Protein Alignment Cdk5 and CDK11B

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: XP_011540792.1
• Gene: CDK11B / 984
• HGNCID: 1729
• Length: 804
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 124/304 - (40%)
• Similarity: 192/304 - (63%)
• Gaps: 27/304 - (8%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            ::::..:.:|.|||||.|::.:::.|.|||||||::::::.||.|.::||||..:.:.:|.|||.
Human   444 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVT 508

  Fly    66 LIDVLHSDK--KLTLVFEHCDQDLKKYFDS-----LNGEIDMAVCRSFMLQLLRGLAFCHSHNVL 123
            :.:::....  |:.:|..:.:.|||...::     |.||:     ::.|:|||||:...|.:.:|
Human   509 VREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEV-----KTLMIQLLRGVKHLHDNWIL 568

  Fly   124 HRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSA 188
            |||||..|||::..|.||:.||||||.:|.|:|.|:..|||||||.|::|.|||.|:|::||||.
Human   569 HRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSV 633

  Fly   189 GCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAIT----SWS 249
            |||..||. ..:|||||...:||:.|:|:.||||:|..|||      |..||:...:|    .::
Human   634 GCIFGELL-TQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG------YSELPAVKKMTFSEHPYN 691

  Fly   250 QLVPR----LNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDS 289
            .|..|    |:.:|.||:.|.|...|.:|||||..::|.||.::
Human   692 NLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRET 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	122/297 (41%)
CDK11B	XP_011540792.1	STKc_CDC2L1	441..732	CDD:173741	122/299 (41%)