Protein Alignment Cdk5 and CDKL5

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_003150.1
• Gene: CDKL5 / 6792
• HGNCID: 11411
• Length: 1030
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 115/297 - (38%)
• Similarity: 172/297 - (57%)
• Gaps: 20/297 - (6%)

  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65
            |.|::.:..:|||.||.|.|.|:::|.||||:|:.:..|::|.|..:.|||:.:|:.||.:|||.
Human    10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVE 74

  Fly    66 LIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQ 130
            |.:......||.||||:.::::.:..:.:...:.....:|::.||::.:.:||.::::|||:||:
Human    75 LKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPE 139

  Fly   131 NLLINKNGELKLADFGLARAFGIPVKC-YSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAE 194
            ||||:.|..|||.|||.||........ |:..|.|.|||.|::|.||. |..|:||||.||||.|
Human   140 NLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP-YGKSVDMWSVGCILGE 203

  Fly   195 LADAGRPLFPGSDVLDQLMKIFRVLG-TPNEDSWPGVSHLSDYVALP-----SFPAITSWSQLVP 253
            |:| |:|||||...:|||..|.:||| .|:|       .:..:.:.|     .|||:.....|..
Human   204 LSD-GQPLFPGESEIDQLFTIQKVLGPLPSE-------QMKLFYSNPRFHGLRFPAVNHPQSLER 260

  Fly   254 R----LNSKGRDLLQKLLICRPNQRISAEAAMQHPYF 286
            |    |||...||::.||...|..|...|..:.||.|
Human   261 RYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	113/293 (39%)
CDKL5	NP_003150.1	STKc_CDKL5	11..297	CDD:270838	113/294 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..566
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..834