Protein Alignment Cdk5 and CDK13

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: XP_016868239.1
• Gene: CDK13 / 8621
• HGNCID: 1733
• Length: 1542
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 125/341 - (36%)
• Similarity: 184/341 - (53%)
• Gaps: 57/341 - (16%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            :.|:|.:..|||||||.|:|.|::||.|:||||:||||.:.||.|.:|:|||.:|::|.|::|:.
Human   702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIIN 766

  Fly    66 LIDVLHSDKK-----------LTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHS 119
            :.::: :||:           ..||||:.|.||....:|.....:....:|||.||:.||.:||.
Human   767 MKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHK 830

  Fly   120 HNVLHRDLKPQNLLINKNGELKLADFGLAR-------------------------------AFGI 153
            .|.||||:|..|:|:|..|::|||||||||                               :||.
Human   831 KNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESAWLMLIWEKVIFIWRILLMQMSAGSFGD 895

  Fly   154 PVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRV 218
            ..:.|:.:|:|||||||::|.|.:.||.:||:||.||||.||. ..:|:|..:..|.||..|.|:
Human   896 SSRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELF-TKKPIFQANQELAQLELISRI 959

  Fly   219 LGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSK-------GRDLLQKLLICRPNQRIS 276
            .|:|....||      |.:.||.|..:....|...:|..:       ..||...:|...|::|.:
Human   960 CGSPCPAVWP------DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCT 1018

  Fly   277 AEAAMQHPYFTDSSSS 292
            ||.|:|..:..|...|
Human  1019 AEQALQCEFLRDVEPS 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	123/331 (37%)
CDK13	XP_016868239.1	STKc_CDK12	697..1028	CDD:270847	123/333 (37%)