Protein Alignment CG8388 and ZNF462

DIOPT Version :10

• Sequence 1: NP_611075.1
• Gene: CG8388 / 36763
• FlyBaseID: FBgn0034062
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_006717272.1
• Gene: ZNF462 / 58499
• HGNCID: 21684
• Length: 2567
• Species: Homo sapiens
• Alignment Length: 729
• Identity: 129/729 - (17%)
• Similarity: 223/729 - (30%)
• Gaps: 269/729 - (36%)

  Fly    58 SDAEWDQFMAHMRRNLPVTFRITGSKAQAQLLLKLIKEDFFEEYFRAVKELRKEEPDALVEPPRC 122
            ||.|.|.              ||.::......:..||||..|    ..|..||||.:...:|.:.
Human   249 SDTEEDD--------------ITDNQKHKPPKVPKIKEDDIE----MKKRKRKEEGEKEKKPRKK 295

  Fly   123 LEWYPREM---AWQLELSRKDIRRSEPLFKLHNFLISETSSGYISRQEAVSMIPPLVLGVEPHHK 184
            :   |:::   |.....|.|..:|.:....|...:..........::|:...: |:.|.....:|
Human   296 V---PKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKV-PVTLSTPSLNK 356

  Fly   185 VLDMCAAPGSKTAQLIESLHAGDGGTIPSGFVMANDVDNNRCYMLVHQAKRLNSPCFVVTNGDSS 249
              ..|||             |..|..:|...:.:.|.|               .|.||.|| :..
Human   357 --PPCAA-------------AALGNDVPDLNLSSGDPD---------------LPIFVSTN-EHE 390

  Fly   250 TFPSMQYTKDDGTVSPLKFDRVLCDVPCSGDGTLRKNADIWNKWNLAQASNLHG----------- 303
            .|...:...:  .:....|||:|   ..:.||:           .|:::...:|
Human   391 LFQEAENALE--MLDDFDFDRLL---DAASDGS-----------PLSESGGENGTTTQPTYTSQV 439

  Fly   304 ---------------LQYRI--LKRGAELLEVGGKLVYSTCSLNPIENEAVLHHLLKESDDSLEI 351
                           |:.||  |:..|:|.:..|:..:.|..:|.|        ||   |..|::
Human   440 MPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNI--------LL---DIELQL 493

  Fly   352 VECSGALPTLKYSTGLTYWEPASKDLTFYKSFEEV-----------PESQRTVLRPGMFPPPKEE 405
            .|....:.:..|| .|..:.|.:|: |..|..:::           |..:..:....:.|    |
Human   494 QELGPVIRSGVYS-HLEAFVPCNKE-TLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMP----E 552

  Fly   406 AVNRYHLD-------RCLRILPHQQNTGGFFVALLEK------------------KKPLPWE--- 442
            .:.:|..|       :|.::...::.         ||                  :|...|:
Human   553 QLFKYQEDCQARSQAKCAKLQTDEER---------EKNGSEEDDDEKPGKRVIGPRKKFHWDDTI 608

  Fly   443 ------TVTAVVGADGQESSETAIVEPPQKKTKYMRGFKEDPF------------VFFDEKEEVF 489
                  .|...:|....|.:::      |....|::.|.|...            :.|.|...|
Human   609 RTLLCNLVEIKLGCYELEPNKS------QSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSV- 666

  Fly   490 DSLNKFFQLSADFEPRNLLTRCKVGKKKNVYFCSSIVRDIVQLNEKRIKMI---NLGVKSFVRCA 551
                           .|.||.....||            ::...:.::|.:   .|.:.||   .
Human   667 ---------------HNHLTSAPAKKK------------VIPAPKPKVKEVMVKTLPLHSF---P 701

  Fly   552 TRNIEC----DFRLASEGLANVN--------AYIGSQRRVMVQKQDLIAL-------LSCTDPT- 596
            |...||    |.:..:..:|:|:        |.|.:........|:.|.|       ||...|:
Human   702 TMLKECSPKKDQKTPTSLVASVSGPPTSSSTAAIAAASSSSAPAQETICLDDSLDEDLSFHSPSL 766

  Fly   597 ---------------RPPEISSLTAETQKNLQGVASGSCVLECMVEDVKLATVGWKGAMSLRAYV 646
                           .||..|.::..|.|...|           :.:.|||::..|..::....:
Human   767 DLVSEALAVINNGNKGPPVGSRISMPTTKPRPG-----------LREEKLASIMSKLPLATPKKL 820

  Fly   647 DQYDTVHMLRLLGG 660
            |...|.|...|:.|
Human   821 DSTQTTHSSSLIAG 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	3..78	CDD:462262	4/19 (21%)
		C2H2 Zn finger	264..281	CDD:275368	4/16 (25%)
		C2H2 Zn finger	289..309	CDD:275368	5/47 (11%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..369	CDD:275368	4/18 (22%)
		C2H2 Zn finger	440..461	CDD:275368	4/29 (14%)
		C2H2 Zn finger	469..489	CDD:275368	5/31 (16%)
		C2H2 Zn finger	497..515	CDD:275368	3/17 (18%)
ZNF462	XP_006717272.1	C2H2 Zn finger	2054..2074	CDD:275368
		zf-H2C2_5	2086..2110	CDD:404746
		C2H2 Zn finger	2088..2108	CDD:275368
		C2H2 Zn finger	2117..2138	CDD:275368
		C2H2 Zn finger	2146..2167	CDD:275368
		C2H2 Zn finger	2317..2337	CDD:275368
		C2H2 Zn finger	2363..2383	CDD:275368
		C2H2 Zn finger	2391..2412	CDD:275368
		C2H2 Zn finger	2477..2497	CDD:275368