Protein Alignment Cdk5 and CKA1

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_012229.1
• Gene: CKA1 / 854776
• SGDID: S000001297
• Length: 372
• Species: Saccharomyces cerevisiae
• Alignment Length: 336
• Identity: 96/336 - (28%)
• Similarity: 165/336 - (49%)
• Gaps: 65/336 - (19%)

  Fly     4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALK--------------RVRLDEDDEGVPSSAL----- 49
            |:...|:|.|.|..||:|...|:...:.:|              ::..|..:|.||.:.|
Yeast    40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKD 104

  Fly    50 -----REICLLKELK----------HKNIVRLIDVLHS--DKKLTLVFEHCDQ-DLKKYFDSLNG 96
                 ::..:||.::          |.||:.|.|::..  .|...||||:.|. |.:..:..|.
Yeast   105 QYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLT- 168

  Fly    97 EIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLI-NKNGELKLADFGLARAFGIPVKCYSA 160
              |:.: |.:|.:||:.|.:|||..::|||:||.|::| :||.:|:|.|:|||..:.:.:: |:.
Yeast   169 --DLEI-RFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNV 229

  Fly   161 EVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPN-- 223
            .|.:.:::.|::|...::|..|:|:||.|.:||.:.....|.|.|:...|||:||.:||||.:
Yeast   230 RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFE 294

  Fly   224 ------EDSWPGVSH-LSDYVALPSFPAITSWSQLVPRLNS--KGR----DLLQKLLICRPNQRI 275
                  |.:.|...: :..|:..|       |.:.:...|.  .|.    ||:..||.....:|:
Yeast   295 KYLLKYEITLPREFYDMDQYIRKP-------WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL 352

  Fly   276 SAEAAMQHPYF 286
            :|:.||.||:|
Yeast   353 TAKEAMGHPWF 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	95/334 (28%)
CKA1	NP_012229.1	STKc_CK2_alpha	21..363	CDD:271034	95/334 (28%)