Protein Alignment Cdk5 and KIN28

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_010175.1
• Gene: KIN28 / 851450
• SGDID: S000002266
• Length: 306
• Species: Saccharomyces cerevisiae
• Alignment Length: 298
• Identity: 115/298 - (38%)
• Similarity: 169/298 - (56%)
• Gaps: 11/298 - (3%)

  Fly     3 KYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLI 67
            :|.|.:|:|||||..|:.|....|...:|:|.::..|..:|:..||:||:..|:|::|.|::.||
Yeast     6 EYTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELI 70

  Fly    68 DVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNL 132
            |:..:...|.||.|....||:......:.....|..:::||..|||:..||.:.:|||||||.||
Yeast    71 DIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNL 135

  Fly   133 LINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELAD 197
            |.:.:|::|:||||||||...|.:..::.|||.|||.|::|||||.||::||:||.|.|.|||.
Yeast   136 LFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELM- 199

  Fly   198 AGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRL---NSKG 259
            ...|..||.:.:||:...||.||||.:..||.||....|..|..:|. .|..:|..|.   :...
Yeast   200 LRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPP-PSRDELRKRFIAASEYA 263

  Fly   260 RDLLQKLLICRPNQRISAEAAMQHPYF------TDSSS 291
            .|.:..:|...|.:|.:|...::..||      :|.||
Yeast   264 LDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSS 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	110/285 (39%)
KIN28	NP_010175.1	STKc_CDK7	7..302	CDD:270833	115/297 (39%)