DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8299 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_611066.1	Gene:	CG8299 / 36751	FlyBaseID:	FBgn0034052	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	255	Identity:	87/255 - (34%)
Similarity:	132/255 - (51%)	Gaps:	43/255 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ISTHIVGGDQADIADFPYQVSVRLETYMLLHICGGSIYAPRVVITAAHCIKGRYASYIRIVAGQN 88
            :|:.||||..:...::|:|.|:::..   .|||||::.|.|.|||||||.:            ::
Mouse   573 LSSRIVGGTVSSEGEWPWQASLQIRG---RHICGGALIADRWVITAAHCFQ------------ED 622

  Fly    89 SIADLE-----------------EQGVKVSKLIPHAGYNKKTYVNDIGLIITREPLEYSALVQPI 136
            |:|..:                 |...|||:|..|..:.:.::..|:.|:....|:.|||.|:|:
Mouse   623 SMASPKLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPV 687

  Fly   137 AVALEAP--PSGAQAVVSGWGKRAEDDEALPAMLRAVELQIIEKSTCGAQYLTKDYTVTDEMLCA 199
            .:...:.  ..|....::|||.:.|.. .:...|:.|::|::.:..|...|   .|.|:..||||
Mouse   688 CLPARSHFFEPGQHCWITGWGAQREGG-PVSNTLQKVDVQLVPQDLCSEAY---RYQVSPRMLCA 748

  Fly   200 GYLEGGKDTCNGDSGGPLAV---DG--VLVGVVSWGVGCGREGFPGVYTSVNSHIDWIEE 254
            ||.:|.||.|.|||||||..   .|  .|.|:||||:||||..|.||||.|...|:||::
Mouse   749 GYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVINWIQQ 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8299	NP_611066.1	Tryp_SPc	27..252	CDD:214473	84/248 (34%)
CG8299	NP_611066.1	Tryp_SPc	28..255	CDD:238113	86/251 (34%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	84/248 (34%)
		Tryp_SPc	577..809	CDD:238113	86/251 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910