Protein Alignment Cdk5 and CDK15

DIOPT Version :10

• Sequence 1: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_001353315.1
• Gene: CDK15 / 65061
• HGNCID: 14434
• Length: 435
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 151/294 - (51%)
• Similarity: 197/294 - (67%)
• Gaps: 18/294 - (6%)

  Fly     4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLID 68
            |..:||:|||:|.||:||.:|...::||||.:.::. :||||.:|:||..|||.|||.|||.|.|
Human   103 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNA-EEGVPFTAIREASLLKGLKHANIVLLHD 166

  Fly    69 VLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLL 133
            ::|:.:.||.|||:...||.:|.....|.:.....|.||.|||||||:.|..:||||||||||||
Human   167 IIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLL 231

  Fly   134 INKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADA 198
            |:..|||||||||||||..||.:.||:|||||||||||.|.||..|::.:|:|.||||..|:..
Human   232 ISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQ- 295

  Fly   199 GRPLFPG-SDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPS-FPAITS------WSQL--VP 253
            |:||||| |::|:||.||:.|||.|.||:|||||.|.:|  .|. ||..|.      |::|  ||
Human   296 GQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNY--NPEWFPLPTPRSLHVVWNRLGRVP 358

  Fly   254 RLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFT 287
                :..||..::|...|..|:||:.|:.|.||:
Human   359 ----EAEDLASQMLKGFPRDRVSAQEALVHDYFS 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	149/291 (51%)
CDK15	NP_001353315.1	STKc_PFTAIRE2	102..387	CDD:270852	149/291 (51%)