCPQTL--LEGRLP-------DVMLPVWFTNSIEVVSSYVQDQSEDCLFLNIY 160

  Fly   120 RP-------------------------------------------EIRKSA--LPVMVYIHGGGF 139
            .|                                           :||:|.  .||||::|||.:
Zfish   161 VPTEDVKRISKECARKPGKKICRKGGPLSKKQNDDLADNDGAEDEDIRESGSPKPVMVFVHGGSY 225

  Fly   140 FGGSAGPGVTGPEY----FMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQR 200
            ..|      ||..:    ....|.||::|:.||||..|||||.|....||:||.|...||||...
Zfish   226 MEG------TGNMFDGSILASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSE 284

  Fly   201 NIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSH---------GLFHRVISMSGTANVPFAIAEQ 256
            ||.||||||.|:|:||..||....::..||..|.         |||.|.|:.||||...:|::.|
Zfish   285 NIAFFGGDPLRITVFGSGAGASCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQ 349

  Fly   257 PLEQARLLAEFADVPDARNL-STVKLTKALRRINATKLLNAGDGLKYWDVD----HMTNFRPVVE 316
            |.:.||:||:....    || .||::.:.|::.:..:|:..       |:.    |:. |.||::
Zfish   350 PAKYARMLAKKVGC----NLKDTVEMVECLQKKHYKELVEQ-------DIQPARYHIA-FGPVID 402

  Fly   317 EGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQS--FNLRFDELLQE 379
            ..:..|     .|..::.||...:..::||...|||...|..|:.||...|:  |:......:.:
Zfish   403 GDVIPD-----DPQILMEQGEFLNYDIMLGVNQGEGLKFVELIVDNENGVQANDFDYAVSSFVDD 462

  Fly   380 LLEFPASFSQDRREKMMDLLVEVYFQGQHEVN-ELTVQGFMNLISDRGFKQPLYNT--IHKNVCH 441
            |..:|     :.::.:.:.:..:|.......| |...:..:.|.:|..:..|...|  :|.:.
Zfish   463 LYGYP-----EGKDILRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSSF-- 520

  Fly   442 TPNPVYLYSFNYQGPLSYASAYTSANVTGKYGVVHCDDLLYLFRSPL-----LFP-DFQRNSTEA 500
             .:|.|.|:|.:.........:..|        .|.|::.|:|..|:     ||| :|.:|....
Zfish   521 -GSPTYFYAFYHHCQTEQVPPWADA--------AHGDEIPYVFGLPMIGPTELFPCNFSKNDVML 576

  Fly   501 KVIHSFVDYFVHFAKFGKPRNSESLTPCSIEVLQSRPDGICDYHEFA----NAPD---AYQGFEV 558
            ..:  .:.|:.:|||.|.|...   .|...:.:.::|:   .:.|.|    |..|   .:.|.:.
Zfish   577 SAV--VMTYWTNFAKTGDPNQP---VPQDTKFIHTKPN---RFEEVAWTRYNQKDQLYLHIGLKP 633

  Fly   559 HVASEFQTDRVNLW------SHILNE 578
            .|...::.::||||      .|.|||
Zfish   634 RVKEHYRANKVNLWLELVPHLHSLNE 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Jhe	NP_523758.3	alpha/beta hydrolases	38..527	CDD:473884	157/596 (26%)
nlgn1	XP_017213657.1	COesterase	53..647	CDD:395084	168/650 (26%)