Protein Alignment Cdk5 and CDK11A

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_001300825.1
• Gene: CDK11A / 728642
• HGNCID: 1730
• Length: 783
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 123/304 - (40%)
• Similarity: 191/304 - (62%)
• Gaps: 27/304 - (8%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            ::::..:.:|.|||||.|::.:::.|.|||||||::::::.||.|.::||||..:.:.:|.|||.
Human   423 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVT 487

  Fly    66 LIDVLHSDK--KLTLVFEHCDQDLKKYFDS-----LNGEIDMAVCRSFMLQLLRGLAFCHSHNVL 123
            :.:::....  |:.:|..:.:.|||...::     |.||:     ::.|:|||||:...|.:.:|
Human   488 VREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEV-----KTLMIQLLRGVKHLHDNWIL 547

  Fly   124 HRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSA 188
            |||||..|||::..|.||:.||||||.:|.|:|.|:..|||.|||.|::|.|||.|:|::||||.
Human   548 HRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSV 612

  Fly   189 GCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAIT----SWS 249
            |||..||. ..:|||||:..:||:.|:|:.||||:|..|||      |..||....:|    .::
Human   613 GCIFGELL-TQKPLFPGNSEIDQINKVFKELGTPSEKIWPG------YSELPVVKKMTFSEHPYN 670

  Fly   250 QLVPR----LNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDS 289
            .|..|    |:.:|.||:.|.|...|.:|||||..::|.||.::
Human   671 NLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRET 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	121/297 (41%)
CDK11A	NP_001300825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..396
		STKc_CDC2L1	420..711	CDD:173741	121/299 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..783